Alexander Kaiser
YOU?
Author Swipe
View article: Sequential Inflammatory and Matrisome Programs Drive Remodeling of the Mouse Carotid–Jugular Arteriovenous Fistula
Sequential Inflammatory and Matrisome Programs Drive Remodeling of the Mouse Carotid–Jugular Arteriovenous Fistula Open
The mouse carotid–jugular arteriovenous fistula (AVF) is a widely adopted surgical model to study venous remodeling after AVF creation. Despite its increasing use, the extent to which this model recapitulates the cellular and molecular rem…
View article: Rethinking the Kohn–Sham inverse problem
Rethinking the Kohn–Sham inverse problem Open
Density functional theory (DFT) is a cornerstone of modern electronic structure theory. In the Kohn–Sham scheme, the many-electron Schrödinger equation is replaced by a set of effective single-particle equations. Thus, the full complexity …
View article: Advanced Spiritual Knowledge Management: Main Features of the Concept and Initial Ideas for Implementation in Schools and School Pastoral Care
Advanced Spiritual Knowledge Management: Main Features of the Concept and Initial Ideas for Implementation in Schools and School Pastoral Care Open
Purpose: This paper aims to conceptualize and explore Spiritual Knowledge Management (SpKM) as an advanced and transformative paradigm within the evolving field of Knowledge Management (KM). It shifts KM’s purpose from supporting predefine…
View article: Accurate electron densities from quantum Monte Carlo calculations using real-space grids
Accurate electron densities from quantum Monte Carlo calculations using real-space grids Open
We provide accurate energies and electronic densities for Li2, C, and N2 from the diffusion Monte Carlo (DMC) method in the fixed node approximation based on orbitals from a real-space grid approach. With relatively simple single-determina…
View article: Can we Expect AI to be Wise? — A Wisdom, Knowledge (Management), Resonance, and Cognitive Science Perspective
Can we Expect AI to be Wise? — A Wisdom, Knowledge (Management), Resonance, and Cognitive Science Perspective Open
This paper investigates whether AI can possess wisdom, a complex and deeply human capacity. We adopt an interdisciplinary approach, drawing on philosophy, 4E cognition, Material Engagement Theory, and engaged epistemology, to argue that wi…
View article: Long term effects of aromatase inhibitor treatment in patients with aromatase excess syndrome
Long term effects of aromatase inhibitor treatment in patients with aromatase excess syndrome Open
Introduction Aromatase excess syndrome (AEXS) is a rare, autosomal dominant disorder, characterized by enhanced aromatization of androgens and estrogen excess. In males it is characterized by pre-/peripubertal gynecomastia, hypogonadotropi…
View article: Thermal properties of SiC-bonded diamond materials produced by liquid silicon infiltration
Thermal properties of SiC-bonded diamond materials produced by liquid silicon infiltration Open
Silicon carbide bonded diamond composites are a class of materials with great potential for a wide range of demanding applications in industry. They can be produced by pressureless infiltration of diamond preforms with liquid silicon. In a…
View article: WNT3a Signaling Inhibits Aromatase Expression in Breast Adipose Fibroblasts—A Possible Mechanism Supporting the Loss of Estrogen Responsiveness of Triple-Negative Breast Cancers
WNT3a Signaling Inhibits Aromatase Expression in Breast Adipose Fibroblasts—A Possible Mechanism Supporting the Loss of Estrogen Responsiveness of Triple-Negative Breast Cancers Open
Estrogen-dependent breast cancers rely on a constant supply of estrogens and expression of estrogen receptors. Local biosynthesis, by aromatase in breast adipose fibroblasts (BAFs), is their most important source for estrogens. Triple-nega…
View article: Introduction to the Minitrack on Reports from the Field: Knowledge and Learning Applications in Practice
Introduction to the Minitrack on Reports from the Field: Knowledge and Learning Applications in Practice Open
Welcome to this, the 54th Hawaii International Conference on System Sciences (HICSS) conference.This Reports from the Field Minitrack, under the Knowledge Innovation and Entrepreneurial Systems Track, proudly brings you the latest research…
View article: An advanced knowledge-based analysis of company vision statements
An advanced knowledge-based analysis of company vision statements Open
What distinguishes a good vision? A knowledge perspective on organizational visions can be helpful in order to identify which content vision statements should include. Knowledge enablers aim to respond to the question what organizations ne…
View article: Combinations of density functionals for accurate molecular properties of Be/W/H compounds
Combinations of density functionals for accurate molecular properties of Be/W/H compounds Open
Beryllium and tungsten species can form by plasma-induced erosion of the walls of a fusion reactor. Accurate and fast evaluation of energies and geometries of Be/W/H compounds is needed for direct molecular dynamics of the plasma-wall inte…
View article: Modelling the sputtering and reflection from a beryllium surface: atomistic analysis
Modelling the sputtering and reflection from a beryllium surface: atomistic analysis Open
Sputtering from plasma-facing surfaces upon particle impact can limit the lifetime of components in fusion devices, especially in the diverter region. Atomistic simulations of the processes associated with plasma–wall interactions allow fo…
View article: Introduction to the Minitrack on Reports from the Field: Knowledge and Learning Applications in Practice
Introduction to the Minitrack on Reports from the Field: Knowledge and Learning Applications in Practice Open
Welcome to this, the 54th Hawaii International Conference on System Sciences (HICSS) conference.This Reports from the Field Minitrack, under the Knowledge Innovation and Entrepreneurial Systems Track, proudly brings you the latest research…
View article: A Performance Benchmarking Methodology for MQTT Broker Implementations
A Performance Benchmarking Methodology for MQTT Broker Implementations Open
The rapid growth of IoT across the globe has been significant over the past decade. As the number of connected devices increases by the order of billions year over year, the capacity and operating costs of IoT networks and associated commu…
View article: Sputtering of the beryllium tungsten alloy Be<sub>2</sub>W by deuterium atoms: molecular dynamics simulations using machine learned forces
Sputtering of the beryllium tungsten alloy Be<sub>2</sub>W by deuterium atoms: molecular dynamics simulations using machine learned forces Open
Material erosion and fuel retention will limit the life and the performance of thermonuclear fusion reactors. In this work, sputtering, reflection and retention processes are atomistically modeled by simulating the non-cumulative sputterin…
View article: Time-Dependent Perspective for the Intramolecular Couplings of the N–H Stretches of Protonated Tryptophan
Time-Dependent Perspective for the Intramolecular Couplings of the N–H Stretches of Protonated Tryptophan Open
Quasi-classical direct dynamics simulations, performed with the B3LYP-D3/cc-pVDZ electronic structure theory, are reported for vibrational relaxation of the three NH stretches of the -NH3+ group of protonated tryptophan (TrpH+), excited to…
View article: Identification of PARP-1, Histone H1 and SIRT-1 as New Regulators of Breast Cancer-Related Aromatase Promoter I.3/II
Identification of PARP-1, Histone H1 and SIRT-1 as New Regulators of Breast Cancer-Related Aromatase Promoter I.3/II Open
Paracrine interactions between malignant estrogen receptor positive (ER+) breast cancer cells and breast adipose fibroblasts (BAFs) stimulate estrogen biosynthesis by aromatase in BAFs. In breast cancer, mainly the cAMP-responsive promoter…
View article: Introduction to the Minitrack on Reports from the Field: Knowledge and Learning Applications in Practice
Introduction to the Minitrack on Reports from the Field: Knowledge and Learning Applications in Practice Open
Welcome to this, the 53rd Hawaii International Conference on System Sciences (HICSS) conference.This Reports from the Field Minitrack, under the Knowledge Innovation and Entrepreneurial Systems Track, proudly brings you the latest research…
View article: Iterative training set refinement enables reactive molecular dynamics <i>via</i> machine learned forces
Iterative training set refinement enables reactive molecular dynamics <i>via</i> machine learned forces Open
Reactive self-sputtering from a Be surface is simulated using neural network trained forces with high accuracy. The key in machine learning from DFT calculations is a well-balanced and complete training set of energies and forces obtained …
View article: Performance of DFT functionals for properties of small molecules containing beryllium, tungsten and hydrogen
Performance of DFT functionals for properties of small molecules containing beryllium, tungsten and hydrogen Open
A comparative study of bond lengths, atomization energies and vibrational frequencies for a set of neutral molecules Ben, BenHm, Wn, WnBem, and WnHm with m + n ≤ 4 in their ground state is presented. We compare 16 density functionals chose…
View article: Age of discovery: navigating the balance between human and machine
Age of discovery: navigating the balance between human and machine Open
No description available
View article: A neural network interface for DL_POLY and its application to liquid water
A neural network interface for DL_POLY and its application to liquid water Open
After a general discussion of neural networks potential energy functions and their standing within the various approaches of representing the potential energy function of a system, we describe a new interface between the open source atomis…
View article: Beryllium, tungsten and their alloys Be2W and Be12W: Surface defect energetics from density functional theory calculations
Beryllium, tungsten and their alloys Be2W and Be12W: Surface defect energetics from density functional theory calculations Open
The binding, adsorption and removal energies of atoms on the surfaces of Be with the major orientations (112¯0) and (112¯1), and of W and Be/W alloys with (110) and (111) orientations have been obtained from density functional theory calcu…
View article: Highly Stable [C<sub>60</sub>AuC<sub>60</sub>]<sup>+/–</sup> Dumbbells
Highly Stable [C<sub>60</sub>AuC<sub>60</sub>]<sup>+/–</sup> Dumbbells Open
Ionic complexes between gold and C60 have been observed for the first time. Cations and anions of the type [Au(C60)2]+/- are shown to have particular stability. Calculations suggest that these ions adopt a C60-Au-C60 sandwich-like (dumbbel…
View article: Isomeric Broadening of C<sub>60</sub><sup>+</sup> Electronic Excitation in Helium Droplets: Experiments Meet Theory
Isomeric Broadening of C<sub>60</sub><sup>+</sup> Electronic Excitation in Helium Droplets: Experiments Meet Theory Open
Helium is considered an almost ideal tagging atom for cold messenger spectroscopy experiments. Although helium is bound very weakly to the ionic molecule of interest, helium tags can lead to shifts and broadenings that we recorded near 963…