Explanipedia

Late gestation maternal overnutrition alters gene expression and histomorphology in neonatal foal testes Open

Andrej Trauner, Sarah McCoski, M. Carey Satterfield, Amanda N Bradbery · 2025

Reproductive health of male offspring following perturbations in maternal nutrition is not well-described in the horse; therefore, the objective of this study was to determine the effects of maternal overnutrition on neonatal foal testicul…

Author Correction: A novel antibiotic class targeting the lipopolysaccharide transporter Open

Claudia Zampaloni, Patrizio Mattei, Konrad Bleicher, Lotte Winther, Claudia Thäte , et al. · 2024

Translational PK/PD for the Development of Novel Antibiotics—A Drug Developer’s Perspective Open

Caterina Bissantz, Claudia Zampaloni, Pascale David‐Pierson, Guennaëlle Dieppois, Andreas Guenther , et al. · 2024

Antibiotic development traditionally involved large Phase 3 programs, preceded by Phase 2 studies. Recognizing the high unmet medical need for new antibiotics and, in some cases, challenges to conducting large clinical trials, regulators c…

A novel antibiotic class targeting the lipopolysaccharide transporter Open

Claudia Zampaloni, Patrizio Mattei, Konrad Bleicher, Lotte Winther, Claudia Thäte , et al. · 2024

The relative transmission fitness of multidrug-resistant Mycobacterium tuberculosis in a drug resistance hotspot Open

Chloé Loiseau, Etthel M. Windels, Sebastian M. Gygli, Levan Jugheli, Nino Maghradze , et al. · 2023

Targeting virulence regulation to disarm Acinetobacter baumannii pathogenesis Open

Vincent Trebosc, Valentina Lucchini, Mohit Narwal, Basil Wicki, Sarah Gartenmann , et al. · 2022

The development of anti-virulence drug therapy against Acinetobacter baumannii infections would provide an alternative to traditional antibacterial therapy that are increasingly failing. Here, we demonstrate that the OmpR transcript…

Expression Dysregulation as a Mediator of Fitness Costs in Antibiotic Resistance Open

Andrej Trauner, Amir Banaei‐Esfahani, Sebastian M. Gygli, Philipp Warmer, Julia Feldmann , et al. · 2021

Antimicrobial resistance (AMR) poses a threat to global health and the economy. Rifampicin-resistant Mycobacterium tuberculosis accounts for a third of the global AMR burden.

Expression dysregulation as a mediator of fitness costs in antibiotic resistance Open

Andrej Trauner, Amir Banaei‐Esfahani, Sebastian M. Gygli, Philipp Warmer, Julia Feldmann , et al. · 2021

Antimicrobial resistance (AMR) poses a threat to global health and the economy. Rifampicin-resistant Mycobacterium tuberculosis accounts for a third of the global AMR burden. Gaining the upper hand on AMR requires a deeper underst…

Expression dysregulation as a mediator of fitness costs in antibiotic resistance Open

Andrej Trauner, Amir Banaei‐Esfahani, Sebastian M. Gygli, Philipp Warmer, Julia Feldmann , et al. · 2021

Antimicrobial resistance (AMR) poses a threat to global health and the economy. Rifampicin-resistant Mycobacterium tuberculosis accounts for a third of the global AMR burden. Gaining the upper hand on AMR requires a deeper underst…

Publisher Correction: Prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis Open

Sebastian M. Gygli, Chloé Loiseau, Levan Jugheli, Natia Adamia, Andrej Trauner , et al. · 2021

Prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis Open

Sebastian M. Gygli, Chloé Loiseau, Levan Jugheli, Natia Adamia, Andrej Trauner , et al. · 2021

Model-based integration of genomics and metabolomics reveals SNP functionality in Mycobacterium tuberculosis Open

Ove Øyås, Sònia Borrell, Andrej Trauner, Michael Zimmermann, Julia Feldmann , et al. · 2020

Significance Because genetic diversity in the Mycobacterium tuberculosis complex (MTBC) is less pronounced than in other pathogens, the variable outcome of infection has been attributed mainly to host and environmental factors. Here, we re…

The Genetic Background Modulates the Evolution of Fluoroquinolone-Resistance in Mycobacterium tuberculosis Open

Rhastin A D Castro, Amanda Ross, Lujeko Kamwela, Miriam Reinhard, Chloé Loiseau , et al. · 2019

Fluoroquinolones (FQ) form the backbone in experimental treatment regimens against drug-susceptible tuberculosis. However, little is known on whether the genetic variation present in natural populations of Mycobacterium tuberculosis (Mtb) …

The Evolution of Fluoroquinolone-Resistance inMycobacterium tuberculosisis Modulated by the Genetic Background Open

Rhastin A D Castro, Amanda Ross, Lujeko Kamwela, Miriam Reinhard, Chloé Loiseau , et al. · 2019

Fluoroquinolones (FQ) form the backbone in experimental treatment regimens against drug-susceptible tuberculosis. However, little is known on whether the genetic variation present in natural populations of Mycobacterium tuberculosis ( Mtb …

Transition bias influences the evolution of antibiotic resistance in Mycobacterium tuberculosis Open

Joshua L. Payne, Fabrizio Menardo, Andrej Trauner, Sònia Borrell, Sebastian M. Gygli , et al. · 2019

Transition bias, an overabundance of transitions relative to transversions, has been widely reported among studies of the rates and spectra of spontaneous mutations. However, demonstrating the role of transition bias in adaptive evolution …

Reference set of Mycobacterium tuberculosis clinical strains: A tool for research and product development Open

Sònia Borrell, Andrej Trauner, Daniela Brites, Leen Rigouts, Chloé Loiseau , et al. · 2019

The Mycobacterium tuberculosis complex (MTBC) causes tuberculosis (TB) in humans and various other mammals. The human-adapted members of the MTBC comprise seven phylogenetic lineages that differ in their geographical distribution. There is…

Model-based integration of genomics and metabolomics reveals SNP functionality in Mycobacterium tuberculosis Open

Ove Øyås, Sònia Borrell, Andrej Trauner, Michael Zimmermann, Julia Feldmann , et al. · 2019

Human tuberculosis is caused by members of the Mycobacterium tuberculosis complex (MTBC) and presents variable disease outcomes. The variation has primarily been attributed to host and environmental factors, but recent evidence indicates a…

Resource misallocation as a mediator of fitness costs in antibiotic resistance Open

Andrej Trauner, Amir Banaei‐Esfahani, Sebastian M. Gygli, Philipp Warmer, Julia Feldmann , et al. · 2018

Summary Antimicrobial resistance poses a threat to global health and the economy. It is widely accepted that, in the absence of antibiotics, drug resistance mutations carry a fitness cost. In the case of rifampicin resistance in fast-growi…

Transition bias influences the evolution of antibiotic resistance in Mycobacterium tuberculosis Open

Joshua L. Payne, Fabrizio Menardo, Andrej Trauner, Sònia Borrell, Sebastian M. Gygli , et al. · 2018

Transition bias, an overabundance of transitions relative to transversions, has been widely reported among studies of mutations spreading under relaxed selection. However, demonstrating the role of transition bias in adaptive evolution rem…

Reference Set ofMycobacterium tuberculosisClinical Strains: A tool for research and product development Open

Sònia Borrell, Andrej Trauner, Daniela Brites, Leen Rigouts, Chloé Loiseau , et al. · 2018

The Mycobacterium tuberculosis complex (MTBC) causes tuberculosis (TB) in humans and various other mammals. The human-adapted members of the MTBC comprise seven phylogenetic lineages that differ in their geographical distribution. There is…

Treemmer: a tool to reduce large phylogenetic datasets with minimal loss of diversity Open

Fabrizio Menardo, Chloé Loiseau, Daniela Brites, Mireia Coscollá, Sebastian M. Gygli , et al. · 2018

High-throughput metabolomic analysis predicts mode of action of uncharacterized antimicrobial compounds Open

Mattia Zampieri, Balázs Szappanos, María V. Buchieri, Andrej Trauner, Ilaria Piazza , et al. · 2018

The mode of action of new antimicrobial compounds can be predicted from changes in metabolome profiles in Mycobacterium .

Treemmer: a tool to reduce large phylogenetic datasets with minimal loss of diversity Open

Fabrizio Menardo, Chloé Loiseau, Daniela Brites, Mireia Coscollá, Sebastian M. Gygli , et al. · 2018

Large sequence datasets are difficult to visualize and handle. Additionally, they are often not an adequate representation of the natural diversity, but the result of uncoordinated and convenience sampling. Consequently, they can suffer fr…

Additional file 3: of Treemmer: a tool to reduce large phylogenetic datasets with minimal loss of diversity Open

Fabrizio Menardo, ChloĂŠ Loiseau, Daniela Brites, Mireia Coscollá, Sebastian M. Gygli , et al. · 2018

Table S2. Number of leaves per lineage in the complete and reduced MTB tree showed in Fig. 3 (TXT 174 bytes)

Additional file 1: of Treemmer: a tool to reduce large phylogenetic datasets with minimal loss of diversity Open

Fabrizio Menardo, ChloĂŠ Loiseau, Daniela Brites, Mireia Coscollá, Sebastian M. Gygli , et al. · 2018

Table S3. Results of the root-to-tip regression analysis performed with TempEst onto the influenza tree at different levels of reduction. (TXT 269 bytes)

Additional file 2: of Treemmer: a tool to reduce large phylogenetic datasets with minimal loss of diversity Open

Fabrizio Menardo, ChloĂŠ Loiseau, Daniela Brites, Mireia Coscollá, Sebastian M. Gygli , et al. · 2018

Table S1. Accession numbers used for the MTB tree. (TXT 341 kb)

The within-host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy Open

Andrej Trauner, Qingyun Liu, Laura E. Via, Xin Liu, Xianglin Ruan , et al. · 2017

Antimicrobial resistance in Mycobacterium tuberculosis: mechanistic and evolutionary perspectives Open

Sebastian M. Gygli, Sònia Borrell, Andrej Trauner, Sébastien Gagneux · 2017

Antibiotic-resistant Mycobacterium tuberculosis strains are threatening progress in containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically resistant to many antibiotics, limiting the number of compounds av…

The Within-Host Population Dynamics Of Mycobacterium Tuberculosis Vary With Treatment Efficacy. Open

Andrej Trauner, Qingyun Liu, Laura E. Via, Xin Liu, Xianglin Ruan , et al. · 2017

Data used for the publication of a paper entitled: The within-host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy. The data were derived from: 1. the deep sequencing of serial sputu…

Additional file 2: of The within-host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy Open

Andrej Trauner, Qingyun Liu, Laura E. Via, Xin Liu, Xianglin Ruan , et al. · 2017

Patient-level data on bacterial populations, including the heterogeneity of the population and the burden of infection. (CSV 1 kb)

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