Alexander Kiefer
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View article: Timely Association of RSV Hospitalisation Waves in Children with the Detection of SARS-CoV-2 in the General Population in Eastern Bavaria
Timely Association of RSV Hospitalisation Waves in Children with the Detection of SARS-CoV-2 in the General Population in Eastern Bavaria Open
Background: The Respiratory Syncytial Virus (RSV) season of 2023/2024 was conspicuously different from previous seasons, with an abrupt decrease in hospitalisation rates at the peak of the season, leading to two lower peaks instead of the …
View article: Complementary Predictors for Asthma Attack Prediction in Children: Salivary Microbiome, Serum Inflammatory Mediators, and Past Attack History
Complementary Predictors for Asthma Attack Prediction in Children: Salivary Microbiome, Serum Inflammatory Mediators, and Past Attack History Open
Background Early identification of children at risk of asthma attacks is important for optimizing treatment strategies. We aimed to integrate salivary microbiome and serum inflammatory mediator profiles with asthma attacks history to devel…
View article: Persistently high burden of acute respiratory infections requiring hospitalization in German pediatric hospitals, fall/winter 2023–2024
Persistently high burden of acute respiratory infections requiring hospitalization in German pediatric hospitals, fall/winter 2023–2024 Open
Purpose During fall 2021, children’s hospitals in Germany faced a surge in RSV-related hospitalizations, whereas during fall/winter 2022–2023, RSV and influenza infections both led to increased inpatient admissions. Our study prospectively…
View article: RSV is the main cause of severe respiratory infections in infants and young children in Germany - data from the prospective, multicenter PAPI study 2021–2023
RSV is the main cause of severe respiratory infections in infants and young children in Germany - data from the prospective, multicenter PAPI study 2021–2023 Open
Summary Background Respiratory syncytial virus (RSV) is one of the main causes of morbidity in infants and young children worldwide. Current data on RSV-associated disease burden in Germany before the introduction of new immunization strat…
View article: Healthcare worker views on antimicrobial resistance in chronic respiratory disease
Healthcare worker views on antimicrobial resistance in chronic respiratory disease Open
View article: Beeinflusst der RSV-Serotyp den Schweregrad der Bronchiolitis bei hospitalisierten Säuglingen und Kleinkindern? Daten aus der multizentrischen PAPI-Studie.
Beeinflusst der RSV-Serotyp den Schweregrad der Bronchiolitis bei hospitalisierten Säuglingen und Kleinkindern? Daten aus der multizentrischen PAPI-Studie. Open
Hintergrund Das Respiratorische Synzytial Virus (RSV) ist ein häufiges saisonales Atemwegs-Pathogen und insbesondere bei Säuglingen und Kleinkindern mit signifikanter Morbidität assoziiert. Bisher wird der Serotyp RSV A mit schweren Erkran…
View article: VitaminD3 regulates T cell immune responses in allergen and Rhinovirus induced asthma
VitaminD3 regulates T cell immune responses in allergen and Rhinovirus induced asthma Open
Background: Serum 25(OH)-Vitamin D3 (VitD3) deficiency during infancy has been associated with asthma. The potential therapeutic role of VitD3 given in the airways and its interference with the allergen and Rhinovirus was the objective of …
View article: Impact of elexacaftor/tezacaftor/ivacaftor on lung function, nutritional status, pulmonary exacerbation frequency and sweat chloride in people with cystic fibrosis: real-world evidence from the German CF Registry
Impact of elexacaftor/tezacaftor/ivacaftor on lung function, nutritional status, pulmonary exacerbation frequency and sweat chloride in people with cystic fibrosis: real-world evidence from the German CF Registry Open
View article: The frequency of hospitalizations for RSV and influenza among children and adults—an analysis from the years 2016–2022
The frequency of hospitalizations for RSV and influenza among children and adults—an analysis from the years 2016–2022 Open
View article: Vitamin D3 resolved human and experimental asthma via B lymphocyte–induced maturation protein 1 in T cells and innate lymphoid cells
Vitamin D3 resolved human and experimental asthma via B lymphocyte–induced maturation protein 1 in T cells and innate lymphoid cells Open
View article: Safety and efficacy of vanzacaftor–tezacaftor–deutivacaftor in adults with cystic fibrosis: randomised, double-blind, controlled, phase 2 trials
Safety and efficacy of vanzacaftor–tezacaftor–deutivacaftor in adults with cystic fibrosis: randomised, double-blind, controlled, phase 2 trials Open
View article: Targeted deletion of Interleukin-3 results in asthma exacerbations
Targeted deletion of Interleukin-3 results in asthma exacerbations Open
The cytokine interleukin-3 (IL-3) acts on early hematopoietic precursor cells. In humans, Treg cells secrete IL-3 and repress inflammatory cells except for basophils. The present study aims to elucidate the contribution of IL-3 …
View article: DMBT1 is upregulated in cystic fibrosis, affects ciliary motility, and is reduced by acetylcysteine
DMBT1 is upregulated in cystic fibrosis, affects ciliary motility, and is reduced by acetylcysteine Open
View article: Validation of the LEOSound® monitor for standardized detection of wheezing and cough in children
Validation of the LEOSound® monitor for standardized detection of wheezing and cough in children Open
Background A hallmark of many respiratory conditions is the presence of nocturnal symptoms. Nevertheless, especially in children there is currently still a huge diagnostic gap in detecting nighttime symptoms, which leads to an underestimat…
View article: Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma
Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma Open
View article: VitaminD3 Regulates T Cell Immune Responses in Allergen and Rhinovirus Induced Asthma
VitaminD3 Regulates T Cell Immune Responses in Allergen and Rhinovirus Induced Asthma Open
Background: Serum 25(OH)-Vitamin D3 (VitD3) deficiency during infancy has been associated with asthma. The potential therapeutic role of VitD3 given in the airways and its interference with the allergen and Rhinovirus was the objective of …
View article: TLR7/8 regulates type I and type III interferon signalling in rhinovirus 1b-induced allergic asthma
TLR7/8 regulates type I and type III interferon signalling in rhinovirus 1b-induced allergic asthma Open
Introduction Interferon (IFN) responses have been reported to be defective in rhinovirus (RV)-induced asthma. The heterodimeric receptor of type I IFN (IFN-α/β) is composed of IFN-αR1 and IFN-αR2. Ligand binding to the IFN-α/β receptor com…
View article: Role of nuclear factor of activated T cells 2 (NFATc2) in allergic asthma
Role of nuclear factor of activated T cells 2 (NFATc2) in allergic asthma Open
Background We recently described increased NFATc1, IRF4 , and NIP45 messenger RNA (mRNA) expression in peripheral blood mononuclear cells (PBMCs) of asthmatic children and adults with multiple allergies. Objective NFATc2 has been described…
View article: COVID-19 bei Kindern und Jugendlichen mit chronischen Lungenerkrankungen
COVID-19 bei Kindern und Jugendlichen mit chronischen Lungenerkrankungen Open
View article: Role of Nuclear Factor of Activated T cells 2 (NFATc2) in allergic asthma
Role of Nuclear Factor of Activated T cells 2 (NFATc2) in allergic asthma Open
Background: We recently described increased NFATc1, IRF4, and NIP45 messenger RNA (mRNA) expression in peripheral blood mononuclear cells (PBMCs) of asthmatic children and adults with multiple allergies. Objective: NFATc2 has been describe…
View article: Dual-source computed tomography of the lung with spectral shaping and advanced iterative reconstruction: potential for maximum radiation dose reduction
Dual-source computed tomography of the lung with spectral shaping and advanced iterative reconstruction: potential for maximum radiation dose reduction Open
View article: Respiratory infections regulated blood cells IFN‐β‐PD‐L1 pathway in pediatric asthma
Respiratory infections regulated blood cells IFN‐β‐PD‐L1 pathway in pediatric asthma Open
Background Respiratory infections, in general, and rhinovirus infection specifically are the main reason for asthma exacerbation in children and programmed cell death protein 1 ligand (PD‐L1) expression inhibits T cell responses. Objective…
View article: ILC2 Lung-Homing in Cystic Fibrosis Patients: Functional Involvement of CCR6 and Impact on Respiratory Failure
ILC2 Lung-Homing in Cystic Fibrosis Patients: Functional Involvement of CCR6 and Impact on Respiratory Failure Open
Cystic fibrosis patients suffer from a progressive, often fatal lung disease, which is based on a complex interplay between chronic infections, locally accumulating immune cells and pulmonary tissue remodeling. Although group-2 innate lymp…
View article: Respiratory infections regulated blood cells IFN-beta-PD-L1 pathway in pediatric asthma
Respiratory infections regulated blood cells IFN-beta-PD-L1 pathway in pediatric asthma Open
Respiratory infections in general and rhinovirus (RV) infection specifically are the main reason for asthma exacerbation in children. Here we found increased level of Programmed cell death protein 1 ligand (PD-L1) mRNA in total blood cells…
View article: Regulated on Activation, Normal T Cell Expressed and Secreted Drives the Resolution of Allergic Asthma
Regulated on Activation, Normal T Cell Expressed and Secreted Drives the Resolution of Allergic Asthma Open
View article: [COVID-19 in children and adolescents with chronic lung diseases].
[COVID-19 in children and adolescents with chronic lung diseases]. Open
View article: Targeted deletion of NFAT-Interacting-Protein-(NIP) 45 resolves experimental asthma by inhibiting Innate Lymphoid Cells group 2 (ILC2)
Targeted deletion of NFAT-Interacting-Protein-(NIP) 45 resolves experimental asthma by inhibiting Innate Lymphoid Cells group 2 (ILC2) Open
View article: Successful eradication of newly acquired MRSA in six of seven patients with cystic fibrosis applying a short-term local and systemic antibiotic scheme
Successful eradication of newly acquired MRSA in six of seven patients with cystic fibrosis applying a short-term local and systemic antibiotic scheme Open
View article: Correction: Corrigendum: IL-33/ST2 immune responses to respiratory bacteria in pediatric asthma
Correction: Corrigendum: IL-33/ST2 immune responses to respiratory bacteria in pediatric asthma Open
View article: IL-33/ST2 immune responses to respiratory bacteria in pediatric asthma
IL-33/ST2 immune responses to respiratory bacteria in pediatric asthma Open