Alexander Karnowski
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View article: Alpha-1 antitrypsin reduces inflammation and vasculopathy in mice with oxygen-induced retinopathy
Alpha-1 antitrypsin reduces inflammation and vasculopathy in mice with oxygen-induced retinopathy Open
Background Damage to the retinal vasculature is a major cause of vision loss and is influenced by a pro-inflammatory environment within retinal tissue. Alpha-1 antitrypsin (AAT) is a potent inhibitor of serine proteases and has anti-inflam…
View article: Evaluation of Phage Display Biopanning Strategies for the Selection of Anti-Cell Surface Receptor Antibodies
Evaluation of Phage Display Biopanning Strategies for the Selection of Anti-Cell Surface Receptor Antibodies Open
Monoclonal antibodies (mAbs) are one of the most successful and versatile protein-based pharmaceutical products used to treat multiple pathological conditions. The remarkable specificity of mAbs and their affinity for biological targets ha…
View article: Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins
Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins Open
Antibody Secreting Cells (ASCs) are a fundamental component of humoral immunity, however, deregulated or excessive antibody production contributes to the pathology of autoimmune diseases, while transformation of ASCs results in the maligna…