Alexander O. Brachmann
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View article: Heterologous pulcherrimin production in <i>Saccharomyces cerevisiae</i> confers inhibitory activity on <i>Botrytis</i> conidiation
Heterologous pulcherrimin production in <i>Saccharomyces cerevisiae</i> confers inhibitory activity on <i>Botrytis</i> conidiation Open
Pulcherrimin is an iron (III) chelate of pulcherriminic acid that plays a role in antagonistic microbial interactions, iron metabolism, and stress responses. Some bacteria and yeasts produce pulcherriminic acid, but so far, pulcherrimin co…
View article: Author Correction: Engineering the stambomycin modular polyketide synthase yields 37-membered mini-stambomycins
Author Correction: Engineering the stambomycin modular polyketide synthase yields 37-membered mini-stambomycins Open
View article: Engineering the stambomycin modular polyketide synthase yields 37-membered mini-stambomycins
Engineering the stambomycin modular polyketide synthase yields 37-membered mini-stambomycins Open
View article: Pathogen invasion-dependent tissue reservoirs and plasmid-encoded antibiotic degradation boost plasmid spread in the gut
Pathogen invasion-dependent tissue reservoirs and plasmid-encoded antibiotic degradation boost plasmid spread in the gut Open
Many plasmids encode antibiotic resistance genes. Through conjugation, plasmids can be rapidly disseminated. Previous work identified gut luminal donor/recipient blooms and tissue-lodged plasmid-bearing persister cells of the enteric patho…
View article: Author response: Pathogen invasion-dependent tissue reservoirs and plasmid-encoded antibiotic degradation boost plasmid spread in the gut
Author response: Pathogen invasion-dependent tissue reservoirs and plasmid-encoded antibiotic degradation boost plasmid spread in the gut Open
View article: Cytotoxic potential of Allium sativum L. roots and their green synthesized nanoparticles supported with metabolomics and molecular docking analyses
Cytotoxic potential of Allium sativum L. roots and their green synthesized nanoparticles supported with metabolomics and molecular docking analyses Open
Allium sativum L. (garlic) has received a growing interest as both a food plant and folk remedy with promising antitumor and chemopreventive potential. So far, a large body of research has been conducted on garlic, mostly focusing on the b…
View article: Front Cover: Activation, Structure, Biosynthesis and Bioactivity of Glidobactin‐like Proteasome Inhibitors from <i>Photorhabdus laumondii</i> (ChemBioChem 9/2021)
Front Cover: Activation, Structure, Biosynthesis and Bioactivity of Glidobactin‐like Proteasome Inhibitors from <i>Photorhabdus laumondii</i> (ChemBioChem 9/2021) Open
Glidobactin-like proteasome inhibitors are regarded as promising candidates for anticancer drug development. We report the largest subset of glidobactin-like proteasome inhibitors, which were produced and identified after the silent biosyn…
View article: Successes, surprises and pitfalls in modular polyketide synthase engineering: generation of ring-contracted stambomycins
Successes, surprises and pitfalls in modular polyketide synthase engineering: generation of ring-contracted stambomycins Open
The modular organization of the type I polyketide synthases (PKSs) would seem propitious for rational engineering of desirable analogous. However, despite decades of efforts, such experiments remain largely inefficient. Here, we combined m…
View article: Activation, Structure, Biosynthesis and Bioactivity of Glidobactin‐like Proteasome Inhibitors from <i>Photorhabdus laumondii</i>
Activation, Structure, Biosynthesis and Bioactivity of Glidobactin‐like Proteasome Inhibitors from <i>Photorhabdus laumondii</i> Open
The glidobactin‐like natural products (GLNPs) glidobactin A and cepafungin I have been reported to be potent proteasome inhibitors and are regarded as promising candidates for anticancer drug development. Their biosynthetic gene cluster (B…
View article: Escherichia coli limits Salmonella Typhimurium infections after diet shifts and fat-mediated microbiota perturbation in mice
Escherichia coli limits Salmonella Typhimurium infections after diet shifts and fat-mediated microbiota perturbation in mice Open
View article: The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin
The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin Open
Colibactin-producing Escherichia coli strains are associated with cancerous and precancerous colorectal tissues and are suspected of promoting colorectal carcinogenesis. In this study, we describe a new interplay between the synthesis of t…
View article: Snf2 controls pulcherriminic acid biosynthesis and antifungal activity of the biocontrol yeast <i>Metschnikowia pulcherrima</i>
Snf2 controls pulcherriminic acid biosynthesis and antifungal activity of the biocontrol yeast <i>Metschnikowia pulcherrima</i> Open
Summary Metschnikowia pulcherrima synthesises the pigment pulcherrimin, from cyclodileucine (cyclo(Leu‐Leu)) as a precursor, and exhibits strong antifungal activity against notorious plant pathogenic fungi. This yeast therefore has great p…
View article: Snf2 controls pulcherriminic acid biosynthesis and connects pigmentation and antifungal activity of the yeast<i>Metschnikowia pulcherrima</i>
Snf2 controls pulcherriminic acid biosynthesis and connects pigmentation and antifungal activity of the yeast<i>Metschnikowia pulcherrima</i> Open
Metschnikowia pulcherrima synthesizes the red pigment pulcherrimin, from cyclodileucine (cyclo(Leu-Leu)) as a precursor, and exhibits strong antifungal activity against notorious plant pathogenic fungi such as Botrytis and Gibberella (i.e.…
View article: High iron supply inhibits the synthesis of the genotoxin colibactin by pathogenic Escherichia coli through a non-canonical Fur/RyhB-mediated pathway
High iron supply inhibits the synthesis of the genotoxin colibactin by pathogenic Escherichia coli through a non-canonical Fur/RyhB-mediated pathway Open
The genotoxin colibactin is a secondary metabolite produced by a variety of pathogenic Enterobacteria, and is associated with colon cancer development and acute systemic infections. The colibactin biosynthesis requires the enzymatic activi…
View article: Fast direct detection of natural dyes in historic and prehistoric textiles by flowprobe™-ESI-HRMS
Fast direct detection of natural dyes in historic and prehistoric textiles by flowprobe™-ESI-HRMS Open
Dyestuff analyses were performed directly from the surface of different bluish and reddish colored historic textile samples by flowprobe™-electrospray ionization-high-resolution mass spectrometry (flowprobe™-ESI-HRMS). This real-time in si…
View article: The Bacterial Stress-Responsive Hsp90 Chaperone (HtpG) Is Required for the Production of the Genotoxin Colibactin and the Siderophore Yersiniabactin in<i>Escherichia coli</i>
The Bacterial Stress-Responsive Hsp90 Chaperone (HtpG) Is Required for the Production of the Genotoxin Colibactin and the Siderophore Yersiniabactin in<i>Escherichia coli</i> Open
The genotoxin colibactin, synthesized by Escherichia coli, is a secondary metabolite belonging to the chemical family of hybrid polyketide/nonribosomal peptide compounds. It is produced by a complex biosynthetic assembly line encoded by th…
View article: A <i>Photorhabdus</i> Natural Product Inhibits Insect Juvenile Hormone Epoxide Hydrolase
A <i>Photorhabdus</i> Natural Product Inhibits Insect Juvenile Hormone Epoxide Hydrolase Open
Simple urea compounds (“phurealipids”) have been identified from the entomopathogenic bacterium Photorhabdus luminescens , and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as i…