Alexander Blood
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View article: Manual vs AI-Assisted Prescreening for Trial Eligibility Using Large Language Models—A Randomized Clinical Trial
Manual vs AI-Assisted Prescreening for Trial Eligibility Using Large Language Models—A Randomized Clinical Trial Open
This randomized clinical trial compares the efficiency of prescreening patients with heart failure using an artificial intelligence (AI) large language model for inclusion in a clinical trial vs manual prescreening.
View article: Integrating Ambulatory Care Pharmacists Into Value-Based Primary Care: A Scalable Solution to Chronic Disease
Integrating Ambulatory Care Pharmacists Into Value-Based Primary Care: A Scalable Solution to Chronic Disease Open
Introduction/Objectives: Patients living with chronic diseases require more medical attention, including more visits to primary care. However, primary care providers are overburdened, and this specialty is attracting fewer new providers th…
View article: Contemporary treatment patterns of overweight and obesity: insights from the Mass General Brigham health care system
Contemporary treatment patterns of overweight and obesity: insights from the Mass General Brigham health care system Open
Objective The objective of this study was to describe the prevalence of obesity, obesity‐related conditions (ORCs), and antiobesity medication (AOM) eligibility and prescribing practice among eligible patients in a large health care system…
View article: Identifying Patients with Heart Failure Eligible for Guideline-Directed Medical Therapy
Identifying Patients with Heart Failure Eligible for Guideline-Directed Medical Therapy Open
A majority of patients with heart failure (HF) do not receive adequate medical therapy as recommended by clinical guidelines. One major obstacle encountered by population health management (PHM) programs to improve medication usage is the …
View article: Detection of hypertrophic cardiomyopathy on electrocardiogram using artificial intelligence
Detection of hypertrophic cardiomyopathy on electrocardiogram using artificial intelligence Open
Background Hypertrophic cardiomyopathy (HCM) is associated with significant morbidity and mortality including sudden cardiac death in the young. Its prevalence is estimated to be 1 in 500, although many people are undiagnosed. The ability …
View article: What Constitutes Adequate Control of High Blood Pressure? Current Considerations
What Constitutes Adequate Control of High Blood Pressure? Current Considerations Open
An estimated 45% of adult Americans currently have high blood pressure (HBP). Effective blood pressure (BP) control is essential for preventing major adverse events from cardiovascular and other vascular-related diseases, such as chronic k…
View article: Retrieval-Augmented Generation–Enabled GPT-4 for Clinical Trial Screening
Retrieval-Augmented Generation–Enabled GPT-4 for Clinical Trial Screening Open
BackgroundScreening participants in clinical trials is an error-prone and labor-intensive process that requires significant time and resources. Large language models such as generative pretrained transformer 4 (GPT-4) present an opportunit…
View article: Retrieval Augmented Generation Enabled Generative Pre-Trained Transformer 4 (GPT-4) Performance for Clinical Trial Screening
Retrieval Augmented Generation Enabled Generative Pre-Trained Transformer 4 (GPT-4) Performance for Clinical Trial Screening Open
Background Subject screening is a key aspect of all clinical trials; however, traditionally, it is a labor-intensive and error-prone task, demanding significant time and resources. With the advent of large language models (LLMs) and relate…
View article: Methods, rationale, and design for a remote pharmacist and navigator-driven disease management program to improve guideline-directed medical therapy in patients with type 2 diabetes at elevated cardiovascular and/or kidney risk
Methods, rationale, and design for a remote pharmacist and navigator-driven disease management program to improve guideline-directed medical therapy in patients with type 2 diabetes at elevated cardiovascular and/or kidney risk Open
We are testing a remote, navigator-driven, pharmacist-led, and physician-overseen management strategy to optimize GDMT for T2D as a population-level strategy to close the gap between guidelines and clinical practice for patients with T2D a…
View article: Enrollment strategies in the era of digital revolution: Experience from a remote health management program (Preprint)
Enrollment strategies in the era of digital revolution: Experience from a remote health management program (Preprint) Open
BACKGROUND Remote or decentralized clinical studies allow innovative outreach opportunities, but whether that will result in improved enrollment remains unknown. OBJECTIVE We report our experience in identifying potential participants f…
View article: Implementation of a Scalable Online Weight Management Programme in Clinical Settings: Protocol for the PROPS 2.0 Programme (Partnerships for Reducing Overweight and Obesity with Patient-Centered Strategies 2.0)
Implementation of a Scalable Online Weight Management Programme in Clinical Settings: Protocol for the PROPS 2.0 Programme (Partnerships for Reducing Overweight and Obesity with Patient-Centered Strategies 2.0) Open
Introduction There is an urgent need for scalable strategies for treating overweight and obesity in clinical settings. PROPS 2.0 (Partnerships for Reducing Overweight and Obesity with Patient-Centered Strategies 2.0) aims to adapt and impl…
View article: Postoperative outcomes, predictors and trends of mortality and morbidity in patients undergoing hip fracture surgery with underlying aortic stenosis: A nationwide inpatient sample analysis
Postoperative outcomes, predictors and trends of mortality and morbidity in patients undergoing hip fracture surgery with underlying aortic stenosis: A nationwide inpatient sample analysis Open
Background: Hip fractures frequently necessitate hospitalization, especially among patients aged 75 and above who might concurrently suffer from aortic stenosis (AS). This study focuses on postoperative outcomes, potential determinants of …
View article: Remote Cardiovascular Hypertension Program Enhanced Blood Pressure Control During the COVID‐19 Pandemic
Remote Cardiovascular Hypertension Program Enhanced Blood Pressure Control During the COVID‐19 Pandemic Open
Background The COVID‐19 pandemic disrupted traditional health care; one fallout was a drastic decrease in blood pressure (BP) assessment. We analyzed the pandemic's impact on our existing remote hypertension management program's effectiven…
View article: Results of a Remotely Delivered Hypertension and Lipid Program in More Than 10 000 Patients Across a Diverse Health Care Network
Results of a Remotely Delivered Hypertension and Lipid Program in More Than 10 000 Patients Across a Diverse Health Care Network Open
Importance Blood pressure (BP) and cholesterol control remain challenging. Remote care can deliver more effective care outside of traditional clinician-patient settings but scaling and ensuring access to care among diverse populations rema…
View article: Effectiveness of a remote care program in the management of patients with resistant hypertension or multiple medication intolerances
Effectiveness of a remote care program in the management of patients with resistant hypertension or multiple medication intolerances Open
Background A remote hypertension (HTN) program, designed and implemented at Mass General Brigham (MGB), has demonstrated improved HTN control, reduced need for in-person visits, and increased access to care. The program excluded patients w…
View article: I2b2-etl: Python application for importing electronic health data into the informatics for integrating biology and the bedside platform
I2b2-etl: Python application for importing electronic health data into the informatics for integrating biology and the bedside platform Open
Motivation The i2b2 platform is used at major academic health institutions and research consortia for querying for electronic health data. However, a major obstacle for wider utilization of the platform is the complexity of data loading th…
View article: Anticoagulation and Antiplatelet Therapy for Prevention of Venous and Arterial Thrombotic Events in Critically Ill Patients With COVID-19: COVID-PACT
Anticoagulation and Antiplatelet Therapy for Prevention of Venous and Arterial Thrombotic Events in Critically Ill Patients With COVID-19: COVID-PACT Open
Background: The efficacy and safety of prophylactic full-dose anticoagulation and antiplatelet therapy in critically ill COVID-19 patients remain uncertain. Methods: COVID-PACT (Prevention of Arteriovenous Thrombotic Events in Critically-i…
View article: Use of automatic SQL generation interface to enhance transparency and validity of health-data analysis
Use of automatic SQL generation interface to enhance transparency and validity of health-data analysis Open
Analysis of health data typically requires development of queries using structured query language (SQL) by a data-analyst. As the SQL queries are manually created, they are prone to errors. In addition, accurate implementation of the queri…
View article: Workflow Automation for a Virtual Hypertension Management Program
Workflow Automation for a Virtual Hypertension Management Program Open
Objectives Hypertension is a modifiable risk factor for numerous comorbidities and treating hypertension can greatly improve health outcomes. We sought to increase the efficiency of a virtual hypertension management program through workflo…
View article: Artificial intelligence-enabled event adjudication: estimating delayed cardiovascular effects of respiratory viruses
Artificial intelligence-enabled event adjudication: estimating delayed cardiovascular effects of respiratory viruses Open
Healthcare systems ideally should be able to draw lessons from historical data, including whether common exposures are associated with adverse clinical outcomes. Unfortunately, structured clinical data, such as encounter diagnostic codes i…
View article: Outcomes of a Smartphone-based Application with Live Health-Coaching Post-Percutaneous Coronary Intervention
Outcomes of a Smartphone-based Application with Live Health-Coaching Post-Percutaneous Coronary Intervention Open
Background The interval between inpatient hospitalization for symptomatic coronary artery disease (CAD) and post-discharge office consultation is a vulnerable period for adverse events. Methods Content was customized on a smartphone app-ba…