Alexander J. Stevens
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View article: Stabilization of Protein Interactions through Electrospray Additives in Negative Ion Mode Native Mass Spectrometry
Stabilization of Protein Interactions through Electrospray Additives in Negative Ion Mode Native Mass Spectrometry Open
Native mass spectrometry (nMS) is routinely used to monitor ligand binding in protein complexes. However, such interactions are easily distorted by unwanted dissociation during desolvation and ionization. This effect can be mitigated by ch…
View article: Paraquat pharmacokinetics in primates and extrapolation to humans
Paraquat pharmacokinetics in primates and extrapolation to humans Open
By extending our Paraquat (PQ) work to include primates we have implemented a modelling and simulation strategy that has enabled PQ pharmacokinetic data to be integrated into a single physiologically based pharmacokinetic (PBPK) model that…
View article: Integration of paraquat pharmacokinetic data across species using PBPK modelling
Integration of paraquat pharmacokinetic data across species using PBPK modelling Open
Paraquat dichloride (PQ) is a non-selective herbicide which has been the subject of numerous toxicology studies over more than 50 years. This paper describes the development of a physiologically-based pharmacokinetic (PBPK) model of PQ kin…
View article: Comparative metabolism of xenobiotic chemicals by cytochrome P450s in the nematode Caenorhabditis elegans
Comparative metabolism of xenobiotic chemicals by cytochrome P450s in the nematode Caenorhabditis elegans Open
We investigated the metabolic capabilities of C. elegans using compounds whose metabolism has been well characterised in mammalian systems. We find that similar metabolites are produced in C. elegans as in mammals but that C. elegans is de…
View article: The current status of exposure-driven approaches for chemical safety assessment: A cross-sector perspective
The current status of exposure-driven approaches for chemical safety assessment: A cross-sector perspective Open
For the purposes of chemical safety assessment, the value of using non-animal (in silico and in vitro) approaches and generating mechanistic information on toxic effects is being increasingly recognised. For sectors where in vivo toxicity …
View article: A systematic review of the analgesic efficacy of cannabinoid medications in the management of acute pain
A systematic review of the analgesic efficacy of cannabinoid medications in the management of acute pain Open
Background Cannabinergic medications have been postulated to demonstrate efficacy in the management of pain. The aim of this systematic review was to assess the analgesic efficacy and adverse effects of cannabinoids when used for the manag…