Alex Steimle
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View article: A prebiotic-postbiotic combination supports dietary carbohydrate-targeting functional properties in a fiber-deprived microbiota
A prebiotic-postbiotic combination supports dietary carbohydrate-targeting functional properties in a fiber-deprived microbiota Open
Dietary fiber deprivation compromises gut mucosal barrier integrity by promoting microbial degradation of host mucus, a process linked to various gut-related auto immune diseases. While postbiotics are considered safer alternatives to fibe…
View article: Gut microbial factors predict disease severity in a mouse model of multiple sclerosis
Gut microbial factors predict disease severity in a mouse model of multiple sclerosis Open
Gut bacteria are linked to neurodegenerative diseases but the risk factors beyond microbiota composition are limited. Here we used a pre-clinical model of multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE), to identif…
View article: Gut microbiome-based prediction of autoimmune neuroinflammation
Gut microbiome-based prediction of autoimmune neuroinflammation Open
Gut commensals are linked to neurodegenerative diseases, yet little is known about causal and functional roles of microbial risk factors in the gut–brain axis. Here, we employed a pre-clinical model of multiple sclerosis in mice harboring …
View article: The gut commensal Bacteroides vulgatus mpk reduces Candida albicans pathogenicity towards epithelial cells
The gut commensal Bacteroides vulgatus mpk reduces Candida albicans pathogenicity towards epithelial cells Open
The human body is colonized by various microbes, among them the yeast Candida albicans . Mostly harmless, this opportunist causes also disease, ranging from superficial infections to sepsis. Risk factors are disturbed host defenses, mucosa…
View article: Concentrated Raw Fibers Enhance the Fiber-Degrading Capacity of a Synthetic Human Gut Microbiome
Concentrated Raw Fibers Enhance the Fiber-Degrading Capacity of a Synthetic Human Gut Microbiome Open
Consumption of prebiotic fibers to modulate the human gut microbiome is a promising strategy to positively impact health. Nevertheless, given the compositional complexity of the microbiome and its inter-individual variances, generalized re…
View article: Deprivation of dietary fiber in specific-pathogen-free mice promotes susceptibility to the intestinal mucosal pathogen <i>Citrobacter rodentium</i>
Deprivation of dietary fiber in specific-pathogen-free mice promotes susceptibility to the intestinal mucosal pathogen <i>Citrobacter rodentium</i> Open
The change of dietary habits in Western societies, including reduced consumption of fiber, is linked to alterations in gut microbial ecology. Nevertheless, mechanistic connections between diet-induced microbiota changes that affect coloniz…
View article: Dietary modulation alters susceptibility to <i>Listeria monocytogenes</i> and <i>Salmonella typhimurium</i> in a gut microbiota-independent manner
Dietary modulation alters susceptibility to <i>Listeria monocytogenes</i> and <i>Salmonella typhimurium</i> in a gut microbiota-independent manner Open
Food safety has considerably improved worldwide, yet infections with food-borne human enteric pathogens, such as Listeria spp. and Salmonella spp., still cause numerous hospitalizations and fatalities. Thus, the need to shed more light on …
View article: Constructing a gnotobiotic mouse model with a synthetic human gut microbiome to study host–microbe cross talk
Constructing a gnotobiotic mouse model with a synthetic human gut microbiome to study host–microbe cross talk Open
View article: Quantitative assay to detect bacterial glycan-degrading enzyme activities in mouse and human fecal samples
Quantitative assay to detect bacterial glycan-degrading enzyme activities in mouse and human fecal samples Open
View article: Gut Commensal-Induced IκBζ Expression in Dendritic Cells Influences the Th17 Response
Gut Commensal-Induced IκBζ Expression in Dendritic Cells Influences the Th17 Response Open
Intestinal commensal bacteria can have a large impact on the state of health and disease of the host. Regulation of Th17 cell development by gut commensals is known to contribute to their dichotomous role in promoting gut homeostasis and h…
View article: Weak Agonistic LPS Restores Intestinal Immune Homeostasis
Weak Agonistic LPS Restores Intestinal Immune Homeostasis Open
View article: An important question: Which LPS do you use?
An important question: Which LPS do you use? Open
During the last decade the invertebrate Galleria mellonella has successfully been used as a powerful and reliable model host for the analysis of bacterial pathogenesis as it offers an inexpensive a...
View article: Outer membrane vesicles blebbing contributes to<i>B. vulgatus</i>mpk-mediated immune response silencing
Outer membrane vesicles blebbing contributes to<i>B. vulgatus</i>mpk-mediated immune response silencing Open
The Gram negative intestinal symbiont Bacteroides vulgatus mpk is able to prevent from induction of colonic inflammation in Rag1-/- mice and promotes immune balance in Il2-/- mice. These inflammation-silencing effects…
View article: How intestinal commensals affect the immune system and the outcome of inflammatory disorders: novel molecular insights
How intestinal commensals affect the immune system and the outcome of inflammatory disorders: novel molecular insights Open
The gut is considered to be the biggest immunological organ in mammals and the composition of the intestinal microbiota is therefore assumed to have widespread effects on the immune system of its host. During past years, more and more insi…
View article: Extensive Mobilome-Driven Genome Diversification in Mouse Gut-Associated<i>Bacteroides vulgatus</i>mpk
Extensive Mobilome-Driven Genome Diversification in Mouse Gut-Associated<i>Bacteroides vulgatus</i>mpk Open
Like many other Bacteroides species, Bacteroides vulgatus strain mpk, a mouse fecal isolate which was shown to promote intestinal homeostasis, utilizes a variety of mobile elements for genome evolution. Based on sequences collected by Paci…
View article: Structure and function: Lipid A modifications in commensals and pathogens
Structure and function: Lipid A modifications in commensals and pathogens Open
Lipopolysaccharides (LPS) of Gram negative bacteria are one of the most potent stimulators of the host innate immune system and LPS recognition is essential for the host organism to clear infections of invading bacterial pathogens. Here we…