Alexander Humberg
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View article: Predictive value of increased C-reactive protein levels in preterm infants on respiratory function at five to six years of age: a cohort study
Predictive value of increased C-reactive protein levels in preterm infants on respiratory function at five to six years of age: a cohort study Open
Objective The multifactorial pathophysiology of chronic lung disease in very low birthweight infants (VLBWI) includes inflammatory driven trauma of the lungs. Study Design Multicentre observational study to evaluate the predictive value of…
View article: Study protocol: neonatal colonisation and infection with <i>Ureaplasma</i> in very immature preterm infants born <29 weeks of gestation (NEO-CONSCIOUS) – a prospective multicentre study assessing early life colonisation rates and potentially associated adverse outcomes
Study protocol: neonatal colonisation and infection with <i>Ureaplasma</i> in very immature preterm infants born <29 weeks of gestation (NEO-CONSCIOUS) – a prospective multicentre study assessing early life colonisation rates and potentially associated adverse outcomes Open
Introduction Preterm infants, particularly those born before 29 weeks of gestation, are at increased risk of developing bronchopulmonary dysplasia (BPD) and other complications of prematurity. Substantial evidence suggests that respiratory…
View article: An open abdomen is not a contraindication for ECMO in children with cancer
An open abdomen is not a contraindication for ECMO in children with cancer Open
View article: Necrolytic migratory erythema following prolonged continuous subcutaneous dasiglucagon administration: a rare dermatologic adverse event
Necrolytic migratory erythema following prolonged continuous subcutaneous dasiglucagon administration: a rare dermatologic adverse event Open
Summary Clinical management of congenital hyperinsulinism (CHI) remains a significant challenge due to its complex pathophysiology and the limitations of available therapies. Dasiglucagon, a synthetic glucagon analog, represents a novel ap…
View article: Influenza Immunization in Very-Low-Birth-Weight Infants: Epidemiology and Long-Term Outcomes
Influenza Immunization in Very-Low-Birth-Weight Infants: Epidemiology and Long-Term Outcomes Open
Background: Very-low-birth-weight infants (VLBWIs; birth weight < 1500 g) are at an increased risk of complicated influenza infection, which frequently includes pneumonia, encephalitis or even death. Data on influenza immunization and its …
View article: Infants < 90 days of age with late-onset sepsis display disturbances of the microbiome-immunity interplay
Infants < 90 days of age with late-onset sepsis display disturbances of the microbiome-immunity interplay Open
View article: First postnatal lactate blood levels on day 1 and outcome of preterm infants with gestational age <29 weeks
First postnatal lactate blood levels on day 1 and outcome of preterm infants with gestational age <29 weeks Open
Background Serum lactate levels are used as biomarkers for perinatal asphyxia, while their value for outcome prediction in preterm infants is uncertain. It was the aim of this observational study to determine the association of the first p…
View article: Neonatal Sepsis Episodes and Retinopathy of Prematurity in Very Preterm Infants
Neonatal Sepsis Episodes and Retinopathy of Prematurity in Very Preterm Infants Open
Importance Retinopathy of prematurity (ROP) is a major morbidity of preterm infants causing visual impairment, including blindness, for which timely treatment is vital and prevention is key. Increasing evidence suggests that exposure to ne…
View article: Antimicrobial Peptides (AMPs) and the Microbiome in Preterm Infants: Consequences and Opportunities for Future Therapeutics
Antimicrobial Peptides (AMPs) and the Microbiome in Preterm Infants: Consequences and Opportunities for Future Therapeutics Open
Antimicrobial peptides (AMPs) are crucial components of the innate immune system in various organisms, including humans. Beyond their direct antimicrobial effects, AMPs play essential roles in various physiological processes. They induce a…
View article: Respiratory Syncytial Virus Prophylaxis With Palivizumab Is Not Associated With Improved Lung Function in Infants of Very Low Birth Weight at Early School Age
Respiratory Syncytial Virus Prophylaxis With Palivizumab Is Not Associated With Improved Lung Function in Infants of Very Low Birth Weight at Early School Age Open
BackgroundPrematurity and infection with respiratory syncytial virus (RSV) are major risk factors for impaired lung function beyond the neonatal period.Research QuestionWhat are the long-term effects of palivizumab immunoprophylaxis in the…
View article: Antimicrobial skin peptides in premature infants: Comparison with term infants and impact of perinatal factors
Antimicrobial skin peptides in premature infants: Comparison with term infants and impact of perinatal factors Open
Introduction Preterm infants have an immature epidermis barrier function that may lead to an increased permeability to pathogens. On the surface of the human skin, antimicrobial peptides (AMPs) are important molecules of the innate immune …
View article: Supplementary Material for: Indomethacin Prophylaxis Is Associated with Reduced Risk of Intraventricular Hemorrhage in Extremely Preterm Infants Born in the Context of Amniotic Infection Syndrome
Supplementary Material for: Indomethacin Prophylaxis Is Associated with Reduced Risk of Intraventricular Hemorrhage in Extremely Preterm Infants Born in the Context of Amniotic Infection Syndrome Open
Background: Amniotic infection syndrome (AIS) with perinatal inflammation may increase the susceptibility to intraventricular hemorrhage (IVH) in preterm infants. Given its anti-inflammatory and ductus arteriosus constricting…
View article: Association of Administration of Surfactant Using Less Invasive Methods With Outcomes in Extremely Preterm Infants Less Than 27 Weeks of Gestation
Association of Administration of Surfactant Using Less Invasive Methods With Outcomes in Extremely Preterm Infants Less Than 27 Weeks of Gestation Open
Importance The inclusion of less invasive surfactant administration (LISA) in the care of preterm infants has been found to be beneficial for respiratory outcomes. Recently, the OPTIMIST trial found higher mortality rates in the subgroup o…
View article: A Timely Administration of Antenatal Steroids Is Highly Protective Against Intraventricular Hemorrhage: An Observational Multicenter Cohort Study of Very Low Birth Weight Infants
A Timely Administration of Antenatal Steroids Is Highly Protective Against Intraventricular Hemorrhage: An Observational Multicenter Cohort Study of Very Low Birth Weight Infants Open
Aim The aim of the study is to evaluate the influence of the timing of antenatal steroids (ANSs) on neonatal outcome of very low birth weight infants (VLBWI) born before 30 weeks of gestation in the German Neonatal Network. Methods The Ger…
View article: Supplementary Material for: Recurrent Late-Onset Sepsis in Extremely Low Birth Weight Infants Is Associated with Motor Deficits in Early School Age
Supplementary Material for: Recurrent Late-Onset Sepsis in Extremely Low Birth Weight Infants Is Associated with Motor Deficits in Early School Age Open
Introduction: Sepsis is regarded as a risk factor for brain injury in preterm infants. We herein hypothesize that extremely low birth weight infants (ELBWI, birth weight <1,000 g) having survived recurrent blood culture-prove…
View article: Infants Younger Than 90 Days Admitted for Late-Onset Sepsis Display a Reduced Abundance of Regulatory T Cells
Infants Younger Than 90 Days Admitted for Late-Onset Sepsis Display a Reduced Abundance of Regulatory T Cells Open
Objective To provide epidemiological data of infants < 90 days of age with suspected late-onset sepsis (LOS) and evaluate distinct immunological specificities. We hypothesized that previously healthy infants < 3 months of age with se…
View article: Five Year Follow Up of Extremely Low Gestational Age Infants after Timely or Delayed Administration of Routine Vaccinations
Five Year Follow Up of Extremely Low Gestational Age Infants after Timely or Delayed Administration of Routine Vaccinations Open
This study is aimed at detecting the rate of untimely immunization in a large cohort of extremely low gestational age neonates (ELGANs) of the German Neonatal Network (GNN) and at addressing risk factors for delayed vaccination and associa…
View article: Neonatal Outcome After Preeclampsia and HELLP Syndrome: A Population-Based Cohort Study in Germany
Neonatal Outcome After Preeclampsia and HELLP Syndrome: A Population-Based Cohort Study in Germany Open
Aim: To analyze short term outcomes of very low birth weight infants (VLBWI) born preterm after maternal preeclampsia and HELLP syndrome within the German Neonatal Network. Methods: The German Neonatal Network is a large popu…
View article: Sepsis related mortality of extremely low gestational age newborns after the introduction of colonization screening for multi-drug resistant organisms
Sepsis related mortality of extremely low gestational age newborns after the introduction of colonization screening for multi-drug resistant organisms Open
View article: Preterm birth and sustained inflammation: consequences for the neonate
Preterm birth and sustained inflammation: consequences for the neonate Open
View article: Genetic predisposition for vitamin D deficiency is not associated with adverse outcome of very low birth weight infants: A cohort study from the German Neonatal Network
Genetic predisposition for vitamin D deficiency is not associated with adverse outcome of very low birth weight infants: A cohort study from the German Neonatal Network Open
Low genetic vitamin D level estimates could not be shown to be associated with previously described adverse outcome in preterm infants.
View article: Lactobacillus Acidophilus/Bifidobacterium Infantis Probiotics Are Beneficial to Extremely Low Gestational Age Infants Fed Human Milk
Lactobacillus Acidophilus/Bifidobacterium Infantis Probiotics Are Beneficial to Extremely Low Gestational Age Infants Fed Human Milk Open
Objective: To evaluate the nutrition-related effects of prophylactic Lactobacillus acidophilus/Bifidobacterium infantis probiotics on the outcomes of preterm infants <29 weeks of gestation that receive human milk and/or formula nutrition. …
View article: Surgical necrotizing enterocolitis but not spontaneous intestinal perforation is associated with adverse neurological outcome at school age
Surgical necrotizing enterocolitis but not spontaneous intestinal perforation is associated with adverse neurological outcome at school age Open
View article: Less invasive surfactant administration and complications of preterm birth
Less invasive surfactant administration and complications of preterm birth Open
View article: The association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants
The association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants Open
In a large cohort of VLBWI MBL2 deficiency had no major impact on infection risk unless children were born between 32 0/7 and 36 6/7 weeks of gestation.
View article: Intermediate Follow-up of Pediatric Patients With Hemolytic Uremic Syndrome During the 2011 Outbreak Caused by E. coli O104:H4
Intermediate Follow-up of Pediatric Patients With Hemolytic Uremic Syndrome During the 2011 Outbreak Caused by E. coli O104:H4 Open
The overall outcome of pediatric patients after HUS due to E. coli O104:H4 was equivalent to previous reports on HUS due to other types of Shiga toxin-producing E. coli (STEC). Regular follow-up visits in patients are recommended after STE…
View article: Preterm Birth during Influenza Season Is Associated with Adverse Outcome in Very Low Birth Weight Infants
Preterm Birth during Influenza Season Is Associated with Adverse Outcome in Very Low Birth Weight Infants Open
Our observational data indicate that preterm birth during influenza season is associated with PVL and sepsis. These are novel aspects that deserve further investigations to address underlying causes and to include virus surveillance.
View article: Endotracheale Intubation von Kindern
Endotracheale Intubation von Kindern Open
Procedure of intubation of children is different to intubation in adults and requires specific considerations. Before intubation management of difficult airway problems should be anticipated. Risk of developing hypoxia is common in childre…