Alexander Dobrovic
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View article: Demethylating agents drive PARP inhibitor resistance in ovarian carcinomas with BRCA1 gene silencing
Demethylating agents drive PARP inhibitor resistance in ovarian carcinomas with BRCA1 gene silencing Open
DNA methyltransferase 1 inhibitor (DNMT1i) therapy is a promising option for increasing immune response as part of combination cancer therapy. High–grade serous ovarian carcinoma (HGSOC) is a highly aggressive cancer with poor survival out…
View article: BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance
BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance Open
View article: Statin, aspirin and metformin use and risk of hepatocellular carcinoma related outcomes following liver transplantation: A retrospective study
Statin, aspirin and metformin use and risk of hepatocellular carcinoma related outcomes following liver transplantation: A retrospective study Open
BACKGROUND Liver transplantation (LT) is a potentially curative therapy for patients with hepatocellular carcinoma (HCC). HCC-recurrence following LT is associated with reduced survival. There is increasing interest in chemoprophylaxis to …
View article: The role of aberrant DNA methylation in cancer initiation and clinical impacts
The role of aberrant DNA methylation in cancer initiation and clinical impacts Open
Epigenetic alterations, including aberrant DNA methylation, are now recognized as bone fide hallmarks of cancer, which can contribute to cancer initiation, progression, therapy responses and therapy resistance. Methylation of gene promoter…
View article: Graft-derived cfDNA Monitoring in Plasma and Bile During Normothermic Machine Perfusion in Liver Transplantation Is Feasible and a Potential Tool for Assessing Graft Viability
Graft-derived cfDNA Monitoring in Plasma and Bile During Normothermic Machine Perfusion in Liver Transplantation Is Feasible and a Potential Tool for Assessing Graft Viability Open
Background. Ex vivo normothermic machine perfusion (NMP) is an organ preservation technique that enables an extended assessment of graft suitability before liver transplantation (LT). Established monitoring protocols used during NMP vary s…
View article: Graft-Derived Cell-Free DNA Quantification following Liver Transplantation Using Tissue-Specific DNA Methylation and Donor-Specific Genotyping Techniques: An Orthogonal Comparison Study
Graft-Derived Cell-Free DNA Quantification following Liver Transplantation Using Tissue-Specific DNA Methylation and Donor-Specific Genotyping Techniques: An Orthogonal Comparison Study Open
Background: Graft-derived cell-free DNA (gdcfDNA) analysis has shown promise as a non-invasive tool for monitoring organ health following solid organ transplantation. A number of gdcfDNA analysis techniques have been described; however, th…
View article: Identifying primary and secondary MLH1 epimutation carriers displaying low-level constitutional MLH1 methylation using droplet digital PCR and genome-wide DNA methylation profiling of colorectal cancers
Identifying primary and secondary MLH1 epimutation carriers displaying low-level constitutional MLH1 methylation using droplet digital PCR and genome-wide DNA methylation profiling of colorectal cancers Open
View article: Targeting homologous recombination deficiency in uterine leiomyosarcoma
Targeting homologous recombination deficiency in uterine leiomyosarcoma Open
View article: Supplementary Table S4 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer
Supplementary Table S4 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer Open
Supplementary Table S4 from Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer
View article: Supplementary Table S5 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer
Supplementary Table S5 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer Open
Supplementary Table S5 from Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer
View article: Supplementary Table S5 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer
Supplementary Table S5 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer Open
Supplementary Table S5 from Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer
View article: Perspective on this Article from Detection of <i>MGMT</i> Promoter Methylation in Normal Individuals Is Strongly Associated with the T Allele of the rs16906252 <i>MGMT</i> Promoter Single Nucleotide Polymorphism
Perspective on this Article from Detection of <i>MGMT</i> Promoter Methylation in Normal Individuals Is Strongly Associated with the T Allele of the rs16906252 <i>MGMT</i> Promoter Single Nucleotide Polymorphism Open
Perspective on this Article from Detection of MGMT Promoter Methylation in Normal Individuals Is Strongly Associated with the T Allele of the rs16906252 MGMT Promoter Single Nucleotide Polymorphism
View article: Supplementary Table S2 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer
Supplementary Table S2 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer Open
Supplementary Table S2 from Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer
View article: Perspective on this Article from Detection of <i>MGMT</i> Promoter Methylation in Normal Individuals Is Strongly Associated with the T Allele of the rs16906252 <i>MGMT</i> Promoter Single Nucleotide Polymorphism
Perspective on this Article from Detection of <i>MGMT</i> Promoter Methylation in Normal Individuals Is Strongly Associated with the T Allele of the rs16906252 <i>MGMT</i> Promoter Single Nucleotide Polymorphism Open
Perspective on this Article from Detection of MGMT Promoter Methylation in Normal Individuals Is Strongly Associated with the T Allele of the rs16906252 MGMT Promoter Single Nucleotide Polymorphism
View article: Data from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer
Data from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer Open
Women carrying germline mutations in BRCA1 are at a substantially elevated risk of breast cancer and their tumors typically have distinctive morphologic features. We hypothesized that constitutional methylation of the BRCA1 p…
View article: Supplementary Table S2 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer
Supplementary Table S2 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer Open
Supplementary Table S2 from Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer
View article: Supplementary Table S4 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer
Supplementary Table S4 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer Open
Supplementary Table S4 from Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer
View article: Perspective on This Article from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer
Perspective on This Article from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer Open
Perspective on This Article from Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer
View article: Supplementary Table S1 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer
Supplementary Table S1 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer Open
Supplementary Table S1 from Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer
View article: Supplementary Table S3 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer
Supplementary Table S3 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer Open
Supplementary Table S3 from Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer
View article: Data from Detection of <i>MGMT</i> Promoter Methylation in Normal Individuals Is Strongly Associated with the T Allele of the rs16906252 <i>MGMT</i> Promoter Single Nucleotide Polymorphism
Data from Detection of <i>MGMT</i> Promoter Methylation in Normal Individuals Is Strongly Associated with the T Allele of the rs16906252 <i>MGMT</i> Promoter Single Nucleotide Polymorphism Open
Methylation of the CpG island in the MGMT promoter region is a frequent event in several cancer types including colorectal cancer, lung cancer, lymphoma, and glioblastoma. A correlation between methylation and the T allele of the rs…
View article: Perspective on This Article from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer
Perspective on This Article from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer Open
Perspective on This Article from Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer
View article: Supplementary Table S3 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer
Supplementary Table S3 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer Open
Supplementary Table S3 from Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer
View article: Supplementary Table S6 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer
Supplementary Table S6 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer Open
Supplementary Table S6 from Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer
View article: Supplementary Table S1 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer
Supplementary Table S1 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer Open
Supplementary Table S1 from Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer
View article: Supplementary Table S6 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer
Supplementary Table S6 from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer Open
Supplementary Table S6 from Constitutional Methylation of the BRCA1 Promoter Is Specifically Associated with BRCA1 Mutation-Associated Pathology in Early-Onset Breast Cancer
View article: Data from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer
Data from Constitutional Methylation of the <i>BRCA1</i> Promoter Is Specifically Associated with <i>BRCA1</i> Mutation-Associated Pathology in Early-Onset Breast Cancer Open
Women carrying germline mutations in BRCA1 are at a substantially elevated risk of breast cancer and their tumors typically have distinctive morphologic features. We hypothesized that constitutional methylation of the BRCA1 p…
View article: Data from Detection of <i>MGMT</i> Promoter Methylation in Normal Individuals Is Strongly Associated with the T Allele of the rs16906252 <i>MGMT</i> Promoter Single Nucleotide Polymorphism
Data from Detection of <i>MGMT</i> Promoter Methylation in Normal Individuals Is Strongly Associated with the T Allele of the rs16906252 <i>MGMT</i> Promoter Single Nucleotide Polymorphism Open
Methylation of the CpG island in the MGMT promoter region is a frequent event in several cancer types including colorectal cancer, lung cancer, lymphoma, and glioblastoma. A correlation between methylation and the T allele of the rs…
View article: Evaluating treatment response following locoregional therapy for hepatocellular carcinoma: A review of the available serological and radiological tools for assessment
Evaluating treatment response following locoregional therapy for hepatocellular carcinoma: A review of the available serological and radiological tools for assessment Open
Hepatocellular carcinoma (HCC) is an aggressive primary malignancy of the liver and is the third most common cause of cancer‐related global mortality. There has been a steady increase in treatment options for HCC in recent years, including…
View article: Supplementary Figure 1 from <i>BRAF/NRAS</i> Wild-Type Melanomas Have a High Mutation Load Correlating with Histologic and Molecular Signatures of UV Damage
Supplementary Figure 1 from <i>BRAF/NRAS</i> Wild-Type Melanomas Have a High Mutation Load Correlating with Histologic and Molecular Signatures of UV Damage Open
Supplementary Figure 1 - PDF file 91K, Schematic diagram of experimental procedure and bioinformatic analysis