Importance Acute stroke is associated with accelerated, years-long cognitive decline. Whether education levels are associated with faster cognitive decline after stroke is unclear. Objective To evaluate the association of education level with poststroke cognitive decline and to determine whether age at stroke modifies the association. Design, Setting, and Participants Individual participant data meta-analysis of 4 US cohort studies (January 1971 to December 2019). Analysis began August 2022 and was completed in Ja…

Abstract INTRODUCTION To investigate the associations of education level, marital status, and physical activity with dementia risk and brain MRI markers. METHODS Data from six community‐based samples from the Cross‐Cohort Collaboration Consortium were analyzed. Self‐reported education level, marital status, and physical activity at age 60 to 75 years were harmonized. Subsamples of participants with brain MRI markers at time of exposure were selected. Associations with dementia risk and cross‐sectional MRI markers …

In this large study among community-dwelling adults, subclinical cardiac dysfunction was associated with brain imaging markers of neurodegeneration. These findings encourage longitudinal investigations on the effect of maintaining cardiac function on brain health.

We found a significant association between all-cause dementia and multimarker CSVD scores, which was independent of the FSRP as well as its individual components. Our results support the use of a multimarker CSVD score as an indicator for incident all-cause dementia risk and suggest that it may be as robust as the FSRP. Further studies are necessary to validate the use of a multimarker CSVD score in dementia risk prediction.

Objective In men and women, sex steroid hormones have been associated with increased risk of Alzheimer's disease (AD) dementia. We aimed to investigate the influence of midlife testosterone and sex hormone binding globulin (SHBG) levels on later‐life in vivo markers of β‐amyloid (Aβ) and tau deposition in clinically healthy older men. Methods This time‐lagged study includes participants enrolled in the Framingham Heart Study (FHS) Third Generation cohort. One hundred fifty‐nine men (mean age PET‐scan = 58 [±/9] ye…