Explanipedia

Formation and Discharge of Zn Sponge Anodes, Followed by Synchrotron Hard X-ray Imaging Open

Benedetto Bozzini, Nicola Sodini, Alexander P. Kao, Alessio Veneziano, Lucia Mancini · 2025

The fabrication of engineered Zn anodes often relies on different forms of ZnO as the material in direct contact with the alkaline aqueous electrolyte in the pristine assembled cell state. Of course, in this case, the as-assembled cell is …

Multi-material 3D printed composites inspired by nacre: a hard/soft mechanical interplay Open

Marco Curto, James Dowsett, Alexander P. Kao, Gianluca Tozzi, Asa H. Barber · 2025

Structural materials are used extensively in nature where mechanical function is required. These structures are composites consisting of soft and, in some cases, hard phases precisely distributed over different length scales. Bio-inspirati…

Multi-material 3D printed composites inspired by nacre: a hard/soft mechanical interplay Open

Marco Curto, James Dowsett, Alexander P. Kao, Gianluca Tozzi, Asa H. Barber · 2024

Structural materials are used extensively in nature where mechanical function is required. These structures are composites consisting of soft and, in some cases, hard phases precisely distributed over different length scales. Bio-inspirati…

Multi-scale and multi-modal imaging study of mantle xenoliths and petrological implications Open

Marco Venier, Luca Ziberna, Lucia Mancini, Alexander P. Kao, Federico Bernardini , et al. · 2023

The accurate textural characterization of mantle xenoliths is one of the fundamental steps to understanding the main processes occurring in the upper mantle, such as sub-solidus recrystallization, magmatic crystallization, and metasomatism…

Effect of radiation-induced damage of trabecular bone tissue evaluated using indentation and digital volume correlation Open

Aikaterina Karali, Enrico Dall’Ara, Jurgita Zekonyte, Alexander P. Kao, Gordon Blunn , et al. · 2022

Exposure to X-ray radiation for an extended amount of time can cause damage to the bone tissue and therefore affect its mechanical properties. Specifically, high-resolution X-ray Computed Tomography (XCT), in both synchrotron and lab-based…

P2X7 Purinoceptor Affects Ectopic Calcification of Dystrophic Muscles Open

Robin M. H. Rumney, Justyna Róg, Natalia Chira, Alexander P. Kao, Rasha Al-Khalidi , et al. · 2022

Ectopic calcification (EC) of myofibers is a pathological feature of muscle damage in Duchenne muscular dystrophy (DMD). Mineralisation of muscle tissue occurs concomitantly with macrophage infiltration, suggesting a link between ectopic m…

Biomimetic generation of the strongest known biomaterial found in limpet tooth Open

Robin M. H. Rumney, Samuel C. Robson, Alexander P. Kao, Eugen Barbu, Łukasz Bożycki , et al. · 2022

The biomaterial with the highest known tensile strength is a unique composite of chitin and goethite (α-FeO(OH)) present in teeth from the Common Limpet ( Patella vulgata ). A biomimetic based on limpet tooth, with corresponding high-perfo…

Baseline Quality-of-Life of Caregivers of Patients With Heart Failure Prior to Advanced Therapies: Findings From the Sustaining Quality of Life of the Aged: Transplant or Mechanical Support (SUSTAIN-IT) Study Open

Michael Petty, Tingqing Wu, Adin‐Cristian Andrei, Abigail S. Baldridge, Anna Warzecha , et al. · 2022

Cover Feature: Insight into the Cycling Behaviour of Metal Anodes, Enabled by X‐ray Tomography and Mathematical Modelling (ChemElectroChem 9/2022) Open

Francesca Rossi, Lucia Mancini, Ivonne Sgura, Marco Boniardi, Andrea Casaroli , et al. · 2022

The Cover Feature illustrates how the combination of electrochemical testing, mathematical modelling and X-ray micro-computed tomography enables the rational design of additives for dendrite-suppression in batteries with Zn anodes. More in…

Dental cementum virtual histology of Neanderthal teeth from Krapina (Croatia, 130–120 kyr): an informed estimate of age, sex and adult stressors Open

Paola Cerrito, Alessia Nava, Davorka Radovčić, Dušan Borić, Leonardo Cerrito , et al. · 2022

The evolution of modern human reproductive scheduling is an aspect of our life history that remains vastly uncomprehended. The present work aims to address this gap by validating a non-destructive cutting-edge methodology to infer adult li…

Insight into the Cycling Behaviour of Metal Anodes, Enabled by X‐ray Tomography and Mathematical Modelling Open

Francesca Rossi, Lucia Mancini, Ivonne Sgura, Marco Boniardi, Andrea Casaroli , et al. · 2022

This work tackles the methodological challenge of rationalizing symmetric‐cell cycling data from a materials‐science perspective, through experiment replication, mathematical modelling, and tomographic imaging. Specifically, we address Zn …

Time-resolved in situ synchrotron-microCT: 4D deformation of bone and bone analogues using digital volume correlation Open

Marta Peña Fernández, Alexander P. Kao, Roxane Bonithon, David Howells, Andrew J. Bodey , et al. · 2021

Novel Insight into the Intricate Shape of Flax Fibre Lumen Open

Emmanuelle Richely, Sylvie Durand, Alessia Melelli, Alexander P. Kao, Anthony Magueresse , et al. · 2021

Plant fibres and especially flax can be distinguished from most synthetic fibres by their intricate shape and intrinsic porosity called lumen, which is usually assumed to be tubular. However, the real shape appears more complex and thus mi…

Multi-scale mechanical and morphological characterisation of sintered porous magnesium-based scaffolds for bone regeneration in critical-sized defects Open

Roxane Bonithon, Alexander P. Kao, Marta Peña Fernández, Joseph Dunlop, Gordon Blunn , et al. · 2021

Helically arranged cross struts in azhdarchid pterosaur cervical vertebrae and their biomechanical implications Open

Cariad J. Williams, Martino Pani, Andrea Bucchi, Roy E. Smith, Alexander P. Kao , et al. · 2021

Biallelic variants in COPB1 cause a novel, severe intellectual disability syndrome with cataracts and variable microcephaly Open

William L. Macken, Annie Godwin, Gabrielle Wheway, Karen Stals, Liliya Nazlamova , et al. · 2021

Micromechanical evaluation of cortical bone using in situ XCT indentation and digital volume correlation Open

Aikaterina Karali, Alexander P. Kao, Jurgita Zekonyte, Gordon Blunn, Gianluca Tozzi · 2020

Low-cycle full-field residual strains in cortical bone and their influence on tissue fracture evaluated via in situ stepwise and continuous X-ray computed tomography Open

Marta Peña Fernández, Alexander P. Kao, Frank Witte, Hari Arora, Gianluca Tozzi · 2020

A long-billed, possible probe-feeding pterosaur (Pterodactyloidea: ?Azhdarchoidea) from the mid-Cretaceous of Morocco, North Africa Open

Roy E. Smith, David M. Martill, Alexander P. Kao, Samir Zouhri, Nicholas R. Longrich · 2020

Full‐field strain of regenerated bone tissue in a femoral fracture model Open

Aikaterina Karali, Alexander P. Kao, Richard Meeson, Marta Roldo, Gordon Blunn , et al. · 2020

Summary The mechanical behaviour of regenerated bone tissue during fracture healing is key in determining its ability to withstand physiological loads. However, the strain distribution in the newly formed tissue and how this influences the…

Full-Field Strain Uncertainties and Residuals at the Cartilage-Bone Interface in Unstained Tissues Using Propagation-Based Phase-Contrast XCT and Digital Volume Correlation Open

Gianluca Tozzi, Marta Peña Fernández, Sarah Davis, Aikaterina Karali, Alexander P. Kao , et al. · 2020

A deeper understanding of the cartilage-bone mechanics is fundamental to unravel onset and progression of osteoarthritis, enabling better diagnosis and treatment. The aim of this study is therefore to explore the capability of X-ray comput…

A new tapejarid (Pterosauria, Azhdarchoidea) from the mid-Cretaceous Kem Kem beds of Takmout, southern Morocco Open

David M. Martill, Roy E. Smith, David M. Unwin, Alexander P. Kao, James McPhee , et al. · 2020

In vivo delivery of VEGF RNA and protein to increase osteogenesis and intraosseous angiogenesis Open

Robin M. H. Rumney, Stuart Lanham, Janos M. Kanczler, Alexander P. Kao, Lalitha Thiagarajan , et al. · 2019

Antibacterial PMMA Composite Cements with Tunable Thermal and Mechanical Properties Open

Arianna De Mori, Emanuela Di Gregorio, Alexander P. Kao, Gianluca Tozzi, Eugen Barbu , et al. · 2019

PMMA-based cements are the most used bone cements in vertebroplasty and total hip arthroplasty. However, they present several drawbacks, including susceptibility to bacterial infection, monomer leakage toxicity, and high polymerization tem…

Hierarchical electrospun tendon‐ligament bioinspired scaffolds induce changes in fibroblasts morphology under static and dynamic conditions Open

Alberto Sensini, Luca Cristofolini, Andrea Zucchelli, Maria Letizia Focarete, Chiara Gualandi , et al. · 2019

Summary The regeneration of injured tendons and ligaments is challenging because the scaffolds needs proper mechanical properties and a biomimetic morphology. In particular, the morphological arrangement of scaffolds is a key point to driv…

Morphologically bioinspired hierarchical nylon 6,6 electrospun assembly recreating the structure and performance of tendons and ligaments Open

Alberto Sensini, Carlo Gotti, Juri Belcari, Andrea Zucchelli, Maria Letizia Focarete , et al. · 2019

Multiscale hierarchical bioresorbable scaffolds for the regeneration of tendons and ligaments Open

Alberto Sensini, Chiara Gualandi, Maria Letizia Focarete, Juri Belcari, Andrea Zucchelli , et al. · 2019

Lesions of tendons and ligaments account for over 40% of the musculoskeletal lesions. Surgical techniques and materials for repair and regeneration are currently not satisfactory. The high rate of post-operative complications and failures …

Evaluation of X‐ray tomography contrast agents: A review of production, protocols, and biological applications Open

Mümin Mehmet Koç, Naim Aslan, Alexander P. Kao, Asa H. Barber · 2019

X‐ray computed tomography is a strong tool that finds many applications both in medical applications and in the investigation of biological and nonbiological samples. In the clinics, X‐ray tomography is widely used for diagnostic purposes …

Tendon Fascicle-Inspired Nanofibrous Scaffold of Polylactic acid/Collagen with Enhanced 3D-Structure and Biomechanical Properties Open

Alberto Sensini, Chiara Gualandi, Andrea Zucchelli, Liam A. Boyle, Alexander P. Kao , et al. · 2018

Preservation of Bone Tissue Integrity with Temperature Control for In Situ SR-MicroCT Experiments Open

Marta Peña Fernández, Enrico Dall’Ara, Alexander P. Kao, Andrew J. Bodey, Aikaterina Karali , et al. · 2018

Digital volume correlation (DVC), combined with in situ synchrotron microcomputed tomography (SR-microCT) mechanics, allows for 3D full-field strain measurement in bone at the tissue level. However, long exposures to SR radiation are known…

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