Alexander Horke
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View article: Transcriptional and functional effects of mavacamten in multiple porcine and human models with hypertrophic cardiomyopathy
Transcriptional and functional effects of mavacamten in multiple porcine and human models with hypertrophic cardiomyopathy Open
Background and Purpose Mavacamten (MAVA) is a novel small molecule inhibitor of cardiac myosin, mitigating cardiomyocyte hypercontractility in patients with hypertrophic obstructive cardiomyopathy (HOCM). Despite its recent approval for cl…
View article: Pre-bypass ultrafiltration reduces cytokine burden of blood prime in pediatric cardiac surgery
Pre-bypass ultrafiltration reduces cytokine burden of blood prime in pediatric cardiac surgery Open
View article: A rule-based clinical decision support system for detection of acute kidney injury after pediatric cardiac surgery
A rule-based clinical decision support system for detection of acute kidney injury after pediatric cardiac surgery Open
We demonstrated that a CDSS is able to perform a complex AKI detection and staging process, including 11 criteria across three stages. For accurate automated AKI detection, standardized machine-readable data of high data quality are requir…
View article: Pre-Bypass Ultrafiltration reduces Cytokine Burden of Blood Prime in Pediatric Cardiac Surgery
Pre-Bypass Ultrafiltration reduces Cytokine Burden of Blood Prime in Pediatric Cardiac Surgery Open
Allogeneic red blood cells (RBCs) are commonly used for cardiopulmonary bypass (CPB) circuit priming in congenital heart surgery. While convection-based pre-bypass ultrafiltration (PBUF) corrects acid-base, electrolyte, and metabolite imba…
View article: Radiation exposure during cardiac interventions in CHD: German Registry 2012-2020
Radiation exposure during cardiac interventions in CHD: German Registry 2012-2020 Open
Background: Since patients with congenital heart defects (CHD) frequently require life-long medical care and repeat invasive treatment, radiation exposure during interventional procedures is a relevant issue concerning potential radiation …
View article: Early-life thymectomy leads to an increase of granzyme-producing γδ T cells in children with congenital heart disease
Early-life thymectomy leads to an increase of granzyme-producing γδ T cells in children with congenital heart disease Open
Congenital heart disease (CHD) is the most common birth defect in newborns, often requiring cardiac surgery with concomitant thymectomy that is known to increase disease susceptibility later in life. Studies of γδ T cells, which are one of…
View article: Authors’ response to ‘enhancing decellularized aortic allografts for paediatric aortic valve replacement: insights and future directions’
Authors’ response to ‘enhancing decellularized aortic allografts for paediatric aortic valve replacement: insights and future directions’ Open
View article: Authors’ response to the invited commentary on decellularized aortic allografts for paediatric aortic valve replacement
Authors’ response to the invited commentary on decellularized aortic allografts for paediatric aortic valve replacement Open
View article: Five-year results from a prospective, single-arm European trial on decellularized allografts for aortic valve replacement—the ARISE Study and ARISE Registry Data
Five-year results from a prospective, single-arm European trial on decellularized allografts for aortic valve replacement—the ARISE Study and ARISE Registry Data Open
OBJECTIVES Decellularized aortic homografts (DAH) were introduced as a new option for aortic valve replacement for young patients. METHODS A prospective, EU-funded, single-arm, multicentre study in 8 centres evaluating non-cryopreserved DA…
View article: Paediatric aortic valve replacement using decellularized allografts: a multicentre update following 143 implantations and five-year mean follow-up
Paediatric aortic valve replacement using decellularized allografts: a multicentre update following 143 implantations and five-year mean follow-up Open
OBJECTIVES Decellularized aortic homografts (DAH) were introduced in 2008 as a further option for paediatric aortic valve replacement (AVR). METHODS Prospective, multicentre follow-up of all paediatric patients receiving DAH for AVR in 8 E…
View article: German Registry for Cardiac Operations and Interventions in Congenital Heart Disease: Annual Report 2022
German Registry for Cardiac Operations and Interventions in Congenital Heart Disease: Annual Report 2022 Open
Background The German Registry for Cardiac Operations and Interventions in Patients with Congenital Heart Disease is a voluntary registry initiated by the German Society for Thoracic and Cardiovascular Surgery and the German Society for Pe…
View article: Early-life thymectomy enhances persistence of fetal-derived γδ T cells in children with congenital heart disease
Early-life thymectomy enhances persistence of fetal-derived γδ T cells in children with congenital heart disease Open
Congenital heart disease (CHD) is the most common birth defect in newborns, often requiring surgical correction with thymectomy that is known to affect the T-cell pool and subsequent disease susceptibility. Studies of γδ T cells, which dev…
View article: Möglichkeiten des Aortenklappenersatzes beim jungen Erwachsenen: dezellularisierte menschliche Spenderklappen
Möglichkeiten des Aortenklappenersatzes beim jungen Erwachsenen: dezellularisierte menschliche Spenderklappen Open
Zusammenfassung Hintergrund Die Wahl des Aortenklappenersatzverfahrens beim jungen erwachsenen Patienten hat viele verschiedene Aspekte zu berücksichtigen. Fragestellung Vergleich der Ergebnisse der Ross-Operation, des mechanischen und bio…
View article: Bilateral lung transplantation for pediatric pulmonary arterial hypertension: perioperative management and one-year follow-up
Bilateral lung transplantation for pediatric pulmonary arterial hypertension: perioperative management and one-year follow-up Open
Background Bilateral lung transplantation (LuTx) remains the only established treatment for children with end-stage pulmonary arterial hypertension (PAH). Although PAH is the second most common indication for LuTx, little is known about op…
View article: Recovery of Biventricular Function After Catheter Intervention or Surgery for Neonatal Coarctation of the Aorta
Recovery of Biventricular Function After Catheter Intervention or Surgery for Neonatal Coarctation of the Aorta Open
View article: Matched comparison of decellularized homografts and bovine jugular vein conduits for pulmonary valve replacement in congenital heart disease
Matched comparison of decellularized homografts and bovine jugular vein conduits for pulmonary valve replacement in congenital heart disease Open
View article: Simultaneous Aortic and Pulmonary Valve Replacement in Repaired Congenital Heart Disease
Simultaneous Aortic and Pulmonary Valve Replacement in Repaired Congenital Heart Disease Open
Objectives Patients with congenital heart disease frequently require surgical or percutaneous interventional valve replacement after initial congenital heart defect (CHD) repair. In some of these patients, simultaneous replacement of both …
View article: Surgical management of large tracheoesophageal fistula in infants after button battery ingestion
Surgical management of large tracheoesophageal fistula in infants after button battery ingestion Open
OBJECTIVES In recent years, an increase in severe and even fatal outcomes related to oesophageal or airway button battery (BB) ingestion by infants and small children has been reported. Extensive tissue necrosis caused by lodged BB can lea…
View article: German Registry for Cardiac Operations and Interventions in Patients with Congenital Heart Disease: Report 2021 and 9 Years' Longitudinal Observations on Fallot and Coarctation Patients
German Registry for Cardiac Operations and Interventions in Patients with Congenital Heart Disease: Report 2021 and 9 Years' Longitudinal Observations on Fallot and Coarctation Patients Open
Background The annual report of the German Quality Assurance of Congenital Heart Disease displays a broad overview on outcome of interventional and surgical treatment with respect to patient's age and risk categorization. Particular featur…
View article: Serial assessment of early antibody binding to decellularized valved allografts
Serial assessment of early antibody binding to decellularized valved allografts Open
Objectives Decellularized homograft valves (DHV) appear to elicit an immune response despite efficient donor cell removal. Materials and methods A semiquantitative Dot-Blot analysis for preformed and new recipient antibodies was carried ou…
View article: Incidence and characteristics of errors detected by a short team briefing in pediatric anesthesia
Incidence and characteristics of errors detected by a short team briefing in pediatric anesthesia Open
Background In our institution, a modified WHO surgical safety checklist was implemented more than ten years ago. In retrospect, we noticed that pediatric anesthesia was underrepresented in our surgical safety checklist modification. Theref…
View article: 5-Year results from the prospective European multi-centre study on decellularized homografts for pulmonary valve replacement ESPOIR Trial and ESPOIR Registry data
5-Year results from the prospective European multi-centre study on decellularized homografts for pulmonary valve replacement ESPOIR Trial and ESPOIR Registry data Open
OBJECTIVES Early results from the prospective ESPOIR Trial have indicated excellent results for pulmonary valve replacement using decellularized pulmonary homografts (DPH). METHODS A 5-year analysis of ESPOIR Trial patients was performed t…
View article: 4D-flow cardiac magnetic resonance imaging after aortic root replacement with long-valved decellularized aortic homografts: comparison to valve-sparing aortic root replacement and healthy controls
4D-flow cardiac magnetic resonance imaging after aortic root replacement with long-valved decellularized aortic homografts: comparison to valve-sparing aortic root replacement and healthy controls Open
OBJECTIVES Long-valved decellularized aortic homografts (DAH) may be used in young patients to treat aortic valve disease associated with aortic root dilatation, thereby eliminating the need for prosthetic material and anticoagulation. MET…
View article: Idiopathic Aneurysm of the Aortic Arch in an Infant
Idiopathic Aneurysm of the Aortic Arch in an Infant Open
Congenital aortic aneurysms are rare disorders, usually associated with genetic aortic syndromes. Here, we describe the case of an idiopathic aortic arch aneurysm which had been diagnosed prenatally by fetal echocardiography. The diagnosis…
View article: Pediatric urgent heart transplantation with age or weight mismatched donors: Reducing waiting time by enlarging donor criteria
Pediatric urgent heart transplantation with age or weight mismatched donors: Reducing waiting time by enlarging donor criteria Open
Postoperative course and early follow-up after mHTX were comparable to sHTX. In urgent clinical situations, extended donor criteria may be considered an additional option for pediatric heart transplantation.
View article: Pulmonary valve prostheses: patient’s lifetime procedure load and durability. Evaluation of the German National Register for Congenital Heart Defects
Pulmonary valve prostheses: patient’s lifetime procedure load and durability. Evaluation of the German National Register for Congenital Heart Defects Open
OBJECTIVES We evaluated 4384 procedures performed between 1957 and 2018, collected in the National Register for Congenital Heart Defects, conducted on 997 patients with 1823 pulmonary valve replacements (PVRs), including 226 implanted via …
View article: Valve-sparing aortic root replacement in adult patients with congenital heart disease
Valve-sparing aortic root replacement in adult patients with congenital heart disease Open
OBJECTIVES Aortic root dilatation is frequently observed in patients with congenital heart defects (CHD), but has received little attention in terms of developing a best practice approach for treatment. In this study, we analysed our exper…
View article: German Registry for Cardiac Operations and Interventions in Patients with Congenital Heart Disease: Report 2020—Comprehensive Data from 6 Years of Experience
German Registry for Cardiac Operations and Interventions in Patients with Congenital Heart Disease: Report 2020—Comprehensive Data from 6 Years of Experience Open
Background Based on a quality assurance initiative of the German Society for Thoracic and Cardiovascular Surgery (DGTHG) and the German Society for Pediatric Cardiology and Congenital Heart Defects (DGPK), a voluntary registry was founded …
View article: Prevention of postoperative bleeding after complex pediatric cardiac surgery by early administration of fibrinogen, prothrombin complex and platelets: a prospective observational study
Prevention of postoperative bleeding after complex pediatric cardiac surgery by early administration of fibrinogen, prothrombin complex and platelets: a prospective observational study Open
Background Postoperative bleeding is a major problem in children undergoing complex pediatric cardiac surgery. The primary aim of this prospective observational study was to evaluate the effect of an institutional approach consisting of ea…
View article: Residual immune response towards decellularized homografts may be highly individual
Residual immune response towards decellularized homografts may be highly individual Open
OBJECTIVES Decellularized homograft valves (DHVs) have shown promising clinical results, particularly in the treatment of congenital heart disease. However, DHV appears to elicit an immune response in a subset of young patients, indicated …