Alexander Borst
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View article: Population Morphology Implies a Common Developmental Blueprint for <i>Drosophila</i> Motion Detectors
Population Morphology Implies a Common Developmental Blueprint for <i>Drosophila</i> Motion Detectors Open
Detailed characterisation of neuronal morphology provides vital clues for understanding the wiring logic and development of neural circuits. As neuron arbours can both span large distances, and be densely interwoven, one major challenge is…
View article: Polyadic synapses introduce unique wiring architectures in T5 cells of Drosophila
Polyadic synapses introduce unique wiring architectures in T5 cells of Drosophila Open
Connectomes provide neuronal wiring diagrams and allow for investigating the detailed synaptic morphology of each connection. In the visual system of Drosophila , T5 cells are the primary motion-sensing neurons in the OFF-pathway and recei…
View article: Differential temporal filtering in the fly optic lobe
Differential temporal filtering in the fly optic lobe Open
Visual interneurons come in many different flavors, representing luminance changes at one location as ON or OFF signals with different dynamics, ranging from purely sustained to sharply transient responses. While the functional relevance o…
View article: Polyadic synapses introduce unique wiring architectures in T5 cells of <i>Drosophila</i>
Polyadic synapses introduce unique wiring architectures in T5 cells of <i>Drosophila</i> Open
Connectomes provide neuronal wiring diagrams and allow for investigating the detailed synaptic morphology of each connection. In the visual system of Drosophila , T5 cells are the primary motion-sensing neurons in the OFF-pathway. On their…
View article: Columnar cholinergic neurotransmission onto T5 cells of Drosophila
Columnar cholinergic neurotransmission onto T5 cells of Drosophila Open
Several nicotinic and muscarinic acetylcholine receptors (AChRs) are expressed in the brain of Drosophila melanogaster. However, the contribution of different AChRs to visual information processing remains poorly understood. T5 cells are t…
View article: Differential temporal filtering in the fly optic lobe
Differential temporal filtering in the fly optic lobe Open
Visual interneurons come in many different flavors, representing luminance changes at one location as ON or OFF signals with different dynamics, ranging from purely sustained to sharply transient responses. While the functional relevance o…
View article: Columnar cholinergic neurotransmission onto T5 cells of<i>Drosophila</i>
Columnar cholinergic neurotransmission onto T5 cells of<i>Drosophila</i> Open
Summary Several nicotinic and muscarinic acetylcholine receptors (AChRs) are expressed in the brain of Drosophila melanogaster . However, the contribution of different AChRs to visual information processing remains poorly understood. T5 ce…
View article: An open platform for visual stimulation of insects
An open platform for visual stimulation of insects Open
To study how the nervous system processes visual information, experimenters must record neural activity while delivering visual stimuli in a controlled fashion. In animals with a nearly panoramic field of view, such as flies, precise stimu…
View article: Connectivity Matrix Seriation via Relaxation
Connectivity Matrix Seriation via Relaxation Open
Volume electron microscopy together with computer-based image analysis are yielding neural circuit diagrams of ever larger regions of the brain. These datasets are usually represented in a cell-to-cell connectivity matrix and contain impor…
View article: Using the Abstract Computer Architecture Description Language to Model AI Hardware Accelerators
Using the Abstract Computer Architecture Description Language to Model AI Hardware Accelerators Open
Artificial Intelligence (AI) has witnessed remarkable growth, particularly through the proliferation of Deep Neural Networks (DNNs). These powerful models drive technological advancements across various domains. However, to harness their p…
View article: Efficient Search for Circuit Structure by ‘Smooth-Index’ Matrix-Reordering
Efficient Search for Circuit Structure by ‘Smooth-Index’ Matrix-Reordering Open
Volume electron microscopy together with computer-based image analysis are yielding neural circuit diagrams of ever larger regions of the brain [1-10]. These datasets are usually represented in a cell-to-cell connectivity matrix and contai…
View article: Super Bowl, an open platform for visual stimulation of insects
Super Bowl, an open platform for visual stimulation of insects Open
To study how the nervous system processes visual information, experimenters must record neural activity while delivering visual stimuli in a controlled fashion. In animals with a nearly panoramic field of view, such as flies, precise stimu…
View article: How Flies See Motion
How Flies See Motion Open
How neurons detect the direction of motion is a prime example of neural computation: Motion vision is found in the visual systems of virtually all sighted animals, it is important for survival, and it requires interesting computations with…
View article: Contrast normalization affects response time-course of visual interneurons
Contrast normalization affects response time-course of visual interneurons Open
In natural environments, light intensities and visual contrasts vary widely, yet neurons have a limited response range for encoding them. Neurons accomplish that by flexibly adjusting their dynamic range to the statistics of the environmen…
View article: Disynaptic inhibition shapes tuning of OFF-motion detectors in Drosophila
Disynaptic inhibition shapes tuning of OFF-motion detectors in Drosophila Open
The circuitry underlying the detection of visual motion in Drosophila melanogaster is one of the best studied networks in neuroscience. Lately, electron microscopy reconstructions, algorithmic models, and functional studies have proposed a…
View article: Connecting Connectomes to Physiology
Connecting Connectomes to Physiology Open
With the advent of volumetric EM techniques, large connectomic datasets are being created, providing neuroscience researchers with knowledge about the full connectivity of neural circuits under study. This allows for numerical simulation o…
View article: Voltage to Calcium Transformation Enhances Direction Selectivity in<i>Drosophila</i>T4 Neurons
Voltage to Calcium Transformation Enhances Direction Selectivity in<i>Drosophila</i>T4 Neurons Open
An important step in neural information processing is the transformation of membrane voltage into calcium signals leading to transmitter release. However, the effect of voltage to calcium transformation on neural responses to different sen…
View article: Partitioned MPM-FEM Coupling Approach for Advanced Numerical Simulation of Mass-Movement Hazards Impacting Flexible Protective Structures
Partitioned MPM-FEM Coupling Approach for Advanced Numerical Simulation of Mass-Movement Hazards Impacting Flexible Protective Structures Open
The intensity and frequency of natural hazards such as landslides, debris flow, and mud flows have increased significantly over the last years due to climate change and global warming. These catastrophic events are responsible for numerous…
View article: Spatial and temporal control of expression with light-gated LOV-LexA
Spatial and temporal control of expression with light-gated LOV-LexA Open
The ability to drive expression of exogenous genes in different tissues and cell types, under the control of specific enhancers, has been crucial for discovery in biology. While many enhancers drive expression broadly, several genetic tool…
View article: Voltage to Calcium Transformation Enhances Direction Selectivity in <i>Drosophila</i> T4 neurons
Voltage to Calcium Transformation Enhances Direction Selectivity in <i>Drosophila</i> T4 neurons Open
A critical step in neural information processing is the transformation of membrane voltage into calcium signals leading to transmitter release. However, the effect of voltage to calcium transformation on neural responses to different senso…
View article: Anatomical distribution and functional roles of electrical synapses in Drosophila
Anatomical distribution and functional roles of electrical synapses in Drosophila Open
Electrical synapses are present in almost all organisms that have a nervous system. However, their brain-wide expression patterns and the full range of contributions to neural function are unknown in most species. Here, we first provide a …
View article: Spatial and temporal control of expression with light-gated LOV-LexA
Spatial and temporal control of expression with light-gated LOV-LexA Open
The ability to drive expression of exogenous genes in different tissues and cell types, under control of specific enhancers, has been crucial for discovery in biology. While many enhancers drive expression broadly, several genetic tricks w…
View article: Aerial course stabilization is impaired in motion-blind flies
Aerial course stabilization is impaired in motion-blind flies Open
Visual motion detection is among the best understood neuronal computations. As extensively investigated in tethered flies, visual motion signals are assumed to be crucial to detect and counteract involuntary course deviations. During free …
View article: Maximally efficient prediction in the early fly visual system may support evasive flight maneuvers
Maximally efficient prediction in the early fly visual system may support evasive flight maneuvers Open
The visual system must make predictions to compensate for inherent delays in its processing. Yet little is known, mechanistically, about how prediction aids natural behaviors. Here, we show that despite a 20-30ms intrinsic processing delay…
View article: Aerial course stabilization is impaired in motion-blind flies
Aerial course stabilization is impaired in motion-blind flies Open
Visual motion detection is among the best understood neuronal computations. One assumed behavioural role is to detect self-motion and to counteract involuntary course deviations, extensively investigated in tethered walking or flying flies…
View article: Conditional protein tagging methods reveal highly specific subcellular distribution of ion channels in motion-sensing neurons
Conditional protein tagging methods reveal highly specific subcellular distribution of ion channels in motion-sensing neurons Open
Neurotransmitter receptors and ion channels shape the biophysical properties of neurons, from the sign of the response mediated by neurotransmitter receptors to the dynamics shaped by voltage-gated ion channels. Therefore, knowing the loca…