Alexander J. Lepak
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View article: Telehealth: The Way for Efficient, Comprehensive, and Equitable Antimicrobial Stewardship in the US Healthcare System
Telehealth: The Way for Efficient, Comprehensive, and Equitable Antimicrobial Stewardship in the US Healthcare System Open
Rural and critical access hospitals serve 15% of the United States population and utilize antibiotics at similar rates and spectrum as larger urban hospitals, making them a priority for antimicrobial stewardship. However, barriers such as …
View article: Effectiveness of imipenem-relebactam for multidrug-resistant <i>Pseudomonas aeruginosa</i> in pneumonia and bloodstream infections in the United States (MIRAGE)
Effectiveness of imipenem-relebactam for multidrug-resistant <i>Pseudomonas aeruginosa</i> in pneumonia and bloodstream infections in the United States (MIRAGE) Open
Imipenem-relebactam demonstrates in vitro activity against multidrug-resistant (MDR) Pseudomonas aeruginosa , but real-world effectiveness data are limited. MIRAGE was a multicenter, retrospective, observational study of imipenem-relebacta…
View article: Patient Acceptability of a Point-of-Care Rapid PCR Diagnostic Test for Assessment of Pharyngitis in Urgent Care
Patient Acceptability of a Point-of-Care Rapid PCR Diagnostic Test for Assessment of Pharyngitis in Urgent Care Open
View article: First Case of Neuroinvasive Oropouche Virus in Wisconsin: A Case Report
First Case of Neuroinvasive Oropouche Virus in Wisconsin: A Case Report Open
Per the Pan American Health Organization/World Health Organization, Oropouche virus (OROV) is a reemerging arbovirus that poses a yet undetermined degree of threat to the United States, with outbreaks reported in the Caribbean and South Am…
View article: 311. Defining the magnitude of desirability of outcome ranking (DOOR) differences in effectiveness of Ceftazidime-Avibactam (CZA) versus Ceftolozane-Tazobactam (C/T) for multidrug-resistant (MDR) <i>Pseudomonas aeruginosa</i> infections in the United States (CACTUS)
311. Defining the magnitude of desirability of outcome ranking (DOOR) differences in effectiveness of Ceftazidime-Avibactam (CZA) versus Ceftolozane-Tazobactam (C/T) for multidrug-resistant (MDR) <i>Pseudomonas aeruginosa</i> infections in the United States (CACTUS) Open
Background CACTUS is a retrospective, matched, multicenter study comparing the efficacy of C/T and CZA for the treatment of bacteremia or pneumonia due to MDR P. aeruginosa. We previously demonstrated that treatment with C/T resulted in hi…
View article: 312. Impact of Patient Subgroups on the Efficacy of Ceftazidime-Avibactam (CZA) versus Ceftolozane-Tazobactam (C/T) for Multidrug-resistant (MDR) <i>Pseudomonas aeruginosa</i> infections in the United States (CACTUS)
312. Impact of Patient Subgroups on the Efficacy of Ceftazidime-Avibactam (CZA) versus Ceftolozane-Tazobactam (C/T) for Multidrug-resistant (MDR) <i>Pseudomonas aeruginosa</i> infections in the United States (CACTUS) Open
Background CACTUS is a retrospective, matched, multicenter study comparing the efficacy of C/T and CZA for treatment of bacteremia or pneumonia due to MDR P. aeruginosa. We found that treatment with C/T resulted in higher rates of clinical…
View article: <i>Staphylococcus aureus</i> Bacteremia Electronic Reminder: an effective and accepted alert to consult infectious disease
<i>Staphylococcus aureus</i> Bacteremia Electronic Reminder: an effective and accepted alert to consult infectious disease Open
Infectious disease consultation improves outcomes for S. aureus bacteremia. We developed an electronic health record alert (SABER) to automatically encourage consultation and replace manual intervention. In a pre-post evaluation, high rate…
View article: The distinctive pharmacokinetic profile of rezafungin, a long-acting echinocandin developed in the era of modern pharmacometrics
The distinctive pharmacokinetic profile of rezafungin, a long-acting echinocandin developed in the era of modern pharmacometrics Open
Echinocandin drugs are the current first-line therapy for fungal infections caused by Candida spp. Most patients require once-daily intravenous (IV) administration in a hospital or outpatient setting for treatment, which may negatively imp…
View article: <i>In vivo</i> pharmacodynamic characterization of a next-generation polyene, SF001, in the invasive pulmonary aspergillosis mouse model
<i>In vivo</i> pharmacodynamic characterization of a next-generation polyene, SF001, in the invasive pulmonary aspergillosis mouse model Open
SF001 is a next-generation polyene antifungal drug in development, designed to have increased specificity to fungal ergosterol, which is absent in humans, and decreased binding to cholesterol. SF001 demonstrates long-acting, potent, broad-…
View article: A Multicenter, Observational Study to Compare the Effectiveness of Ceftazidime-Avibactam Versus Ceftolozane-Tazobactam for Multidrug-Resistant Pseudomonas Aeruginosa Infections in the United States (Cactus)
A Multicenter, Observational Study to Compare the Effectiveness of Ceftazidime-Avibactam Versus Ceftolozane-Tazobactam for Multidrug-Resistant Pseudomonas Aeruginosa Infections in the United States (Cactus) Open
View article: 2552. Comparative Pharmacodynamic Evaluation of Commonly Utilized, Oral, 1st - 3rd Generation Cephalosporins against <i>S. aureus</i> and <i>E. coli</i> in the Mouse Thigh Infection Model
2552. Comparative Pharmacodynamic Evaluation of Commonly Utilized, Oral, 1st - 3rd Generation Cephalosporins against <i>S. aureus</i> and <i>E. coli</i> in the Mouse Thigh Infection Model Open
Background Cephalexin (LEX), cefuroxime axetil (CXM), and cefpodoxime (CPD) are common oral cephalosporins used to treat gram-positive and gram-negative infections. However, there is a paucity of PK/PD analyses to inform optimal dosing reg…
View article: Understanding clinical implementation coordinators’ experiences in deploying evidence-based interventions
Understanding clinical implementation coordinators’ experiences in deploying evidence-based interventions Open
Purpose The fluoroquinolone restriction for the prevention of Clostridioides difficile infection (FIRST) trial is a multisite clinical study in which sites carry out a preauthorization process via electronic health record–based best-practi…
View article: Examining the effects of organizational influencers on the implementation of clinical innovations: A qualitative analysis
Examining the effects of organizational influencers on the implementation of clinical innovations: A qualitative analysis Open
Background: The FIRST Trial is a 5-year study funded by the Agency for Healthcare Research and Quality. Our investigation is situated within a more extensive study to restrict fluoroquinolone antibiotics by requiring providers to obtain au…
View article: Neutropenic Fever–Associated Admissions Among Patients With Solid Tumors Receiving Chemotherapy During the COVID-19 Pandemic
Neutropenic Fever–Associated Admissions Among Patients With Solid Tumors Receiving Chemotherapy During the COVID-19 Pandemic Open
This cohort study examines the rates of neutropenic fever–associated admissions and outpatient antibiotic use among patients with cancer receiving chemotherapy before and during the COVID-19 pandemic.
View article: Development of Modernized Acinetobacter baumannii Susceptibility Test Interpretive Criteria for Recommended Antimicrobial Agents Using Pharmacometric Approaches
Development of Modernized Acinetobacter baumannii Susceptibility Test Interpretive Criteria for Recommended Antimicrobial Agents Using Pharmacometric Approaches Open
Acinetobacter baumannii- Acinetobacter calcoaceticus complex (referred to herein as A. baumannii ) treatment guidelines contain numerous older antimicrobial agents with susceptibility test interpretive criteria (STIC, also known as suscept…
View article: 875. Guess Who’s Back: The Return of Seasonal Respiratory Viruses in the State of Wisconsin and Associated Changes in Antibiotic Prescribing for Respiratory Complaints
875. Guess Who’s Back: The Return of Seasonal Respiratory Viruses in the State of Wisconsin and Associated Changes in Antibiotic Prescribing for Respiratory Complaints Open
Background Return of infections caused by common respiratory viruses (RV) may be expected with the relaxation and/or removal of infection prevention measures instituted during the COVID-19 pandemic. Therefore, we examined respiratory virus…
View article: 927. Successful Implementation of an Inpatient Fluoroquinolone (FQ) Pre-Authorization (PA) Program at a Tertiary Care Academic Center and Associated Changes in Antibiotic Use, Antibiogram Susceptibility, and Provider Behavioral Changes
927. Successful Implementation of an Inpatient Fluoroquinolone (FQ) Pre-Authorization (PA) Program at a Tertiary Care Academic Center and Associated Changes in Antibiotic Use, Antibiogram Susceptibility, and Provider Behavioral Changes Open
Background In 2017, our adult tertiary care academic hospital in the Midwest implemented an inpatient fluoroquinolone (FQ) prior authorization (PA) policy using the electronic health record (EHR) as a stewardship tool. We examined the chan…
View article: Diagnostic and Therapeutic Utility of Positive Intravascular Catheter Tip Cultures
Diagnostic and Therapeutic Utility of Positive Intravascular Catheter Tip Cultures Open
In patients with intravascular catheters who are febrile or have positive blood cultures and no other obvious sources of infection, catheter tip cultures are often obtained to evaluate potential catheter-related bloodstream infections. How…
View article: Validated Preclinical Mouse Model for Therapeutic Testing against Multidrug-Resistant Pseudomonas aeruginosa Strains
Validated Preclinical Mouse Model for Therapeutic Testing against Multidrug-Resistant Pseudomonas aeruginosa Strains Open
The prevalence of antibiotic resistance among bacterial pathogens is a growing problem that necessitates the development of new antibiotics. Preclinical animal models are important tools to facilitate and speed the development of novel ant…
View article: Validated Preclinical Murine Model for Therapeutic Testing against Multidrug Resistant <i>Pseudomonas aeruginosa</i>
Validated Preclinical Murine Model for Therapeutic Testing against Multidrug Resistant <i>Pseudomonas aeruginosa</i> Open
The rise in infections caused by antibiotic resistant bacteria is outpacing the development of new antibiotics. The ESKAPE pathogens ( Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas…
View article: Clinical Utility of Dual Anterior Nares and Oropharynx MRSA Screening PCR for Patients with Suspected Pneumonia – ERRATUM
Clinical Utility of Dual Anterior Nares and Oropharynx MRSA Screening PCR for Patients with Suspected Pneumonia – ERRATUM Open
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View article: COVID-19 in Health Care Personnel
COVID-19 in Health Care Personnel Open
View article: Association of Changes in Seasonal Respiratory Virus Activity and Ambulatory Antibiotic Prescriptions With the COVID-19 Pandemic
Association of Changes in Seasonal Respiratory Virus Activity and Ambulatory Antibiotic Prescriptions With the COVID-19 Pandemic Open
This pre-post study examines the association between respiratory virus incidence and ambulatory antibiotic orders and the COVID-19 pandemic.
View article: Decreasing ICU-associated<i>Clostridioides difficile</i>infection through fluoroquinolone restriction, the FIRST trial: a study protocol
Decreasing ICU-associated<i>Clostridioides difficile</i>infection through fluoroquinolone restriction, the FIRST trial: a study protocol Open
Introduction Clostridioides difficile infection (CDI) is one of the most common healthcare-associated infections in the USA, having high incidence in intensive care units (ICU). Antibiotic use increases risk of CDI, with fluoroquinolones (…
View article: Viral Sequencing to Investigate Sources of SARS-CoV-2 Infection in US Healthcare Personnel
Viral Sequencing to Investigate Sources of SARS-CoV-2 Infection in US Healthcare Personnel Open
Background Healthcare personnel (HCP) are at increased risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We posit that current infection control guidelines generally protect HCP from SARS-CoV-2 infection …
View article: Viral sequencing reveals US healthcare personnel rarely become infected with SARS-CoV-2 through patient contact
Viral sequencing reveals US healthcare personnel rarely become infected with SARS-CoV-2 through patient contact Open
Summary Background Healthcare personnel (HCP) are at increased risk of infection with the severe acute respiratory coronavirus 2019 virus (SARS-CoV-2). Between 12 March 2020 and 10 January 2021, >1,170 HCP tested positive for SARS-CoV-2 at…
View article: Antibiotic prescribing patterns for coronavirus disease 2019 (COVID-19) in two emergency departments with rapid procalcitonin
Antibiotic prescribing patterns for coronavirus disease 2019 (COVID-19) in two emergency departments with rapid procalcitonin Open
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View article: FDA Public Workshop Summary: Advancing Animal Models for Antibacterial Drug Development
FDA Public Workshop Summary: Advancing Animal Models for Antibacterial Drug Development Open
The U.S. Food and Drug Administration (FDA) hosted a public workshop entitled “Advancing Animal Models for Antibacterial Drug Development” on 5 March 2020. The workshop mainly focused on models of pneumonia caused by Pseudomonas aeruginosa…
View article: Implementation of infection control measures to prevent healthcare-associated transmission of severe acute respiratory coronavirus virus 2 (SARS-CoV-2)
Implementation of infection control measures to prevent healthcare-associated transmission of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) Open
An abstract is not available for this content. As you have access to this content, full HTML content is provided on this page. A PDF of this content is also available in through the 'Save PDF' action button.
View article: Pharmacodynamic Evaluation of MRX-8, a Novel Polymyxin, in the Neutropenic Mouse Thigh and Lung Infection Models against Gram-Negative Pathogens
Pharmacodynamic Evaluation of MRX-8, a Novel Polymyxin, in the Neutropenic Mouse Thigh and Lung Infection Models against Gram-Negative Pathogens Open
MRX-8 is a novel polymyxin analogue in development for the treatment of infections caused by Gram-negative pathogens, including those resistant to other antibiotic classes. In the present study, we examined the pharmacodynamic activity of …