Alex Sonneborn
YOU?
Author Swipe
View article: Combining the alpha-2 adrenergic agonist clonidine with naloxone rescues fentanyl-induced physiologic dysfunction and increases survival
Combining the alpha-2 adrenergic agonist clonidine with naloxone rescues fentanyl-induced physiologic dysfunction and increases survival Open
Fentanyl leads to tens of thousands of overdose deaths every year despite widespread availability of naloxone. Like other opioids, fentanyl causes respiratory depression. Unlike morphine, high dose fentanyl rapidly produces airway obstruct…
View article: Divergent Subregional Information Processing in Mouse Prefrontal Cortex During Working Memory
Divergent Subregional Information Processing in Mouse Prefrontal Cortex During Working Memory Open
Working memory (WM) is a critical cognitive function allowing recent information to be temporarily held in mind to inform future action. This process depends on coordination between key subregions in prefrontal cortex (PFC) and other conne…
View article: The classic psychedelic DOI induces a persistent desynchronized state in medial prefrontal cortex
The classic psychedelic DOI induces a persistent desynchronized state in medial prefrontal cortex Open
Administration or consumption of classic psychedelics (CPs) leads to profound changes in experience which are often described as highly novel and meaningful. They have shown substantial promise in treating depressive symptoms and may be th…
View article: Serotonin-2C and -2a receptor co-expression on cells in the rat medial prefrontal cortex
Serotonin-2C and -2a receptor co-expression on cells in the rat medial prefrontal cortex Open
Neural function within the medial prefrontal cortex (mPFC) regulates normal cognition, attention and impulse control, implicating neuroregulatory abnormalities within this region in mental dysfunction related to schizophrenia, depression a…
View article: Sleeping Sickness Disrupts the Sleep-Regulating Adenosine System
Sleeping Sickness Disrupts the Sleep-Regulating Adenosine System Open
Patients with sleeping sickness, caused by the parasite Trypanosoma brucei , have disruptions in both sleep timing and sleep architecture. However, the underlying cause of these sleep disturbances is not well understood. Here, we assessed …
View article: The norepinephrine transporter regulates dopamine-dependent synaptic plasticity in the mouse dorsal hippocampus
The norepinephrine transporter regulates dopamine-dependent synaptic plasticity in the mouse dorsal hippocampus Open
The rodent dorsal hippocampus is essential for episodic memory consolidation, a process dependent on dopamine D1-like receptor activation. It was previously thought that the ventral tegmental area provided the only supply of dopamine to do…
View article: An Adenosine-Mediated Glial-Neuronal Circuit for Homeostatic Sleep
An Adenosine-Mediated Glial-Neuronal Circuit for Homeostatic Sleep Open
Sleep homeostasis reflects a centrally mediated drive for sleep, which increases during waking and resolves during subsequent sleep. Here we demonstrate that mice deficient for glial adenosine kinase (AdK), the primary metabolizing enzyme …