Alexander Decruyenaere
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View article: Optimal treatment duration in metastatic renal cell carcinoma patients responding to immune checkpoint inhibitors: should we treat beyond two years?
Optimal treatment duration in metastatic renal cell carcinoma patients responding to immune checkpoint inhibitors: should we treat beyond two years? Open
Background and purpose: Optimal treatment duration is unknown in metastatic renal cell carcinoma (mRCC) responding to immune checkpoint inhibitors (ICPIs). Prolonged treatment can lead to late toxicity, burden for day clinics and financial…
View article: Debiasing Synthetic Data Generated by Deep Generative Models
Debiasing Synthetic Data Generated by Deep Generative Models Open
While synthetic data hold great promise for privacy protection, their statistical analysis poses significant challenges that necessitate innovative solutions. The use of deep generative models (DGMs) for synthetic data generation is known …
View article: Real-life experience with sorafenib for advanced and refractory desmoid-type fibromatosis
Real-life experience with sorafenib for advanced and refractory desmoid-type fibromatosis Open
Background: In recent years, there has been a change in the therapeutic landscape of desmoid-type fibromatosis (DF). Watchful waiting is now preferred over initial local treatments such as surgery and radiotherapy. Systemic treatment is co…
View article: Retrospective analysis of multiparametric MRI in Predicting Complete Pathologic Response of Neo-adjuvant Chemotherapy in Bladder Cancer
Retrospective analysis of multiparametric MRI in Predicting Complete Pathologic Response of Neo-adjuvant Chemotherapy in Bladder Cancer Open
Background Muscle invasive bladder cancer (MIBC) treatment combines systemic therapy and radical cystectomy (RC) or local (chemo-)radiotherapy. Response to systemic therapy is an important outcome predictor but is difficult to assess pre-o…
View article: The Real Deal Behind the Artificial Appeal: Inferential Utility of Tabular Synthetic Data
The Real Deal Behind the Artificial Appeal: Inferential Utility of Tabular Synthetic Data Open
Recent advances in generative models facilitate the creation of synthetic data to be made available for research in privacy-sensitive contexts. However, the analysis of synthetic data raises a unique set of methodological challenges. In th…
View article: Epidemiology, causes, evolution and outcome in a single-center cohort of 1116 critically ill patients with hypoxic hepatitis
Epidemiology, causes, evolution and outcome in a single-center cohort of 1116 critically ill patients with hypoxic hepatitis Open
This study surpasses by far the largest cohort of critically ill patients with HH. HH is more common than previously thought with an ICU incidence of 4.0%, and it is associated with a high all-cause mortality of 45.0% at 28 days. The main …