Alexander Floru
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A drug that induces the microRNA miR-124 enables differentiation of retinoic acid–resistant neuroblastoma cells Open
Tumor cell heterogeneity in neuroblastoma, a pediatric cancer arising from neural crest–derived progenitor cells, presents clinical challenges. Unlike adrenergic (ADRN) neuroblastoma cells, neuroblastoma cells with a mesenchymal (MES) iden…
Novel miRNA-inducing drugs enable differentiation of retinoic acid-resistant neuroblastoma cells Open
Tumor cell heterogeneity in neuroblastoma, a pediatric cancer arising from neural crest-derived progenitor cells, poses a significant clinical challenge. In particular, unlike adrenergic (ADRN) neuroblastoma cells, mesenchymal (MES) cells …
View article: CKLF instigates a “cold” microenvironment to promote MYCN-mediated tumor aggressiveness
CKLF instigates a “cold” microenvironment to promote MYCN-mediated tumor aggressiveness Open
Solid tumors, especially those with aberrant MYCN activation, often harbor an immunosuppressive microenvironment to fuel malignant growth and trigger treatment resistance. Despite this knowledge, there are no effective strategies to tackle…
T <sub>reg</sub> cells drive MYCN-mediated immunosuppression and tumor aggressiveness in high-risk neuroblastoma Open
Solid tumors, especially those with aberrant MYCN activation, harbor an immunosuppressive microenvironment to fuel malignant growth and trigger treatment resistance 1,2 , yet the underlying mechanisms are elusive and effective strategies t…