Daniel A. Alexander
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Correction: Innovative approaches in precision radiation oncology: advanced imaging technologies and challenges which shape the future of radiation therapy Open
[This corrects the article DOI: 10.3389/fmed.2025.1686593.].
View article: Innovative approaches in precision radiation oncology: advanced imaging technologies and challenges which shape the future of radiation therapy
Innovative approaches in precision radiation oncology: advanced imaging technologies and challenges which shape the future of radiation therapy Open
Radiation oncology is undergoing a transformative shift toward precision medicine through unprecedented advances in imaging technologies that enable increasingly personalized and adaptive cancer treatment. This comprehensive review synthes…
A novel SGRT system for real‐time optical surface tracking or guidance Open
Purpose Optical 3D surface imaging is a technique that reconstructs a patient's surface without requiring external markers. This study aimed to evaluate the static and dynamic accuracy, as well as performance under varying conditions, incl…
Real-time dosimetry using scintillator technology in external beam radiation therapy (EBRT) Open
Total Skin Electron Therapy (TSET) is a specialized radiotherapy technique used for the treatment of cutaneous T-cell lymphoma and other diffuse skin malignancies. Accurate real-time dosimetry is essential for ensuring precise dose deliver…
Understanding the impact of patient-specific geometries on Cherenkov emission-to-dose relationship during external beam radiation therapy (EBRT) Open
Cherenkov photons generated during External Beam Radiation Therapy (EBRT) provide real-time optical feedback on the radiation field distribution. While Cherenkov emission correlates with radiation dose, patient-specific anatomical variatio…
1H-NMR Lipidomics, Comparing Fatty Acids and Lipids in Cow, Goat, Almond, Cashew, Soy, and Coconut Milk Using NMR and Mass Spectrometry Open
Background/Objectives: Lipids are an important component of human nutrition. Conventional milk is obtained from animals, and dairy milk is consumed by many people worldwide. Recently, milk consumers have been increasingly shifting towards …
Characterization of Cherenkov imaging parameters and positional constraints on an O-ring linear accelerator Open
Objective . With the introduction of Cherenkov imaging technology on the Halcyon O-ring linear accelerator platform, we seek to demonstrate the imaging feasibility and optimize camera placement. Approach . Imaging parameters were probed by…
Evaluation of the cumulative Cherenkov converted dose on TSET patients with multiple Cherenkov cameras Open
Cherenkov images can be used for the quality assurance of dose homogeneity in total skin electron therapy (TSET). For the dose mapping purpose, this study reconstructed the patient model from 3D scans using registration algorithms and comp…
Color-resolved Cherenkov imaging allows for differential signal detection in blood and melanin content Open
Color Cherenkov emission imaging may be used to improve the optical measurement and determination of dose delivered in tissues. Calibration for these factors to minimize the influence of the tissue types and skin tones may be possible usin…
Comparison of surface dose during whole breast radiation therapy on Halcyon and TrueBeam using Cherenkov imaging Open
The emergence of the Halcyon linear accelerator has allowed for increased patient throughput and improved treatment times for common treatment sites in radiation oncology. However, it has been shown that this can lead to increased surface …
View article: Performance comparison of quantitative metrics for analysis of in vivo Cherenkov imaging incident detection during radiotherapy
Performance comparison of quantitative metrics for analysis of in vivo Cherenkov imaging incident detection during radiotherapy Open
Objectives: Examine the responses of multiple image similarity metrics to detect patient positioning errors in radiotherapy observed through Cherenkov imaging, which may be used to optimize automated incident detection. Methods: An anthrop…
3D dose delivery QA using couch and gantry mounted cameras Open
While 2D planar radiation therapy quality assurance techniques suffice for linac verification, a full 3D dosimetry measurement is ideal for robust treatment plan verification. In this study, an optical 3D dose reconstruction technique base…
View article: Retrospective Evaluation of an Always-on Cherenkov Imaging System for Radiotherapy Quality Improvement
Retrospective Evaluation of an Always-on Cherenkov Imaging System for Radiotherapy Quality Improvement Open
Purpose: Cherenkov imaging is now clinically available to track the course of radiation therapy as a treatment verification tool. The aim of this work was to discover the benefits of always-on Cherenkov images as a novel incident detection…
Optimization of in vivo Cherenkov imaging dosimetry via spectral choices for ambient background lights and filtering Open
LP filtering during image acquisition for near-infrared light in tandem with narrow band LED illuminated rooms improves image quality, trading off the loss of red wavelengths for better removal of room light in the image. This spectral fil…
Estimation of diffuse Cherenkov optical emission from external beam radiation build-up in tissue Open
This study explains why the observed Cherenkov emission from tissue is not a strong function of beam energy, despite the known strong correlation between Cherenkov intensity and particle energy in the absence of build-up and scattering eff…
Optical emission‐based phantom to verify coincidence of radiotherapy and imaging isocenters on an MR‐linac Open
Purpose Demonstrate a novel phantom design using a remote camera imaging method capable of concurrently measuring the position of the x‐ray isocenter and the magnetic resonance imaging (MRI) isocenter on an MR‐linac. Methods A conical frus…
Visual Isocenter Position Enhanced Review (VIPER): a Cherenkov imaging‐based solution for MR‐linac daily QA Open
Purpose This study demonstrates a robust Cherenkov imaging‐based solution to MR‐Linac daily QA, including mechanical‐imaging‐radiation isocenter coincidence verification. Methods A fully enclosed acrylic cylindrical phantom was designed to…
Detective quantum efficiency of intensified CMOS cameras for Cherenkov imaging in radiotherapy Open
In this study the metric of detective quantum efficiency (DQE) was applied to Cherenkov imaging systems for the first time, and results were compared for different detector hardware, gain levels and with imaging processing for noise suppre…
Scintillation imaging as a high‐resolution, remote, versatile 2D detection system for MR‐linac quality assurance Open
Purpose To demonstrate the potential benefits of remote camera‐based scintillation imaging for routine quality assurance (QA) measurements for magnetic resonance guided radiotherapy (MRgRT) linear accelerators. Methods A wall‐mounted CMOS …
Assessment of imaging Cherenkov and scintillation signals in head and neck radiotherapy Open
The goal of this study was to test the utility of time-gated optical imaging of head and neck (HN) radiotherapy treatments to measure surface dosimetry in real-time and inform possible interfraction replanning decisions. The benefit of bot…