Alexander Bartel
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View article: Artificial intelligence predicts <i>c-KIT</i> exon 11 genotype by phenotype in canine cutaneous mast cell tumors: Can human observers learn it?
Artificial intelligence predicts <i>c-KIT</i> exon 11 genotype by phenotype in canine cutaneous mast cell tumors: Can human observers learn it? Open
Canine cutaneous mast cell tumors (ccMCTs) are frequent neoplasms with variable biological behaviors. Internal tandem duplication mutations in c-KIT exon 11 ( c-KIT -11-ITD) are associated with poor prognosis but predict therapeutic respon…
View article: Drying-off practices and cell count –based new infection and cure risk over the dry period on 765 German dairy farms
Drying-off practices and cell count –based new infection and cure risk over the dry period on 765 German dairy farms Open
View article: Effective Inhibitor Removal from Wastewater Samples Increases Sensitivity of RT-dPCR and Sequencing Analyses and Enhances the Stability of Wastewater-Based Surveillance
Effective Inhibitor Removal from Wastewater Samples Increases Sensitivity of RT-dPCR and Sequencing Analyses and Enhances the Stability of Wastewater-Based Surveillance Open
Wastewater-based surveillance (WBS) is a proven tool for monitoring population-level infection events. Wastewater contains high concentrations of inhibitors, which contaminate the total nucleic acids (TNA) extracted from these samples. We …
View article: Expression of Mutated BRAFV595E Kinase in Canine Carcinomas—An Immunohistochemical Study
Expression of Mutated BRAFV595E Kinase in Canine Carcinomas—An Immunohistochemical Study Open
Alterations of the BRAF gene and the resulting changes in the BRAF protein are one example of molecular cancer profiling in humans and dogs. We tested 227 samples of canine carcinomas from different anatomical sites (anal sac (n = 23), int…
View article: Nuclear pleomorphism in canine cutaneous mast cell tumors: Comparison of reproducibility and prognostic relevance between estimates, manual morphometry, and algorithmic morphometry
Nuclear pleomorphism in canine cutaneous mast cell tumors: Comparison of reproducibility and prognostic relevance between estimates, manual morphometry, and algorithmic morphometry Open
Variation in nuclear size and shape is an important criterion of malignancy for many tumor types; however, categorical estimates by pathologists have poor reproducibility. Measurements of nuclear characteristics can improve reproducibility…
View article: Third-generation cephalosporin resistant Escherichia coli in dogs and cats in Germany in 2019–2021
Third-generation cephalosporin resistant Escherichia coli in dogs and cats in Germany in 2019–2021 Open
Objectives Antimicrobial resistance (AMR) poses a worldwide challenge, threatening global health. The objective of this research was to determine the 3 rd generation cephalosporin resistance (3GCR) proportion in Escherichia (E . ) coli iso…
View article: Do concentrations of non‐esterified fatty acids change during gestation and lactation in healthy bitches?
Do concentrations of non‐esterified fatty acids change during gestation and lactation in healthy bitches? Open
During the gestation and lactation period, the energy demand in pregnant and lactating bitches is elevated. Non‐esterified fatty acids (NEFAs) are utilized either directly from the fed diet or from body fat storage. High NEFA concentration…
View article: Comparative Analysis of Methicillin-Resistant Staphylococcus pseudintermedius Prevalence and Resistance Patterns in Canine and Feline Clinical Samples: Insights from a Three-Year Study in Germany
Comparative Analysis of Methicillin-Resistant Staphylococcus pseudintermedius Prevalence and Resistance Patterns in Canine and Feline Clinical Samples: Insights from a Three-Year Study in Germany Open
The emergence of methicillin-resistant Staphylococcus pseudintermedius (MRSP) presents a significant public health concern globally, particularly within veterinary medicine. MRSP’s resistance to multiple antibiotics is limiting treatment o…
View article: The relationship between lameness prevalence and pasture access in 659 dairy herds in Germany
The relationship between lameness prevalence and pasture access in 659 dairy herds in Germany Open
Lameness in dairy cows is an expression of pain most likely originating from a claw disorder, causing impaired animal wellbeing and substantial economic losses for farmers. The aim of this study was to investigate the effects of access to …
View article: Automated Nuclear Morphometry: A Deep Learning Approach for Prognostication in Canine Pulmonary Carcinoma to Enhance Reproducibility
Automated Nuclear Morphometry: A Deep Learning Approach for Prognostication in Canine Pulmonary Carcinoma to Enhance Reproducibility Open
The integration of deep learning-based tools into diagnostic workflows is increasingly prevalent due to their efficiency and reproducibility in various settings. We investigated the utility of automated nuclear morphometry for assessing nu…
View article: Mitotic activity: A systematic literature review of the assessment methodology and prognostic value in feline tumors
Mitotic activity: A systematic literature review of the assessment methodology and prognostic value in feline tumors Open
Increased proliferation is a driver of tumorigenesis, and quantification of mitotic activity is a standard task for prognostication. This systematic review is an analysis of all available references on mitotic activity in feline tumors to …
View article: Mitotic activity: A systematic literature review of the assessment methodology and prognostic value in canine tumors
Mitotic activity: A systematic literature review of the assessment methodology and prognostic value in canine tumors Open
One of the most relevant prognostic indices for tumors is cellular proliferation, which is most commonly measured by the mitotic activity in routine tumor sections. The goal of this systematic review was to analyze the methods and prognost…
View article: Blood‐based assessment of oxidative stress, inflammation, endocrine and metabolic adaptations in eventing horses accounting for plasma volume shift after exercise
Blood‐based assessment of oxidative stress, inflammation, endocrine and metabolic adaptations in eventing horses accounting for plasma volume shift after exercise Open
Background After submaximal exercise, blood values of eventing horses show physiological reactions. Objectives This prospective longitudinal study investigated blood parameters in 20 elite eventing horses before and after two–four‐star cro…
View article: Impact of air humidity on the tenacity of different agents in bioaerosols
Impact of air humidity on the tenacity of different agents in bioaerosols Open
Despite the variety of pathogens that are transmitted via the airborne route, few data are available on factors that influence the tenacity of airborne pathogens. In order to better understand and thus control airborne infections, knowledg…
View article: Timely Monitoring of SARS-CoV-2 RNA Fragments in Wastewater Shows the Emergence of JN.1 (BA.2.86.1.1, Clade 23I) in Berlin, Germany
Timely Monitoring of SARS-CoV-2 RNA Fragments in Wastewater Shows the Emergence of JN.1 (BA.2.86.1.1, Clade 23I) in Berlin, Germany Open
The importance of COVID-19 surveillance from wastewater continues to grow since case-based surveillance in the general population has been scaled back world-wide. In Berlin, Germany, quantitative and genomic wastewater monitoring for SARS-…
View article: Abstract: Cytologic Scoring of Equine Exercise-induced Pulmonary Hemorrhage
Abstract: Cytologic Scoring of Equine Exercise-induced Pulmonary Hemorrhage Open
View article: Atypical Mitotic Figures Are Prognostically Meaningful for Canine Cutaneous Mast Cell Tumors
Atypical Mitotic Figures Are Prognostically Meaningful for Canine Cutaneous Mast Cell Tumors Open
Cell division through mitosis (microscopically visible as mitotic figures, MFs) is a highly regulated process. However, neoplastic cells may exhibit errors in chromosome segregation (microscopically visible as atypical mitotic figures, AMF…
View article: Clicker Training as an Applied Refinement Measure in Chickens
Clicker Training as an Applied Refinement Measure in Chickens Open
When using chickens in animal studies, the handling of these animals for sample collection or general examinations is considered stressful due to their prey nature. For the study presented here, plasma and salivary corticosterone as well a…
View article: Stability of Feline Coronavirus in aerosols and dried in organic matrices on surfaces at various environmental conditions
Stability of Feline Coronavirus in aerosols and dried in organic matrices on surfaces at various environmental conditions Open
Enveloped respiratory viruses, including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can be transmitted through aerosols and contact with contaminated surfaces. The stability of these viruses outside the host signific…
View article: Blood-Based Markers for Skeletal and Cardiac Muscle Function in Eventing Horses before and after Cross-Country Rides and How They Are Influenced by Plasma Volume Shift
Blood-Based Markers for Skeletal and Cardiac Muscle Function in Eventing Horses before and after Cross-Country Rides and How They Are Influenced by Plasma Volume Shift Open
Horses competing in cross-country tests are subjected to high physical demands. Within the scope of this prospective longitudinal study, blood values of 20 elite eventing horses were examined before and after two- to four-star cross-countr…
View article: Nuclear Pleomorphism in Canine Cutaneous Mast Cell Tumors: Comparison of Reproducibility and Prognostic Relevance between Estimates, Manual Morphometry and Algorithmic Morphometry
Nuclear Pleomorphism in Canine Cutaneous Mast Cell Tumors: Comparison of Reproducibility and Prognostic Relevance between Estimates, Manual Morphometry and Algorithmic Morphometry Open
Variation in nuclear size and shape is an important criterion of malignancy for many tumor types; however, categorical estimates by pathologists have poor reproducibility. Measurements of nuclear characteristics (morphometry) can improve r…
View article: Listening, reading, writing – which method leads to the best learning outcome?
Listening, reading, writing – which method leads to the best learning outcome? Open
Objective Innovative teaching strategies such as case-based learning and hands-on training are more and more integrated into undergraduate veterinary teaching. Nevertheless, it can be assumed that lectures still play an important role in m…
View article: Automated diagnosis of 7 canine skin tumors using machine learning on H&E-stained whole slide images
Automated diagnosis of 7 canine skin tumors using machine learning on H&E-stained whole slide images Open
Microscopic evaluation of hematoxylin and eosin-stained slides is still the diagnostic gold standard for a variety of diseases, including neoplasms. Nevertheless, intra- and interrater variability are well documented among pathologists. So…
View article: Estimated incubation period distributions of mpox using cases from two international European festivals and outbreaks in a club in Berlin, May to June 2022
Estimated incubation period distributions of mpox using cases from two international European festivals and outbreaks in a club in Berlin, May to June 2022 Open
Background Since May 2022, an mpox outbreak affecting primarily men who have sex with men (MSM) has occurred in numerous non-endemic countries worldwide. As MSM frequently reported multiple sexual encounters in this outbreak, reliably dete…
View article: Seroprevalence of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum Infections in German Horses
Seroprevalence of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum Infections in German Horses Open
There are limited data on Lyme borreliosis (LB), a tick-borne disease caused by the Borrelia burgdorferi sensu lato complex, in horses. Seropositivity is not necessarily associated with clinical disease. Data on seropositivity against Borr…
View article: Systematic Review of Methods and Prognostic Value of Mitotic Activity. Part 2: Canine Tumors
Systematic Review of Methods and Prognostic Value of Mitotic Activity. Part 2: Canine Tumors Open
One of the most relevant prognostication tests for tumors is cellular proliferation, which is most commonly measured by the mitotic activity in routine tumor sections. The goal of this systematic review is to scholarly analyze the methods …
View article: Pre-Ride Biomarkers and Endurance Horse Welfare: Analyzing the Impact of the Elimination of Superoxide Dismutase, δ-Aminolevulinic-Dehydratase, Thiobarbituric Acid Reactive Substances, Iron, and Serum Amyloid A Levels in Elite 160 km Endurance Rides
Pre-Ride Biomarkers and Endurance Horse Welfare: Analyzing the Impact of the Elimination of Superoxide Dismutase, δ-Aminolevulinic-Dehydratase, Thiobarbituric Acid Reactive Substances, Iron, and Serum Amyloid A Levels in Elite 160 km Endurance Rides Open
High elimination rates and concerns for horse welfare are important issues in endurance riding. Improved understanding of the causes of elimination could increase completion rates in this sport. We have identified pre-ride laboratory risk …
View article: Status of udder health performance indicators and implementation of on farm monitoring on German dairy cow farms: results from a large scale cross-sectional study
Status of udder health performance indicators and implementation of on farm monitoring on German dairy cow farms: results from a large scale cross-sectional study Open
Regional benchmarking data enables farmers to compare their animal health situation to that of other herds and identify areas with improvement potential. For the udder health status of German dairy cow farms, such data were incomplete. The…
View article: Metabolomics during canine pregnancy and lactation
Metabolomics during canine pregnancy and lactation Open
During pregnancy and parturition, female dogs have to cope with various challenges such as providing nutrients for the growth of the fetuses, hormonal changes, whelping, nursing, milk production, and uterine involution. Metabolomic researc…
View article: Systematic Review of Methods and Prognostic Value of Mitotic Activity. Part 1: Feline Tumors
Systematic Review of Methods and Prognostic Value of Mitotic Activity. Part 1: Feline Tumors Open
Increased proliferation is a key driver of tumorigenesis, and quantification of mitotic activity is a standard task for prognostication. The goal of this systematic review is scholarly analysis of all available references on mitotic activi…