Alexa Beiser
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View article: Genetic Variation of Aquaporin‐4 Associates with Cognition, Brain Volume, and Dementia Risk in a Large Community Cohort
Genetic Variation of Aquaporin‐4 Associates with Cognition, Brain Volume, and Dementia Risk in a Large Community Cohort Open
Background The aquaporin‐4 (AQP4) water channel plays an integral role in removing waste from the brain, including β‐amyloid and tau proteins. Currently, little is known about whether genetic differences in the AQP4 gene are involved in th…
View article: Higher Burden of Cerebral Small Vessel Disease Is Associated With Risk of Incident Stroke in Community‐Dwelling Individuals
Higher Burden of Cerebral Small Vessel Disease Is Associated With Risk of Incident Stroke in Community‐Dwelling Individuals Open
Background Mild manifestations of individual cerebral small vessel disease (CSVD) markers are common and may not denote increased risk, but high CSVD burden identifies individuals at increased risk of stroke and dementia. Scores incorporat…
View article: Hearing Loss, Brain Structure, Cognition, and Dementia Risk in the Framingham Heart Study
Hearing Loss, Brain Structure, Cognition, and Dementia Risk in the Framingham Heart Study Open
Importance Age-related hearing loss is a potentially modifiable risk factor for cognitive impairment and dementia. Objective To investigate the association of hearing loss with brain structure changes, cognitive function, and incident deme…
View article: Association of Platelet Aggregation With Markers of Alzheimer Disease Pathology in Middle-Aged Participants of the Framingham Heart Study
Association of Platelet Aggregation With Markers of Alzheimer Disease Pathology in Middle-Aged Participants of the Framingham Heart Study Open
Our findings indicate that platelet aggregation is linked to PET and MRI markers of AD pathology as early as midlife. These findings support further investigation of platelet-mediated mechanisms in AD pathogenesis.
View article: Multimarker Cerebral Small Vessel Disease Score and Risk of Incident Dementia in the Framingham Heart Study
Multimarker Cerebral Small Vessel Disease Score and Risk of Incident Dementia in the Framingham Heart Study Open
We found a significant association between all-cause dementia and multimarker CSVD scores, which was independent of the FSRP as well as its individual components. Our results support the use of a multimarker CSVD score as an indicator for …
View article: Signature White Matter Hyperintensity Locations Associated With Vascular Risk Factors Derived From 15 653 Individuals
Signature White Matter Hyperintensity Locations Associated With Vascular Risk Factors Derived From 15 653 Individuals Open
BACKGROUND: White matter hyperintensities (WMHs) of presumed vascular origin are common in the elderly and are associated with vascular risk factors. There is evidence that vascular risk factors, in particular hypertension, are associated …
View article: Prevalent Cardiovascular Disease and Atrial Fibrillation in Relation to Cerebral Small Vessel Disease Burden
Prevalent Cardiovascular Disease and Atrial Fibrillation in Relation to Cerebral Small Vessel Disease Burden Open
Background/Objectives: Cardiovascular disease (CVD) contributes to stroke and dementia. Individuals with CVD have high risk for adverse cognitive outcomes and stroke, possibly due to shared risk factors between CVD, stroke, and dementia, w…
View article: Long‐Term Incidence of Dementia Following Transient Ischemic Attack: A Longitudinal Cohort Study
Long‐Term Incidence of Dementia Following Transient Ischemic Attack: A Longitudinal Cohort Study Open
Background The association between transient ischemic attack (TIA) and dementia is incompletely characterized. Determining the cognitive sequalae of TIA is important as it can function as an early warning sign or additional risk factor for…
View article: Midlife Steroid‐Binding Globulin Levels and <i>In Vivo</i> Neuroimaging Measures of Tau in Older Men and Women
Midlife Steroid‐Binding Globulin Levels and <i>In Vivo</i> Neuroimaging Measures of Tau in Older Men and Women Open
Objective In men and women, sex steroid hormones have been associated with increased risk of Alzheimer's disease (AD) dementia. We aimed to investigate the influence of midlife testosterone and sex hormone binding globulin (SHBG) levels on…
View article: Whole genome sequence association analysis of brain structural volume measures in the NHLBI TOPMed Program highlights novel loci in diverse participants
Whole genome sequence association analysis of brain structural volume measures in the NHLBI TOPMed Program highlights novel loci in diverse participants Open
Brain structural volumes are highly heritable and are linked to multiple neuropsychological outcomes, including Alzheimer’s disease (AD). Genome-wide association studies have successfully identified genetic variants associated with intracr…
View article: Multi-population Genome-Wide Association Study Identifies Multiple Novel Loci associated with Asymptomatic Intracranial Large Artery Stenosis
Multi-population Genome-Wide Association Study Identifies Multiple Novel Loci associated with Asymptomatic Intracranial Large Artery Stenosis Open
Background Intracranial large artery stenosis (ILAS) is one of the most common causes of stroke worldwide and is associated with the risk for future vascular events. Asymptomatic ILAS is a frequent finding on neuroimaging and shares many r…
View article: Hypothalamic Gliosis Is Associated With Multiple Cardiovascular Disease Risk Factors in the Framingham Heart Study
Hypothalamic Gliosis Is Associated With Multiple Cardiovascular Disease Risk Factors in the Framingham Heart Study Open
Background Hypothalamic gliosis is mechanistically linked to obesity and insulin resistance in rodent models. We tested cross‐sectional associations between radiologic measures of hypothalamic gliosis in humans and clinically relevant card…
View article: Selected social and lifestyle correlates of brain health markers: the Cross‐Cohort Collaboration Consortium
Selected social and lifestyle correlates of brain health markers: the Cross‐Cohort Collaboration Consortium Open
INTRODUCTION To investigate the associations of education level, marital status, and physical activity with dementia risk and brain MRI markers. METHODS Data from six community‐based samples from the Cross‐Cohort Collaboration Consortium w…
View article: Clinical and Imaging Markers of Cardiac Function and Brain Health
Clinical and Imaging Markers of Cardiac Function and Brain Health Open
In this large study among community-dwelling adults, subclinical cardiac dysfunction was associated with brain imaging markers of neurodegeneration. These findings encourage longitudinal investigations on the effect of maintaining cardiac …
View article: Education Levels and Poststroke Cognitive Trajectories
Education Levels and Poststroke Cognitive Trajectories Open
Importance Acute stroke is associated with accelerated, years-long cognitive decline. Whether education levels are associated with faster cognitive decline after stroke is unclear. Objective To evaluate the association of education level w…
View article: Adherence to Life’s Essential 8 Enhances Gut Microbiota Diversity and Cognitive Performance
Adherence to Life’s Essential 8 Enhances Gut Microbiota Diversity and Cognitive Performance Open
Emerging evidence suggests a complex interplay among cardiovascular health, gut microbiome composition, and cognitive function. Life’s Essential 8 (LE8), developed by the American Heart Association, includes vital metrics of cardiovascular…
View article: Genomics of diffusion-imaging integrating GWAS, exome data and single-cell sequencing unravels lifespan determinants of cerebral small vessel disease
Genomics of diffusion-imaging integrating GWAS, exome data and single-cell sequencing unravels lifespan determinants of cerebral small vessel disease Open
Peak width of skeletonized mean diffusivity (PSMD) is an emerging automated diffusion imaging marker showing clinically relevant changes in cerebral small vessel disease (cSVD), a leading cause of stroke and dementia with no mechanism-base…
View article: Long Sleep Duration, Cognitive Performance, and the Moderating Role of Depression: A Cross-Sectional Analysis in the Framingham Heart Study
Long Sleep Duration, Cognitive Performance, and the Moderating Role of Depression: A Cross-Sectional Analysis in the Framingham Heart Study Open
INTRODUCTION We investigated whether depression modified the associations between sleep duration and cognitive performance. METHODS Multivariable linear regression models examined the associations between sleep duration and cognition in 1,…
View article: Are there trends towards compression of morbidity for dementia? Evidences from four international population‐based cohorts
Are there trends towards compression of morbidity for dementia? Evidences from four international population‐based cohorts Open
Background Dementia is a major contributor to loss of autonomy in the elderly. Every year spent with dementia results in significant medical and societal costs. Understanding secular trends of life expectancy with and without dementia woul…
View article: Rethinking the residual approach for estimating cognitive resilience and resistance to AD pathology
Rethinking the residual approach for estimating cognitive resilience and resistance to AD pathology Open
Background The residual approach has found wide application in researching cognitive resilience, a phenomenon conceptually understood as cognitive performance being better‐than‐typical for an individual, despite apparent AD pathology. The …
View article: Examining early cerebral amyloid beta and tau accumulation in association with cognition in a predominantly middle‐aged cohort
Examining early cerebral amyloid beta and tau accumulation in association with cognition in a predominantly middle‐aged cohort Open
Background In older adults, greater amyloid (Aβ) and tau positron emission tomography (PET) binding is associated with cognitive decline and dementia. However, the association of early amyloid and tau PET accumulation with cognition at mid…
View article: Instrumental and biological validation of PSMD as a VCID biomarker
Instrumental and biological validation of PSMD as a VCID biomarker Open
Background Peak‐width of skeletonized mean diffusivity (PSMD) is an emerging biomarker of cerebral small vessel disease (cSVD)‐related vascular contributions to cognitive impairment and dementia (VCID). Higher PSMD values reflect greater w…
View article: Sleep Duration and Cognitive Performance in Middle‐Aged and Older Adults: What is the Role of Depression?
Sleep Duration and Cognitive Performance in Middle‐Aged and Older Adults: What is the Role of Depression? Open
Background Recent research has highlighted the importance of sleep on cognitive processes. However, conflicting evidence exists regarding optimal sleep duration and the impact of other co‐occurring conditions, such as depression. A diagnos…
View article: Relation Between Educational Attainment and Cerebral Small Vessel Disease: the Framingham Heart Study
Relation Between Educational Attainment and Cerebral Small Vessel Disease: the Framingham Heart Study Open
Background Socioeconomic factors have an impact on long‐term neurovascular health. Education attainment (EA) is a socioeconomic factor which may be related to vascular risk factors and brain health. We investigated the relation of EA and c…