Alexander Kluttig
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View article: Association of a Lifestyle Risk Index With Visceral and Subcutaneous Adipose Tissue in the German National Cohort ( <scp>NAKO</scp> )
Association of a Lifestyle Risk Index With Visceral and Subcutaneous Adipose Tissue in the German National Cohort ( <span>NAKO</span> ) Open
Objective This cross‐sectional study examined a Lifestyle Risk Factor Index ( LSRI ) in relation to adiposity measures including visceral adipose tissue ( VAT ) in the German National Cohort ( NAKO ). Methods Based on self‐reports at basel…
View article: Research with cancer registry data in radiation oncology—current possibilities and perspectives
Research with cancer registry data in radiation oncology—current possibilities and perspectives Open
Clinical background Cancer registry data are an essential resource for population-based oncology research and quality assurance in Germany. With the revision of the Federal Cancer Registry Data Act in 2021, for the first time, a legal basi…
View article: #3563 Elevated urine albumin-creatinine ratio associates with higher pulse-wave velocity in a population-based cohort
#3563 Elevated urine albumin-creatinine ratio associates with higher pulse-wave velocity in a population-based cohort Open
Background and Aims Moderately elevated albumin excretion in the urine, semiquantified by the urine albumin-creatinine ratio (uACR), has been shown to increase the risk for vascular or renal end-points in patients with diabetes mellitus, a…
View article: Cognitive flexibility in aging: the impact of age range and task difficulty on local switch costs in task switching
Cognitive flexibility in aging: the impact of age range and task difficulty on local switch costs in task switching Open
Introduction Previous studies provided inconclusive results regarding the effects of aging on the ability to flexibly switch between task rules (local switch cost). The goal of the present study was to investigate the influence of age on t…
View article: Erratum zu: Messung der körperlichen Fitness in der NAKO Gesundheitsstudie – Methoden, Qualitätssicherung und erste deskriptive Ergebnisse
Erratum zu: Messung der körperlichen Fitness in der NAKO Gesundheitsstudie – Methoden, Qualitätssicherung und erste deskriptive Ergebnisse Open
View article: Physiological serum uric acid concentrations correlate with arterial stiffness in a sex-dependent manner
Physiological serum uric acid concentrations correlate with arterial stiffness in a sex-dependent manner Open
View article: Allostatic load and its determinants in a German sample—Results from the Carla cohort
Allostatic load and its determinants in a German sample—Results from the Carla cohort Open
Background Allostatic load (AL) is a surrogate of the physiological response to stress and reflects the ‘wear and tear’ on the body. Previous studies indicated that socioeconomic and behavioral determinants influence AL, which in turn is a…
View article: The baseline examinations of the German National Cohort (NAKO): recruitment protocol, response, and weighting
The baseline examinations of the German National Cohort (NAKO): recruitment protocol, response, and weighting Open
The German National Cohort (NAKO) is the largest population-based epidemiologic cohort study in Germany and investigates the causes of the most common chronic diseases. Between 2014 and 2019, a total of 1.3 million residents aged 20–69 yea…
View article: Sex Differences in the Relationship of Socioeconomic Position With Cardiovascular Disease, Cardiovascular Risk Factors, and Estimated Cardiovascular Disease Risk: Results of the German National Cohort
Sex Differences in the Relationship of Socioeconomic Position With Cardiovascular Disease, Cardiovascular Risk Factors, and Estimated Cardiovascular Disease Risk: Results of the German National Cohort Open
Background Using data from the largest German cohort study, we aimed to investigate sex differences in the relationship of socioeconomic position (SEP) with cardiovascular disease (CVD), CVD risk factors, and estimated CVD risk. Methods an…
View article: Dental and oral health assessments in the German National Cohort (NAKO)
Dental and oral health assessments in the German National Cohort (NAKO) Open
View article: Diurnal timing of physical activity in relation to obesity and diabetes in the German National Cohort (NAKO)
Diurnal timing of physical activity in relation to obesity and diabetes in the German National Cohort (NAKO) Open
Background Physical activity supports weight regulation and metabolic health, but its timing in relation to obesity and diabetes remains unclear. We aimed to assess the diurnal timing of physical activity and its association with obesity a…
View article: Secondary Resections and Survival After Breast-Conserving Surgery in Breast Cancer Patients: A Cancer Registry-Based Cohort Study
Secondary Resections and Survival After Breast-Conserving Surgery in Breast Cancer Patients: A Cancer Registry-Based Cohort Study Open
Breast cancer remains the most common malignancy in women, and breast-conserving surgery (BCS) with adjuvant radiotherapy is a standard treatment for early-stage disease. This study assessed the impact of positive surgical margins and seco…
View article: Modeling Chronic Disease Mortality by Methods From Accelerated Life Testing
Modeling Chronic Disease Mortality by Methods From Accelerated Life Testing Open
We propose a parametric model for describing chronic disease mortality from cohort data and illustrate its use for Type 2 diabetes. The model uses ideas from accelerated life testing in reliability theory and conceptualizes the occurrence …
View article: SoccHealth: a health status examination of former professional football (soccer) players within the German National Cohort
SoccHealth: a health status examination of former professional football (soccer) players within the German National Cohort Open
The long-term health effects of football (soccer) have received significant attention in recent years. While brain health is currently the focus of this interest, potential long-term risks or benefits related to cardiovascular and metaboli…
View article: Associations of occupational and leisure-time physical activity with all-cause mortality: an individual participant data meta-analysis
Associations of occupational and leisure-time physical activity with all-cause mortality: an individual participant data meta-analysis Open
Objective Health effects of different physical activity domains (ie, during leisure time, work and transport) are generally considered positive. Using Active Worker consortium data, we assessed independent associations of occupational and …
View article: Impact of QRS misclassifications on heart-rate-variability parameters (results from the CARLA cohort study)
Impact of QRS misclassifications on heart-rate-variability parameters (results from the CARLA cohort study) Open
Background Heart rate variability (HRV), an important marker of autonomic nervous system activity, is usually determined from electrocardiogram (ECG) recordings corrected for extrasystoles and artifacts. Especially in large population-base…
View article: The association between the child’s age and mothers’ physical activity: results from the population-based German National Cohort study
The association between the child’s age and mothers’ physical activity: results from the population-based German National Cohort study Open
Background Since physical activity is an important determinant of physical and mental health, lower levels of physical activity among mothers reported in previous research are concerning. The aim of this study was to examine whether physic…
View article: ER stress inhibition enhances formation of triacylglcerols and protects endothelial cells from lipotoxicity
ER stress inhibition enhances formation of triacylglcerols and protects endothelial cells from lipotoxicity Open
Elevated concentrations of palmitate in serum of obese individuals can impair endothelial function, contributing to development of cardiovascular disease. Although several molecular mechanisms of palmitate-induced endothelial dysfunction h…
View article: Large-scale assessment of physical activity in a population using high-resolution hip-worn accelerometry: the German National Cohort (NAKO)
Large-scale assessment of physical activity in a population using high-resolution hip-worn accelerometry: the German National Cohort (NAKO) Open
View article: Changes in physical activity and sedentary behavior during the first COVID-19 pandemic- restrictions in Germany: a nationwide survey
Changes in physical activity and sedentary behavior during the first COVID-19 pandemic- restrictions in Germany: a nationwide survey Open
View article: Smoking is associated with increased eryptosis, suicidal erythrocyte death, in a large population-based cohort
Smoking is associated with increased eryptosis, suicidal erythrocyte death, in a large population-based cohort Open
View article: Chronic disease outcome metadata from German observational studies – public availability and FAIR principles
Chronic disease outcome metadata from German observational studies – public availability and FAIR principles Open
View article: Association between vitamin D status and eryptosis–results from the German National Cohort Study
Association between vitamin D status and eryptosis–results from the German National Cohort Study Open
Vitamin D, besides its classical effect on mineral homeostasis and bone remodeling, can also modulate apoptosis. A special form of apoptosis termed eryptosis appears in erythrocytes. Eryptosis is characterized by cell shrinkage, membrane b…
View article: 60 years of healthy aging: On definitions, biomarkers, scores and challenges
60 years of healthy aging: On definitions, biomarkers, scores and challenges Open
When deducting research, scientists need to consider the diverse challenges in defining and measuring healthy aging. Considering that, we recommend scores that combine multiple aspects of healthy aging, such as the Healthy Ageing Index or …
View article: Physical activity trajectories at older age and all-cause mortality: A cohort study
Physical activity trajectories at older age and all-cause mortality: A cohort study Open
Background A physically active lifestyle is recognized as a precondition of healthy aging. However, the majority of studies exploring its association with mortality in cohorts of adults used single-time physical activity (PA) estimate, whi…
View article: Grip strength values and cut-off points based on over 200,000 adults of the German National Cohort - a comparison to the EWGSOP2 cut-off points
Grip strength values and cut-off points based on over 200,000 adults of the German National Cohort - a comparison to the EWGSOP2 cut-off points Open
Background The European Working Group on Sarcopenia in Older People (EWGSOP) updated in 2018 the cut-off points for low grip strength to assess sarcopenia based on pooled data from 12 British studies. Objective Comparison of the EWGSOP2 cu…
View article: Framework and baseline examination of the German National Cohort (NAKO)
Framework and baseline examination of the German National Cohort (NAKO) Open
View article: Birth Order, Caesarean Section, or Daycare Attendance in Relation to Child- and Adult-Onset Type 1 Diabetes: Results from the German National Cohort
Birth Order, Caesarean Section, or Daycare Attendance in Relation to Child- and Adult-Onset Type 1 Diabetes: Results from the German National Cohort Open
(1) Background: Global incidence of type 1 diabetes (T1D) is rising and nearly half occurred in adults. However, it is unclear if certain early-life childhood T1D risk factors were also associated with adult-onset T1D. This study aimed to …
View article: Association of arterial stiffness and heart failure with preserved ejection fraction in the elderly population – results from the CARLA study
Association of arterial stiffness and heart failure with preserved ejection fraction in the elderly population – results from the CARLA study Open
View article: Increase in mental disorders during the COVID-19 pandemic—the role of occupational and financial strains. An analysis of the German National Cohort (NAKO) Study
Increase in mental disorders during the COVID-19 pandemic—the role of occupational and financial strains. An analysis of the German National Cohort (NAKO) Study Open
Depressive symptoms and anxiety disorders increased slightly in the study population during the first year of the COVID-19 pandemic. Occupational and financial difficulties were an essential contributory factor. These strains should be tak…