Alexander Krogmann
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View article: Cyclodextrin reduces cholesterol crystal uptake by circulating monocytes in patients undergoing coronary angiography
Cyclodextrin reduces cholesterol crystal uptake by circulating monocytes in patients undergoing coronary angiography Open
Background Atherosclerosis is a chronic inflammatory disease driven by endothelial dysfunction, cholesterol accumulation, and immune activation leading to thrombosis and vascular stenosis. While LDL-lowering therapies are firmly establishe…
View article: A smartphone-guided secondary prevention digital health application reduces systolic blood pressure in patients with chronic coronary syndrome and insufficient blood pressure control
A smartphone-guided secondary prevention digital health application reduces systolic blood pressure in patients with chronic coronary syndrome and insufficient blood pressure control Open
Background Chronic coronary syndrome (CCS) leads to high morbidity and mortality despite therapeutic advances in recent decades. Several modifiable risk factors, including increased blood pressure (BP), significantly contribute to cardiova…
View article: A prospective, randomized, controlled, multicentre trial for secondary prevention in patients with chronic coronary syndrome using a smartphone application for digital therapy: the CHANGE study protocol
A prospective, randomized, controlled, multicentre trial for secondary prevention in patients with chronic coronary syndrome using a smartphone application for digital therapy: the CHANGE study protocol Open
Aims Coronary artery disease (CAD) remains the leading cause of death worldwide. ‘Stable’ CAD is a chronic progressive condition, which recent European guidelines recommend referring to as ‘chronic coronary syndrome’ (CCS). Despite therape…
View article: Intracranial haemorrhage in adult patients on venoarterial extracorporeal membrane oxygenation
Intracranial haemorrhage in adult patients on venoarterial extracorporeal membrane oxygenation Open
Aims Intracranial haemorrhage (ICH) is one of the most serious complications of adult patients treated with venoarterial extracorporeal membrane oxygenation (VA-ECMO) and is associated with increased morbidity and mortality. However, the p…
View article: AIM2 Stimulation Impairs Reendothelialization and Promotes the Development of Atherosclerosis in Mice
AIM2 Stimulation Impairs Reendothelialization and Promotes the Development of Atherosclerosis in Mice Open
Background: Atherosclerosis has been shown to result from chronic inflammation caused by constitutive activation of the pattern recognition receptors (PRR), which are principle effectors of the innate immune system. PRR are present in the …
View article: Toll-Like Receptor 7 Stimulation Promotes the Development of Atherosclerosis in Apolipoprotein E-Deficient Mice
Toll-Like Receptor 7 Stimulation Promotes the Development of Atherosclerosis in Apolipoprotein E-Deficient Mice Open
Atherosclerosis is a chronic inflammatory disease with multiple characteristic facets, including vascular inflammation, endothelial dysfunction, plaque development, impaired blood flow, and cholesterol deposition through dyslipidemia. Toll…
View article: <scp>MDA</scp>‐5 activation by cytoplasmic double‐stranded <scp>RNA</scp> impairs endothelial function and aggravates atherosclerosis
<span>MDA</span>‐5 activation by cytoplasmic double‐stranded <span>RNA</span> impairs endothelial function and aggravates atherosclerosis Open
Recent studies have highlighted the relevance of viral nucleic acid immunorecognition by pattern recognition receptors in atherogenesis. Melanoma differentiation associated gene 5 ( MDA ‐5) belongs to the intracellular retinoic acid induci…
View article: Proinflammatory Stimulation of Toll-Like Receptor 9 with High Dose CpG ODN 1826 Impairs Endothelial Regeneration and Promotes Atherosclerosis in Mice
Proinflammatory Stimulation of Toll-Like Receptor 9 with High Dose CpG ODN 1826 Impairs Endothelial Regeneration and Promotes Atherosclerosis in Mice Open
Systemic stimulation of TLR9 with high dose CpG ODN impaired reendothelialization upon acute vascular injury and increased atherosclerotic plaque development in ApoE-/- mice. Further studies are necessary to fully decipher the contradictor…