Alexander Assmann
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View article: Microaxial pump‐supported coronary surgery without CPB to optimize outcome in severely impaired left ventricles
Microaxial pump‐supported coronary surgery without CPB to optimize outcome in severely impaired left ventricles Open
Aims Cardiopulmonary bypass (CPB) is the standard approach for coronary artery bypass grafting (CABG) in advanced ischaemic cardiomyopathy. Microaxial pump support has been envisioned to allow for beating‐heart CABG without CPB (MPCAB), th…
View article: MRI-based Quantitative Aortic Blood Flow Analysis in a Rabbit Model During Ante- and Retrograde Extracorporeal Circulation
MRI-based Quantitative Aortic Blood Flow Analysis in a Rabbit Model During Ante- and Retrograde Extracorporeal Circulation Open
Background: Although extracorporeal circulation (ECC) is routinely used during cardiac surgery, the optimal ECC cannulation strategy is still under debate. Therefore, we used our previously published miniaturized magnetic resonance imaging…
View article: Verification of the presence of superabsorbent polymer (SAP) in fresh concrete: results of an interlaboratory study
Verification of the presence of superabsorbent polymer (SAP) in fresh concrete: results of an interlaboratory study Open
New methods are proposed for the verification of the presence of superabsorbent polymers (SAP) in freshly mixed concrete and estimation of SAP quantity. The methods are in general based on flushing concrete with excess water. They allow se…
View article: The impact of socio-demographic factors on health-related quality of life after coronary artery bypass surgery
The impact of socio-demographic factors on health-related quality of life after coronary artery bypass surgery Open
OBJECTIVES To achieve a beneficial impact on long-term outcome after coronary artery bypass grafting (CABG), the goal of the present study was the early identification of patients at risk of impaired postoperative health-related quality of…
View article: Establishment of a Rabbit Model for MRI-Based Blood Flow Analysis under Extracorporeal Circulation
Establishment of a Rabbit Model for MRI-Based Blood Flow Analysis under Extracorporeal Circulation Open
Background: The choice of the optimal extracorporeal circulation (ECC) cannulation strategy is still under debate. To allow for visualization and exact measurements of the impact of different ECC scenarios on the arterial blood flow, magne…
View article: Impact of PPAR-gamma activation on the durability of biological heart valve prostheses in hypercholesterolaemic rats
Impact of PPAR-gamma activation on the durability of biological heart valve prostheses in hypercholesterolaemic rats Open
OBJECTIVES Hypercholesterolaemia and obesity are risk factors for the development of calcified aortic valve disease and common comorbidities in respective patients. Peroxisome proliferator-activated receptor gamma activation has been shown…
View article: Degeneration of biological heart valve grafts in a rat model of superoxide dismutase‐3 deficiency
Degeneration of biological heart valve grafts in a rat model of superoxide dismutase‐3 deficiency Open
While oxidative stress is known as key element in the pathogenesis of atherosclerosis and calcific aortic valve disease, its role in the degeneration of biological cardiovascular grafts has not been clarified yet. Therefore, the present st…
View article: Use of extracorporeal circulation (ECLS/ECMO) for cardiac and circulatory failure –A clinical practice Guideline Level 3
Use of extracorporeal circulation (ECLS/ECMO) for cardiac and circulatory failure –A clinical practice Guideline Level 3 Open
Aims Worldwide applications of extracorporeal circulation for mechanical support in cardiac and circulatory failure, which are referred to as extracorporeal life support (ECLS) or veno‐arterial extracorporeal membrane oxygenation (va‐ECMO)…
View article: A Role for Peroxisome Proliferator-Activated Receptor Gamma Agonists in Counteracting the Degeneration of Cardiovascular Grafts
A Role for Peroxisome Proliferator-Activated Receptor Gamma Agonists in Counteracting the Degeneration of Cardiovascular Grafts Open
Aortic valve replacement for severe stenosis is a standard procedure in cardiovascular medicine. However, the use of biological prostheses has limitations especially in young patients because of calcifying degeneration, resulting in implan…
View article: Initial experience covering 50 consecutive cases of large Impella implantation at a single heart centre
Initial experience covering 50 consecutive cases of large Impella implantation at a single heart centre Open
Aims Pre‐operative or post‐operative heart failure (HF) and cardiogenic shock of various natures frequently remain refractory to conservative treatment and require mechanical circulatory support. We report our clinical experience with larg…
View article: Coronary artery bypass grafting under sole Impella 5.0 support for patients with severely depressed left ventricular function
Coronary artery bypass grafting under sole Impella 5.0 support for patients with severely depressed left ventricular function Open
Selection of the ideal surgical procedure for coronary revascularization in patients with severe cardiac dysfunction at times may represent a challenge. In recent years, with the advent of surgical large microaxial pumps, e.g., Impella 5.0…
View article: Controlled autologous recellularization and inhibited degeneration of decellularized vascular implants by side-specific coating with stromal cell-derived factor 1α and fibronectin
Controlled autologous recellularization and inhibited degeneration of decellularized vascular implants by side-specific coating with stromal cell-derived factor 1α and fibronectin Open
Optimized biocompatibility is crucial for the durability of cardiovascular implants. Previously, a combined coating with fibronectin (FN) and stromal cell-derived factor 1 α (SDF1 α ) has been shown to accelerate the in vivo cellularizatio…
View article: Computational investigation of hemodynamics in hardshell venous reservoirs: A comparative study
Computational investigation of hemodynamics in hardshell venous reservoirs: A comparative study Open
Extracorporeal circulation using heart‐lung‐machines is associated with a profound activation of corpuscular and plasmatic components of circulating blood, which can also lead to deleterious events such as systemic inflammatory response an…
View article: Influence of Laminin Coating on the Autologous In Vivo Recellularization of Decellularized Vascular Protheses
Influence of Laminin Coating on the Autologous In Vivo Recellularization of Decellularized Vascular Protheses Open
Decellularization of non-autologous biological implants reduces the immune response against foreign tissue. Striving for in vivo repopulation of aortic prostheses with autologous cells, thereby improving the graft biocompatibility, we exam…
View article: Muscular Mitral Chord Contribution to Left Ventricular Outflow Tract Obstruction in HOCM
Muscular Mitral Chord Contribution to Left Ventricular Outflow Tract Obstruction in HOCM Open
Papillary muscle anomaly with a muscular chord directly attached to the anterior mitral leaflet is a rare mitral valve disease. A 62-year-old man with systolic anterior motion of the anterior mitral leaflet and hypertrophic obstructive car…
View article: Organization and Application of ECLS Therapy—A Nationwide Survey in German Cardiosurgical Departments
Organization and Application of ECLS Therapy—A Nationwide Survey in German Cardiosurgical Departments Open
Background In context of the multidisciplinary German scientific guideline “Use of extracorporeal circulation (extracorporeal life support [ECLS]/extracorporeal membrane oxygenation) for cardiac and circulatory failure,” a nationwide surve…
View article: Development of an Elastic and Adhesive Sealant for Surgical Applications
Development of an Elastic and Adhesive Sealant for Surgical Applications Open
Author(s): Annabi, N; Zhang, Y; Assmann, A; Sani, E Shirzaei; Vegh, A; Cheng, G; Dehghani, B; Ruiz-Esparza, GU; Wang, X; Lassaletta, AS; Gangadharan, S; Weiss, AS; Khademhosseini, A
View article: Engineering a highly elastic human protein–based sealant for surgical applications
Engineering a highly elastic human protein–based sealant for surgical applications Open
A highly elastic and adhesive photocrosslinkable surgical sealant using a modified human protein controls liquid leakages without the need for suturing.
View article: Focal induction of ROS-release to trigger local vascular degeneration
Focal induction of ROS-release to trigger local vascular degeneration Open
Reactive oxygen species (ROS) play an important role in the process of cardiovascular degeneration. We evaluated the potential of a controlled, local induction of ROS-release by application of rose bengal (RB) and photo energy to induce at…
View article: Assessment of decellularization of heart bioimplants using a Raman spectroscopy method
Assessment of decellularization of heart bioimplants using a Raman spectroscopy method Open
We report the results of experimental studies on cardiac implants using a Raman spectroscopy method (RS). Raman spectra characteristics of leaves and walls of cardiac implants were obtained; the implants were manufactured by protocols of d…
View article: Acute chest pain in a triathlete: rupture of the noncoronary sinus of Valsalva into the right ventricle
Acute chest pain in a triathlete: rupture of the noncoronary sinus of Valsalva into the right ventricle Open
Sinus of Valsalva (SoV) aneurysm is a rare cardiac disease which can be congenital or acquired. A ruptured SoV aneurysm presents a clinical emergency and can lead to progressively deteriorating heart failure. Therefore, appropriate treatme…