Alex Tsui
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View article: In a prospective population-based study, the degree of mobility impairment during hospitalisation is associated with higher degrees of frailty
In a prospective population-based study, the degree of mobility impairment during hospitalisation is associated with higher degrees of frailty Open
Background Hospitals pose a high risk for frailty to develop or accelerate. Still, few community-based cohort studies follow patients before, during, and after hospitalisation. We investigated the degree of immobility during hospitalisatio…
View article: In a prospective population-based study, the degree of mobility impairment during hospitalisation is associated with higher degrees of frailty
In a prospective population-based study, the degree of mobility impairment during hospitalisation is associated with higher degrees of frailty Open
Background Hospitals pose a high risk for frailty to develop or accelerate. Still, few community-based cohort studies follow patients before, during, and after hospitalisation. We investigated the degree of immobility during hospitalisatio…
View article: Clinical Clusters During Acute Illness in Older Frailer Patients with Long-Term Mortality Predictive and Inferential Fidelity
Clinical Clusters During Acute Illness in Older Frailer Patients with Long-Term Mortality Predictive and Inferential Fidelity Open
View article: Persistent delirium is associated with cerebrospinal fluid markers of neuronal injury
Persistent delirium is associated with cerebrospinal fluid markers of neuronal injury Open
Delirium is associated with the risk of future long-term cognitive impairment, but the degree to which markers of neuronal injury may be distinct or shared with dementia has yet to be comprehensively described. We investigated CSF biomarke…
View article: Extremes of baseline cognitive function determine the severity and outcomes of delirium: findings from a prospective longitudinal cohort study
Extremes of baseline cognitive function determine the severity and outcomes of delirium: findings from a prospective longitudinal cohort study Open
Background Epidemiological studies have shown the bidirectional relationship between dementia and delirium to be complex and non‐linear. This has implications for mechanistic studies investigating the extent to which any pathophysiology mi…
View article: Delirium, neurofilament light chain, and progressive cognitive impairment: analysis of a prospective Norwegian population-based cohort
Delirium, neurofilament light chain, and progressive cognitive impairment: analysis of a prospective Norwegian population-based cohort Open
View article: Extremes of baseline cognitive function determine the severity of delirium: a population study
Extremes of baseline cognitive function determine the severity of delirium: a population study Open
Although delirium is a significant clinical and public health problem, little is understood about how specific vulnerabilities underlie the severity of its presentation. Our objective was to quantify the relationship between baseline cogni…
View article: Predicting mortality in acutely hospitalised older patients: the impact of model dimensionality
Predicting mortality in acutely hospitalised older patients: the impact of model dimensionality Open
Background The prediction of long-term mortality following acute illness can be unreliable for older patients, inhibiting the delivery of targeted clinical interventions. The difficulty plausibly arises from the complex, multifactorial nat…
View article: Persistent delirium in older hospital patients: an updated systematic review and meta-analysis
Persistent delirium in older hospital patients: an updated systematic review and meta-analysis Open
Introduction Delirium is associated with future dementia progression. Yet whether this occurs subclinically over months and years, or persistent delirium merges into worsened dementia is not understood. Our objective was to estimate the pr…
View article: Life-space, frailty, and health-related quality of life
Life-space, frailty, and health-related quality of life Open
Introduction Life-space and frailty are closely linked to health-related quality of life and understanding their inter-relationship could indicate potential intervention targets for improving quality of life. We set out to examine the rela…
View article: The relative impact of socioeconomic position and frailty varies by population setting
The relative impact of socioeconomic position and frailty varies by population setting Open
Introduction Frailty and socioeconomic position (SEP) are well‐established determinants of health. However, we know less about the contributions of frailty and SEP in older adults, especially in acute settings. We set out to answer how fra…
View article: Persistent delirium in older hospital patients: an updated systematic review and meta-analysis
Persistent delirium in older hospital patients: an updated systematic review and meta-analysis Open
Introduction Persistent delirium is recognised as a substantial problem, but there are few insights into which patient groups might be particularly affected. Delirium is associated with future dementia progression. Yet whether this occurs …
View article: Do specific delirium aetiologies have different associations with death? A longitudinal cohort of hospitalised patients
Do specific delirium aetiologies have different associations with death? A longitudinal cohort of hospitalised patients Open
View article: Life-Space, Frailty And Health-Related Quality of Life
Life-Space, Frailty And Health-Related Quality of Life Open
View article: Longitudinal associations between diurnal cortisol variation and later-life cognitive impairment
Longitudinal associations between diurnal cortisol variation and later-life cognitive impairment Open
Loss of diurnal HPAA variation is evident in individuals subsequently experiencing more cognitive impairment. It may serve as an early preclinical marker of cognitive decline.
View article: The Scottish Intercollegiate Guidelines Network: risk reduction and management of delirium
The Scottish Intercollegiate Guidelines Network: risk reduction and management of delirium Open
Clinical and research interest in delirium has been rising over the last 15 years. The Scottish Intercollegiate Guidelines Network (SIGN) publication on delirium is a state-of-the-art synthesis of the field, and the first UK guideline sinc…
View article: Systemic inflammation and causal risk for Alzheimer's dementia: Possibilities and limitations of a Mendelian randomization approach
Systemic inflammation and causal risk for Alzheimer's dementia: Possibilities and limitations of a Mendelian randomization approach Open
Epidemiological studies have implicated systemic inflammation in the development of Alzheimer's disease ( AD ). However, these observations have been subject to residual confounding and reverse causation. We applied Mendelian randomization…
View article: Systemic inflammation and modifiable risk factors for cognitive impairment in older persons: Findings from a British birth cohort
Systemic inflammation and modifiable risk factors for cognitive impairment in older persons: Findings from a British birth cohort Open
Serum pro‐inflammatory markers may contribute to dementia pathophysiology and cognitive impairment. In a population‐representative birth cohort, serum C‐reactive protein (CRP), interleukin‐6 (IL‐6), and white cell count (WCC) were measured…
View article: Feasibility of predictive model by clinical and laboratory parameters for risk stratification of geriatric abdominal pain
Feasibility of predictive model by clinical and laboratory parameters for risk stratification of geriatric abdominal pain Open
Background: Assessment of geriatric patients presented with abdominal pain had been challenge for emergency physicians with the ageing population. A rapid, reproducible risk stratification model for the assessment of the need for admission…
View article: Vascular risk factors for male and female urgency urinary incontinence at age 68 years from a British birth cohort study
Vascular risk factors for male and female urgency urinary incontinence at age 68 years from a British birth cohort study Open
Objective To investigate the prevalence of urgency urinary incontinence ( UUI ) at age 68 years and the contribution of vascular risk factors to male and female UUI pathogenesis in addition to the associations with raised body mass index (…
View article: Vascular risk factors for male and female urgency urinary incontinence at age 68 from a British birth cohort study
Vascular risk factors for male and female urgency urinary incontinence at age 68 from a British birth cohort study Open
Objective To investigate the prevalence of UUI at age 68 and the contribution of vascular risk factors to male and female UUI pathogenesis in addition to the associations with raised BMI Subjects and methods 1762 participants were from the…
View article: Delirium symptoms are associated with decline in cognitive function between ages 53 and 69 years: Findings from a British birth cohort study
Delirium symptoms are associated with decline in cognitive function between ages 53 and 69 years: Findings from a British birth cohort study Open
Introduction Few population studies have investigated whether longitudinal decline after delirium in mid‐to‐late life might affect specific cognitive domains. Methods Participants from a birth cohort completing assessments of search speed,…