Explanipedia

Bacterial Infections Shape Cardiac Macrophages’ Response to Ischemia Open

Simon Geißen, Alexander Hof, Emmanuel Philip, Elena Wagner, Charlotte Schreiber , et al. · 2025

BACKGROUND: Patients with bacterial infections are at increased risk for subsequent cardiovascular events. Whether infections’ effects on innate immune cells within the cardiovascular system influence subsequent pathologies remains unclear…

Myeloperoxidase impacts vascular function by altering perivascular adipocytes’ secretome and phenotype in obesity Open

Alexander Hof, Max Landerer, Philipp Peitsmeyer, Raphael Herzog, Jens Alber , et al. · 2025

Obesity, a main driver of cardiovascular morbidity, contributes to endothelial dysfunction and inflammation in adipose tissues. Perivascular adipose tissue (PVAT) surrounds arteries and influences vascular function. In obesity, immune cell…

Inhibition of myeloperoxidase to treat left ventricular dysfunction in non‐ischaemic cardiomyopathy Open

Simon Geißen, Simon Braumann, Joana Adler, Felix Sebastian Nettersheim, Dennis Mehrkens , et al. · 2024

Aims Non‐ischaemic cardiomyopathy (NICMP), an incurable disease terminating in systolic heart failure (heart failure with reduced ejection fraction [HFrEF]), causes immune activation, however anti‐inflammatory treatment strategies so far h…

Myeloperoxidase induces monocyte migration and activation after acute myocardial infarction Open

Vera B. M. Peters, Friederike Matheis, I Erdmann, Harshal Nemade, David Muders , et al. · 2024

Introduction Myocardial infarction (MI) is a significant contributor to morbidity and mortality worldwide. Many individuals who survive the acute event continue to experience heart failure (HF), with inflammatory and healing processes post…

Vascular Ultrasound for In Vivo Assessment of Arterial Pathologies in a Murine Model of Atherosclerosis and Aortic Aneurysm Open

Alexander Hof, Henning Guthoff, Maysam Ahdab, Max Landerer, Jasper Schäkel , et al. · 2023

Vascular diseases like atherosclerosis and abdominal aortic aneurysm (AAA) are common pathologies in the western world, promoting various potentially fatal conditions. Here, we evaluate high-resolution (HR) ultrasound in mouse models of at…

Myeloperoxidase is a critical mediator of anthracycline-induced cardiomyopathy Open

Felix Sebastian Nettersheim, Johannes David Schlüter, Wiebke Kreuzberg, Dennis Mehrkens, Simon Grimm , et al. · 2023

Feasibility and outcome of third-generation transcatheter aortic valve implantation in patients with extra-large aortic annulus Open

Alexander Hof, Hendrik Wienemann, Verena Veulemans, Sebastian Ludwig, Tanja K. Rudolph , et al. · 2023

Protective Effects of Therapeutic Neutrophil Depletion and Myeloperoxidase Inhibition on Left Ventricular Function and Remodeling in Myocardial Infarction Open

Henning Guthoff, Alexander Hof, Anna Klinke, Martina Maaß, Jürgen Konradi , et al. · 2022

Myocardial infarction (MI) is a leading cause of morbidity and mortality worldwide. Improved survival has led to an increasing incidence of ischemic cardiomyopathy, making it a major reason for hospitalization in the western world. The inf…

Vascular ultrasound for<i>in vivo</i>assessment of arterial pathologies in a murine model of atherosclerosis and aortic aneurysm Open

Alexander Hof, Henning Guthoff, Maysam Ahdab, Max Landerer, Jasper Schäkel , et al. · 2022

Background Vascular diseases like atherosclerosis or aortic aneurysms are common pathologies in the western world, promoting various, potentially fatal conditions. Hence, a plethora of animal models have been developed to investigate under…

Transcatheter aortic valve implantation with different self-expanding devices—a propensity score-matched multicenter comparison Open

Hendrik Wienemann, Alexander Hof, Sebastian Ludwig, Verena Veulemans, Alexander Sedaghat , et al. · 2022

In this multicenter study, TAVI with the ACURATE neo, Evolut R, or Evolut PRO was feasible and safe. The rate of relevant PVR was more frequent after the ACURATE neo implantation, with, however, lower rates of PPI. Two-year survival was ma…

Myeloperoxidase is a Critical Mediator of Anthracycline-induced Cardiomyopathy Open

Felix Sebastian Nettersheim, Johannes David Schlüter, Wiebke Kreuzberg, Simon Geißen, Dennis Mehrkens , et al. · 2022

Cardiotoxicity is a major complication of anthracycline therapy that negatively impacts prognosis. Effective pharmacotherapies for prevention of anthracycline-induced cardiomyopathy (AICM) are currently lacking. Increased plasma levels of …

Inhibition of myeloperoxidase attenuates thoracic aortic aneurysm formation in Marfan disease Open

Dennis Mehrkens, Felix Sebastian Nettersheim, Felix Ballmann, Jil Bastigkeit, Alexander Brückner , et al. · 2022

Marfan syndrome (MFS) is the most prevalent inherited connective tissue disorder, still remains uncurable, and is characterized by high mortality at early age driven by dissection and rupture of thoracic aortic aneurysms. MFS is caused by …

Inhibition of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosis Open

Harshal Nemade, Dennis Mehrkens, Hannah Sophia Lottermoser, Zeynep Ece Yilmaz, Patrick Schelemei , et al. · 2022

Background Receptor-interacting serine/threonine-protein kinase 1 and 3 (RIPK1 and RIPK3) dependent cell death has been identified as a crucial mediator of abdominal aortic aneurysm (AAA) development. RIPK3 mediates phosphorylation of Mixe…

Treatment of left ventricular dysfunction in dilated cardiomyopathy with a myeloperoxidase inhibitor Open

Simon Geißen, Simon Braumann, Joana Adler, Felix Sebastian Nettersheim, Dennis Mehrkens , et al. · 2022

Dilated cardiomyopathy (DCM), an incurable disease of the cardiomyocyte terminating in systolic heart failure (HFrEF), is prevalent, causes hospitalization and is associated with increased mortality. Despite evidence of immune activation i…

Myeloid leukocytes’ diverse effects on cardiovascular and systemic inflammation in chronic kidney disease Open

Alexander Hof, Simon Geißen, Kezia Singgih, Martin Mollenhauer, Holger Winkels , et al. · 2022

Feasibility and Comparison of Resting Full-Cycle Ratio and Computed Tomography Fractional Flow Reserve in Patients with Severe Aortic Valve Stenosis Open

Hendrik Wienemann, Marcel C. Langenbach, Victor Mauri, Maryam Banazadeh, Konstantin Klein , et al. · 2022

Background: Computed tomography derived Fractional Flow Reserve (CT-FFR) has been shown to decrease the referral rate for invasive coronary angiography (ICA). The purpose of the study was to evaluate the diagnostic performance of CT-FFR co…

Stamp2 Protects From Maladaptive Structural Remodeling and Systolic Dysfunction in Post-Ischemic Hearts by Attenuating Neutrophil Activation Open

Martin Mollenhauer, Senai Bokredenghel, Simon Geißen, Anna Klinke, Tobias Morstadt , et al. · 2021

The six-transmembrane protein of prostate 2 (Stamp2) acts as an anti-inflammatory protein in macrophages by protecting from overt inflammatory signaling and Stamp2 deficiency accelerates atherosclerosis in mice. Herein, we describe an unex…

Nitro-Oleic Acid (NO2-OA) Improves Systolic Function in Dilated Cardiomyopathy by Attenuating Myocardial Fibrosis Open

Simon Braumann, Wibke Schumacher, Nam Gyu Im, Felix Sebastian Nettersheim, Dennis Mehrkens , et al. · 2021

Nitro-oleic acid (NO2-OA), a nitric oxide (NO)- and nitrite (NO2−)-derived electrophilic fatty acid metabolite, displays anti-inflammatory and anti-fibrotic signaling actions and therapeutic benefit in murine models of ischemia-reperfusion…

Innominate vs. Axillary Artery Cannulation in Aortic Surgery: a Systematic Review and Meta- Analysis Open

Amer Harky, Jeffrey Shi Kai Chan, Christiana Bithas, Alexander Hof, Monira Sharif , et al. · 2019

There is no superiority of axillary over innominate artery cannulation in thoracic aortic surgery in terms of perioperative outcomes; however, as the studies were limited, larger scale comparative studies are required to provide a solid ev…

Innominate vs. Axillary Artery Cannulation in Aortic Surgery: a Systematic Review and Meta-Analysis Open

Amer Harky, Jeffrey SK Chan, Christiana Bithas, Alexander Hof, Monira Sharif , et al. · 2019

Objective: To investigate whether axillary artery cannulation has supremacy over innominate artery cannulation in thoracic aortic surgery. Methods: A comprehensive search was undertaken among the four major databases (PubMed, Excerpta Medi…

Enzymes of the purinergic signaling system exhibit diverse effects on the degeneration of valvular interstitial cells in a 3‐D microenvironment Open

Andreas Weber, Mareike Barth, Jessica Isabel Selig, Silja Raschke, Konstantinos Dakaras , et al. · 2018

Calcific aortic valve disease is an active disease process with lipoprotein deposition, chronic in‐flammation, and progressive leaflet degeneration. Expression of ectonucleotidases, a group of membrane‐bound enzymes that regulate the metab…

Challenges in developing a reseeded, tissue-engineered aortic valve prosthesis Open

Alexander Hof, Silja Raschke, Karina Baier, Laura Nehrenheim, Jessica Isabel Selig , et al. · 2016

A comparison of different techniques for increasing interstitial repopulation of detergent dECM revealed that an additional limited trypsin treatment was most effective. Nevertheless, a complete interstitial repopulation of decellularized …

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