Alexander P. Sobinoff
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View article: Potent synthetic lethality between PLK1 and EYA family inhibitors in tumors of the central and peripheral nervous systems
Potent synthetic lethality between PLK1 and EYA family inhibitors in tumors of the central and peripheral nervous systems Open
The Eyes Absent family of protein phosphatases (EYA1–4) is aberrantly expressed and tumor-promoting across many devastating cancers of neurological origin affecting both children and adults. It has recently been demonstrated that EYA1 and …
View article: NONO, SFPQ, and PSPC1 promote telomerase recruitment to the telomere
NONO, SFPQ, and PSPC1 promote telomerase recruitment to the telomere Open
Telomerase is a ribonucleoprotein enzyme that maintains telomeric repeats on chromosome ends in continuously dividing cells. Telomere maintenance via telomerase is dependent on the correct assembly of the enzyme complex, complex stabilizat…
View article: Xenobiotics; effects on female fertility
Xenobiotics; effects on female fertility Open
Over the course of the 20th century there has been an increasing trend in western women opting to delay childbirth in the pursuit of social and economic stability. This development has highlighted the need to identify and characterise ovot…
View article: Telomere length in offspring is determined by mitochondrial-nuclear communication at fertilization
Telomere length in offspring is determined by mitochondrial-nuclear communication at fertilization Open
View article: Potent synthetic lethality between PLK1 and EYA-family inhibitors in tumours of the central and peripheral nervous system
Potent synthetic lethality between PLK1 and EYA-family inhibitors in tumours of the central and peripheral nervous system Open
The Eyes Absent family of protein phosphatases (EYA1-4) are aberrantly expressed and tumour-promoting across many devastating cancers of neurological origin affecting both children and adults. It has recently been demonstrated that EYA1 an…
View article: Mechanism of structure-specific DNA binding by the FANCM branchpoint translocase
Mechanism of structure-specific DNA binding by the FANCM branchpoint translocase Open
FANCM is a DNA repair protein that recognizes stalled replication forks, and recruits downstream repair factors. FANCM activity is also essential for the survival of cancer cells that utilize the Alternative Lengthening of Telomeres (ALT) …
View article: Mechanism of structure-specific DNA binding by the FANCM branchpoint translocase
Mechanism of structure-specific DNA binding by the FANCM branchpoint translocase Open
FANCM is a DNA repair protein that recognizes stalled replication forks, and recruits downstream repair factors. FANCM activity is also essential for the survival of cancer cells that utilize the Alternative Lengthening of Telomeres (ALT) …
View article: ZNF827 is a single-stranded DNA binding protein that regulates the ATR-CHK1 DNA damage response pathway
ZNF827 is a single-stranded DNA binding protein that regulates the ATR-CHK1 DNA damage response pathway Open
View article: The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation
The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation Open
The Eyes Absent proteins (EYA1-4) are a biochemically unique group of tyrosine phosphatases known to be tumour-promoting across a range of cancer types. To date, the targets of EYA phosphatase activity remain largely uncharacterised. Here,…
View article: Distinct modes of telomere synthesis and extension contribute to Alternative Lengthening of Telomeres
Distinct modes of telomere synthesis and extension contribute to Alternative Lengthening of Telomeres Open
View article: Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia
Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia Open
View article: Imetelstat-Mediated Alterations in Fatty Acid Metabolism To Induce Ferroptosis As Therapeutic Strategy for Acute Myeloid Leukemia
Imetelstat-Mediated Alterations in Fatty Acid Metabolism To Induce Ferroptosis As Therapeutic Strategy for Acute Myeloid Leukemia Open
Telomerase enables replicative immortality in most cancers including acute myeloid leukemia (AML). Imetelstat is a first-in-class telomerase inhibitor with clinical efficacy in myelofibrosis and myelodysplastic syndromes. Here, we develop …
View article: Irreversible inhibition of TRF2<sub>TRFH</sub>recruiting functions: a strategy to induce telomeric replication stress in cancer cells
Irreversible inhibition of TRF2<sub>TRFH</sub>recruiting functions: a strategy to induce telomeric replication stress in cancer cells Open
The shelterin component telomeric repeat-binding factor 2 (TRF2) is an essential regulator of telomere homeostasis and genomic stability. Mutations in the TRF2 TRFH domain physically impair t-loop formation and prevent the recruitment of s…
View article: The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation
The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation Open
The Eyes Absent family of proteins (EYA1-4) are a biochemically unique group of tyrosine phosphatases known to be tumour promoting across a range of cancer types. To date, the molecular targets of EYA phosphatase activity remain largely un…
View article: <scp>TOP3A</scp> amplification and <scp>ATRX</scp> inactivation are mutually exclusive events in pediatric osteosarcomas using <scp>ALT</scp>
<span>TOP3A</span> amplification and <span>ATRX</span> inactivation are mutually exclusive events in pediatric osteosarcomas using <span>ALT</span> Open
In some types of cancer, telomere length is maintained by the alternative lengthening of telomeres (ALT) mechanism. In many ALT cancers, the α-thalassemia/mental retardation syndrome X-linked (ATRX) gene is mutated leading to the conclusio…
View article: Telomere Length Measurement by Molecular Combing
Telomere Length Measurement by Molecular Combing Open
Telomeres are repetitive regions of DNA bound by specialized proteins at the termini of linear chromosomes that prevent the natural chromosome ends from being recognized as DNA double strand breaks. Telomeric DNA is gradually eroded with e…
View article: Author Correction: The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)
Author Correction: The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT) Open
View article: Telomerase promotes formation of a telomere protective complex in cancer cells
Telomerase promotes formation of a telomere protective complex in cancer cells Open
The telomerase protein hTERT has a noncanonical role in promoting telomere protection by heat shock protein 70.
View article: The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)
The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT) Open
View article: BLM and SLX4 play opposing roles in recombination‐dependent replication at human telomeres
BLM and SLX4 play opposing roles in recombination‐dependent replication at human telomeres Open
View article: Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres
Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres Open
Acquisition of replicative immortality is currently regarded as essential for malignant transformation. This is achieved by activating a telomere lengthening mechanism (TLM), either telomerase or alternative lengthening of telomeres, to co…
View article: Maternal Smoke Exposure Impairs the Long-Term Fertility of Female Offspring in a Murine Model1
Maternal Smoke Exposure Impairs the Long-Term Fertility of Female Offspring in a Murine Model1 Open
The theory of fetal origins of adult disease was first proposed in 1989, and in the decades since, a wide range of other diseases from obesity to asthma have been found to originate in early development. Because mammalian oocyte developmen…
View article: Knockout of RNA Binding Protein MSI2 Impairs Follicle Development in the Mouse Ovary: Characterization of MSI1 and MSI2 during Folliculogenesis
Knockout of RNA Binding Protein MSI2 Impairs Follicle Development in the Mouse Ovary: Characterization of MSI1 and MSI2 during Folliculogenesis Open
Characterizing the mechanisms underlying follicle development in the ovary is crucial to understanding female fertility and is an area of increasing research interest. The RNA binding protein Musashi is essential for post-transcriptional r…
View article: A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase
A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase Open
The TERT-CLPTM1L region of chromosome 5p15.33 is a multi-cancer susceptibility locus that encodes the reverse transcriptase subunit, hTERT, of the telomerase enzyme. Numerous cancer-associated single-nucleotide polymorphisms (SNPs), includ…