Alexander Aulehla
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View article: A noncanonical role of glycolytic metabolites controlling the timing of mouse embryo segmentation
A noncanonical role of glycolytic metabolites controlling the timing of mouse embryo segmentation Open
Studies on the impact of metabolism on cell fate decisions are seeing a renaissance. However, a key challenge remains to distinguish signaling functions of metabolism from its canonical bioenergetic and biosynthetic roles, which underlie c…
View article: Nonreciprocal synchronization in embryonic oscillator ensembles
Nonreciprocal synchronization in embryonic oscillator ensembles Open
Synchronization of coupled oscillators is a universal phenomenon encountered across different scales and contexts, e.g., chemical wave patterns, superconductors, and the unison applause we witness in concert halls. The existence of common …
View article: Modular control of vertebrate axis segmentation in time and space
Modular control of vertebrate axis segmentation in time and space Open
How the timing of development is linked to organismal size is a longstanding question. Although numerous studies have reported a correlation of temporal and spatial traits, the developmental or selective constraints underlying this link re…
View article: Multi-species community platform for comparative neuroscience in teleost fish
Multi-species community platform for comparative neuroscience in teleost fish Open
Studying neural mechanisms in complementary model organisms from different ecological niches in the same animal class can leverage the comparative brain analysis at the cellular level. To advance such a direction, we developed a unified br…
View article: Nonreciprocal synchronization in embryonic oscillator ensembles
Nonreciprocal synchronization in embryonic oscillator ensembles Open
Synchronization of coupled oscillators is a universal phenomenon encountered across different scales and contexts e.g., chemical wave patterns, superconductors and the unison applause we witness in concert halls. The existence of common un…
View article: Glycolysis–Wnt signaling axis tunes developmental timing of embryo segmentation
Glycolysis–Wnt signaling axis tunes developmental timing of embryo segmentation Open
The question of how metabolism impacts development is seeing a renaissance [1, 2]. How metabolism exerts instructive signaling functions is one of the central issues that need to be resolved. We tackled this question in the context of mous…
View article: Modular control of time and space during vertebrate axis segmentation
Modular control of time and space during vertebrate axis segmentation Open
How temporal and spatial control of developmental processes are linked remains a fundamental question. Do underlying mechanisms form a single functional unit or are these dissociable modules? We address this question by studying the period…
View article: Glycolytic flux-signaling controls mouse embryo mesoderm development
Glycolytic flux-signaling controls mouse embryo mesoderm development Open
How cellular metabolic state impacts cellular programs is a fundamental, unresolved question. Here, we investigated how glycolytic flux impacts embryonic development, using presomitic mesoderm (PSM) patterning as the experimental model. Fi…
View article: Author response: Glycolytic flux-signaling controls mouse embryo mesoderm development
Author response: Glycolytic flux-signaling controls mouse embryo mesoderm development Open
View article: Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock
Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock Open
Living systems exhibit an unmatched complexity, due to countless, entangled interactions across scales. Here, we aim to understand a complex system, that is, segmentation timing in mouse embryos, without a reference to these detailed inter…
View article: Author response: Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock
Author response: Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Living syst…
View article: Imaging the onset of oscillatory signaling dynamics during mouse embryo gastrulation
Imaging the onset of oscillatory signaling dynamics during mouse embryo gastrulation Open
A fundamental requirement for embryonic development is the coordination of signaling activities in space and time. A notable example in vertebrate embryos is found during somitogenesis, where gene expression oscillations linked to the segm…
View article: Glycolytic flux-signaling controls mouse embryo mesoderm development
Glycolytic flux-signaling controls mouse embryo mesoderm development Open
How cellular metabolic state impacts cellular programs is a fundamental, unresolved question. Here we investigated how glycolytic flux impacts embryonic development, using presomitic mesoderm (PSM) patterning as the experimental model. Fir…
View article: Author response: Endogenous protein tagging in medaka using a simplified CRISPR/Cas9 knock-in approach
Author response: Endogenous protein tagging in medaka using a simplified CRISPR/Cas9 knock-in approach Open
View article: Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock
Arnold tongue entrainment reveals dynamical principles of the embryonic segmentation clock Open
Living systems exhibit an unmatched complexity, due to countless, entangled interactions across scales. Here we aim to understand a complex system, i.e. segmentation timing in mouse embryos, without a reference to these detailed interactio…
View article: Endogenous protein tagging in medaka using a simplified CRISPR/Cas9 knock-in approach
Endogenous protein tagging in medaka using a simplified CRISPR/Cas9 knock-in approach Open
The CRISPR/Cas9 system has been used to generate fluorescently labelled fusion proteins by homology directed repair in a variety of species. Despite its revolutionary success, there remains an urgent need for increased simplicity and effic…
View article: Revisiting the role of metabolism during development
Revisiting the role of metabolism during development Open
An emerging view emphasizes that metabolism is highly regulated in both time and space. In addition, it is increasingly being recognized that metabolic pathways are tightly connected to specific biological processes such as cell signaling,…
View article: Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation
Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation Open
View article: Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development
Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development Open
How metabolism is rewired during embryonic development is still largely unknown, as it remains a major technical challenge to resolve metabolic activities or metabolite levels with spatiotemporal resolution. Here, we investigated metabolic…
View article: Metabolic Control of Cellular Differentiation
Metabolic Control of Cellular Differentiation Open
View article: Self-Organization of Embryonic Genetic Oscillators into Spatiotemporal Wave Patterns
Self-Organization of Embryonic Genetic Oscillators into Spatiotemporal Wave Patterns Open