Alexander D. Wright
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View article: Severe hypercalcemia as a result of disseminated Candida krusei infection
Severe hypercalcemia as a result of disseminated Candida krusei infection Open
Candida krusei disseminated infection is a rare complication of protracted neutropenia. Herein, we report a case of a 31-year-old male with relapsed acute myeloid leukemia who developed Candida krusei fungemia with cutaneous, ocular, splen…
View article: Muscle Tension in Generalized Anxiety Disorder During a Stressful Mental Arithmetic Task
Muscle Tension in Generalized Anxiety Disorder During a Stressful Mental Arithmetic Task Open
Introduction: The purpose of this study was to compare muscle tension between individuals with and without generalized anxiety disorder (GAD) during a resting state and a stressful mental arithmetic task. Methods: A total of 95 undergradua…
View article: The Economic Burden of Infective Endocarditis due to Injection Drug Use in Australia: A Single Centre Study—University Hospital Geelong, Barwon Health, Victoria
The Economic Burden of Infective Endocarditis due to Injection Drug Use in Australia: A Single Centre Study—University Hospital Geelong, Barwon Health, Victoria Open
Background. Injection drug use (IDU) is a well-recognized risk factor for infective endocarditis (IE). Associated complications from IDU result in significant morbidity and mortality with substantial cost implications. The aim of this stud…
View article: Repetitive bout of controlled soccer heading does not alter heart rate variability metrics: A preliminary investigation
Repetitive bout of controlled soccer heading does not alter heart rate variability metrics: A preliminary investigation Open
Objectives There is elevated unease regarding how repetitive head impacts, such as those associated with soccer heading, contribute to alterations in brain function. This study examined the extent heart rate variability (HRV) and cardiac b…
View article: Effect of losartan on performance and physiological responses to exercise at high altitude (5035 m)
Effect of losartan on performance and physiological responses to exercise at high altitude (5035 m) Open
Objective Altitude-related and exercise-related elevations in blood pressure (BP) increase the likelihood of developing pulmonary hypertension and high-altitude illness during high-altitude sojourn. This study examined the antihypertensive…
View article: Depressive Symptom Screening in Youth – Using a Community Diabetes Prevention Clinic
Depressive Symptom Screening in Youth – Using a Community Diabetes Prevention Clinic Open
Background: Rates of youth diagnosed with diabetes and prediabetes are increasing and comorbidities like depression warrant strict monitoring to improve patient outcomes. Objective: The aim was to determine if increased depressive symptoms…
View article: An Acute Bout of Soccer Heading Subtly Alters Neurovascular Coupling Metrics
An Acute Bout of Soccer Heading Subtly Alters Neurovascular Coupling Metrics Open
Objective: The current investigation examined how a bout of soccer heading may impact brain function. Design: Semi-randomized crossover cohort. Setting: Controlled soccer heading. Participants: Seven male soccer players (24.1 ± 1.5 years).…
View article: Dynamic cerebral autoregulation across the cardiac cycle during 8 hr of recovery from acute exercise
Dynamic cerebral autoregulation across the cardiac cycle during 8 hr of recovery from acute exercise Open
Current protocols examining cerebral autoregulation (CA) parameters require participants to refrain from exercise for 12-24 hr, however there is sparse objective evidence examining the recovery trajectory of these measures following exerci…
View article: Hypoxia is not the primary mechanism contributing to exercise-induced proteinuria
Hypoxia is not the primary mechanism contributing to exercise-induced proteinuria Open
Introduction Proteinuria increases at altitude and with exercise, potentially as a result of hypoxia. Using urinary alpha-1 acid glycoprotein (α1-AGP) levels as a sensitive marker of proteinuria, we examined the impact of relative hypoxia …
View article: Cross-sectional comparison of spiral versus block integrated curriculums in preparing medical students to diagnose and manage concussions
Cross-sectional comparison of spiral versus block integrated curriculums in preparing medical students to diagnose and manage concussions Open
The findings from this preliminary study suggest the spiral curriculum design, which emphasizes and revisits clinical competencies, promotes a strong understanding and retention of knowledge in highly prevalent clinical conditions such as …
View article: Cerebral Autoregulation Is Disrupted Following a Season of Contact Sports Participation
Cerebral Autoregulation Is Disrupted Following a Season of Contact Sports Participation Open
Repetitive subconcussive head impacts across a season of contact sports participation are associated with a number of deficits in brain function. To date, no research has investigated the effect of such head impact exposure on dynamic cere…
View article: Heading in soccer increases serum neurofilament light protein and SCAT3 symptom metrics
Heading in soccer increases serum neurofilament light protein and SCAT3 symptom metrics Open
Objectives To determine the effect of heading a soccer ball on serum neurofilament light (NF-L) protein, plasma tau protein and symptom metrics including total number of symptoms reported and symptom severity scores on the Standardized Con…
View article: Sport-Related Concussion Alters Indices of Dynamic Cerebral Autoregulation
Sport-Related Concussion Alters Indices of Dynamic Cerebral Autoregulation Open
Sport-related concussion is known to affect a variety of brain functions. However, the impact of this brain injury on cerebral autoregulation (CA) is poorly understood. Thus, the goal of the current study was to determine the acute and cum…
View article: A Prospective Transcranial Doppler Ultrasound-Based Evaluation of the Effects of Repetitive Subconcussive Head Trauma on Neurovascular Coupling Dynamics
A Prospective Transcranial Doppler Ultrasound-Based Evaluation of the Effects of Repetitive Subconcussive Head Trauma on Neurovascular Coupling Dynamics Open
Objective: To determine the effects of repetitive subconcussive head trauma on neurovascular coupling (NVC) responses. Design: Prospective cohort study collected between September 2013 and December 2016. Setting: University laboratory. Par…
View article: A prospective, multidisciplinary approach to understanding sport-related head trauma : novel insights into the effects on myelin and cerebrovascular function
A prospective, multidisciplinary approach to understanding sport-related head trauma : novel insights into the effects on myelin and cerebrovascular function Open
Sport-related concussion occurs at an alarmingly high rate, affecting millions each year. Concern is growing over the effects of repetitive subconcussive head trauma towards the development of long-term neurological deficits. There are cal…
View article: Myelin Water Fraction Is Transiently Reduced after a Single Mild Traumatic Brain Injury – A Prospective Cohort Study in Collegiate Hockey Players
Myelin Water Fraction Is Transiently Reduced after a Single Mild Traumatic Brain Injury – A Prospective Cohort Study in Collegiate Hockey Players Open
Impact-related mild traumatic brain injuries (mTBI) are a major public health concern, and remain as one of the most poorly understood injuries in the field of neuroscience. Currently, the diagnosis and management of such injuries are base…