Alexander Perfilyev
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View article: Epigenetic biomarkers predict macrovascular events in individuals with type 2 diabetes
Epigenetic biomarkers predict macrovascular events in individuals with type 2 diabetes Open
Prediction of incident macrovascular events (iMEs) in individuals with type 2 diabetes (T2D) remains suboptimal. We aim to discover blood-based epigenetic biomarkers predicting iMEs in 752 newly diagnosed individuals with T2D, among whom 1…
View article: Insulin levels at 18–20 gestational weeks in pregnant women with obesity are associated with newborn abdominal fat deposition and DNA methylation in cord blood
Insulin levels at 18–20 gestational weeks in pregnant women with obesity are associated with newborn abdominal fat deposition and DNA methylation in cord blood Open
We assessed if fasting plasma insulin levels in pregnant women with obesity are associated with newborns’ abdominal fat deposition (dual-energy X-ray absorptiometry) and with cord blood DNA methylation (450k array) in 232 mother–child pair…
View article: Hidden in plain sight: Bacterial genomes reveal thousands of lytic phages with therapeutic potential
Hidden in plain sight: Bacterial genomes reveal thousands of lytic phages with therapeutic potential Open
Phages are typically classified as temperate, integrating into host genomes, or lytic, replicating and killing bacteria. Lytic phages are not expected in bacterial genome sequences, yet our analysis of 3.6 million bacterial assemblies from…
View article: Blood-Based Epigenetic Biomarkers Associated With Incident Chronic Kidney Disease in Individuals With Type 2 Diabetes
Blood-Based Epigenetic Biomarkers Associated With Incident Chronic Kidney Disease in Individuals With Type 2 Diabetes Open
There is an increasing need for new biomarkers to improve prediction of chronic kidney disease (CKD) in individuals with type 2 diabetes (T2D). We aimed to identify blood-based epigenetic biomarkers associated with incident CKD and develop…
View article: Blood-based epigenetic biomarkers associated with incident chronic kidney disease in individuals with type 2 diabetes
Blood-based epigenetic biomarkers associated with incident chronic kidney disease in individuals with type 2 diabetes Open
There is an increasing need for new biomarkers improving prediction of chronic kidney disease (CKD) in individuals with type 2 diabetes (T2D). We aimed to identify blood-based epigenetic biomarkers associated with incident CKD and develop …
View article: Blood-based epigenetic biomarkers associated with incident chronic kidney disease in individuals with type 2 diabetes
Blood-based epigenetic biomarkers associated with incident chronic kidney disease in individuals with type 2 diabetes Open
There is an increasing need for new biomarkers improving prediction of chronic kidney disease (CKD) in individuals with type 2 diabetes (T2D). We aimed to identify blood-based epigenetic biomarkers associated with incident CKD and develop …
View article: Impact of excess sugar on the whole genome DNA methylation pattern in human sperm
Impact of excess sugar on the whole genome DNA methylation pattern in human sperm Open
In human sperm, DNA methylation levels were linked to gene expression, and excess sugar had modest effects on methylation on imprinted and highly expressed genes, and genes affecting fertility.
View article: <scp>D</scp><scp>NA</scp> methylation in cord blood partially mediates the effects of prepregnancy <scp>BMI</scp> on early childhood offspring <scp>BMI</scp>
<span>D</span><span>NA</span> methylation in cord blood partially mediates the effects of prepregnancy <span>BMI</span> on early childhood offspring <span>BMI</span> Open
Objective We investigated whether prepregnancy BMI (prePregBMI) in women with obesity was associated with differential DNA methylation (DNAm) in cord blood (CB) and whether DNAm may mediate the association of prePregBMI and early childhood…
View article: Multiomics profiling of DNA methylation, microRNA, and mRNA in skeletal muscle from monozygotic twin pairs discordant for type 2 diabetes identifies dysregulated genes controlling metabolism
Multiomics profiling of DNA methylation, microRNA, and mRNA in skeletal muscle from monozygotic twin pairs discordant for type 2 diabetes identifies dysregulated genes controlling metabolism Open
View article: Predicting type 2 diabetes via machine learning integration of multiple omics from human pancreatic islets
Predicting type 2 diabetes via machine learning integration of multiple omics from human pancreatic islets Open
Type 2 diabetes (T2D) is the fastest growing non-infectious disease worldwide. Impaired insulin secretion from pancreatic beta-cells is a hallmark of T2D, but the mechanisms behind this defect are insufficiently characterized. Integrating …
View article: Genes with epigenetic alterations in human pancreatic islets impact mitochondrial function, insulin secretion, and type 2 diabetes
Genes with epigenetic alterations in human pancreatic islets impact mitochondrial function, insulin secretion, and type 2 diabetes Open
Epigenetic dysregulation may influence disease progression. Here we explore whether epigenetic alterations in human pancreatic islets impact insulin secretion and type 2 diabetes (T2D). In islets, 5,584 DNA methylation sites exhibit altera…
View article: DNA methylation partially mediates antidiabetic effects of metformin on HbA1c levels in individuals with type 2 diabetes
DNA methylation partially mediates antidiabetic effects of metformin on HbA1c levels in individuals with type 2 diabetes Open
Metformin-associated alterations in DNA methylation partially mediates metformin's antidiabetic effects on HbA1c in newly-diagnosed individuals with type 2 diabetes.
View article: Gestational weight gain in pregnant women with obesity is associated with cord blood DNA methylation, which partially mediates offspring anthropometrics
Gestational weight gain in pregnant women with obesity is associated with cord blood DNA methylation, which partially mediates offspring anthropometrics Open
Obesity and excessive gestational weight gain (GWG) influence the offspring's future health, and DNA methylation, an epigenetic mark occurring on CpG sites, constitutes a potential mechanism underlying this relationship.1, 2 GWG has been a…
View article: Liver saturated fat content associates with hepatic DNA methylation in obese individuals
Liver saturated fat content associates with hepatic DNA methylation in obese individuals Open
Background Accumulation of saturated fatty acids (SFAs) in the liver is known to induce hepatic steatosis and inflammation causing non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Although SFAs have been …
View article: Circulating triglycerides are associated with human adipose tissue DNA methylation of genes linked to metabolic disease
Circulating triglycerides are associated with human adipose tissue DNA methylation of genes linked to metabolic disease Open
Dysregulation of circulating lipids is a central element for the metabolic syndrome. However, it is not well established whether human subcutaneous adipose tissue is affected by or affect circulating lipids through epigenetic mechanisms. H…
View article: Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets
Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets Open
Type 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic β cells. To identify candidate genes contributing to T2D pathophysiology, we studied human pancreatic islets from approximately 300 individuals. We found 395…
View article: Glucocorticoids and glucolipotoxicity alter the DNA methylome and function of human EndoC-βH1 cells
Glucocorticoids and glucolipotoxicity alter the DNA methylome and function of human EndoC-βH1 cells Open
DEX treatment and glucolipotoxic conditions separately alter the β-cell epigenome and function. The combination of both treatments exacerbates these changes, showing that caution is needed when prescribing potent glucocorticoids in patient…
View article: Novel Subgroups of Type 2 Diabetes Display Different Epigenetic Patterns That Associate With Future Diabetic Complications
Novel Subgroups of Type 2 Diabetes Display Different Epigenetic Patterns That Associate With Future Diabetic Complications Open
OBJECTIVE Type 2 diabetes (T2D) was recently reclassified into severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD), and mild age-related diabetes (MARD), which have differ…
View article: Novel subgroups of type 2 diabetes display different epigenetic patterns which associate with future diabetic complications
Novel subgroups of type 2 diabetes display different epigenetic patterns which associate with future diabetic complications Open
Objective: Type 2 diabetes (T2D) was recently reclassified into Severe Insulin Deficient Diabetes (SIDD), Severe Insulin Resistant Diabetes (SIRD), Mild Obesity-related Diabetes (MOD), and Mild Age-Related Diabetes (MARD),…
View article: Novel subgroups of type 2 diabetes display different epigenetic patterns which associate with future diabetic complications
Novel subgroups of type 2 diabetes display different epigenetic patterns which associate with future diabetic complications Open
Objective: Type 2 diabetes (T2D) was recently reclassified into Severe Insulin Deficient Diabetes (SIDD), Severe Insulin Resistant Diabetes (SIRD), Mild Obesity-related Diabetes (MOD), and Mild Age-Related Diabetes (MARD),…
View article: Differential DNA Methylation and Expression of MicroRNAs in Adipose Tissue from Twin Pairs Discordant for Type 2 Diabetes
Differential DNA Methylation and Expression of MicroRNAs in Adipose Tissue from Twin Pairs Discordant for Type 2 Diabetes Open
The prevalence of type 2 diabetes (T2D) is increasing worldwide but current treatments have limitations. MicroRNAs (miRNAs) may play a key role in the development of T2D and can be targets for novel therapies. Here, we examined whether T2D…
View article: Differential DNA Methylation and Expression of miRNAs in Adipose Tissue From Twin Pairs Discordant for Type 2 Diabetes
Differential DNA Methylation and Expression of miRNAs in Adipose Tissue From Twin Pairs Discordant for Type 2 Diabetes Open
The prevalence of type 2 diabetes (T2D) is increasing worldwide, but current treatments have limitations. miRNAs may play a key role in the development of T2D and can be targets for novel therapies. Here, we examined whether T2D is associa…
View article: Differential DNA Methylation and Expression of MicroRNAs in Adipose Tissue from Twin Pairs Discordant for Type 2 Diabetes
Differential DNA Methylation and Expression of MicroRNAs in Adipose Tissue from Twin Pairs Discordant for Type 2 Diabetes Open
The prevalence of type 2 diabetes (T2D) is increasing worldwide but current treatments have limitations. MicroRNAs (miRNAs) may play a key role in the development of T2D and can be targets for novel therapies. Here, we examined whether T2D…
View article: Statin therapy is associated with epigenetic modifications in individuals with Type 2 diabetes
Statin therapy is associated with epigenetic modifications in individuals with Type 2 diabetes Open
Aim: Statins lower cholesterol and reduce the risk of cardiovascular disease. However, the exact mechanisms of statins remain unknown. We investigated whether statin therapy associates with epigenetics in Type 2 diabetes (T2D) patie…
View article: VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics
VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics Open
View article: Lifestyle Intervention in Pregnant Women With Obesity Impacts Cord Blood DNA Methylation Which Associates With Body Composition in the Offspring
Lifestyle Intervention in Pregnant Women With Obesity Impacts Cord Blood DNA Methylation Which Associates With Body Composition in the Offspring Open
Maternal obesity may lead to epigenetic alterations in the offspring and might thereby contribute to disease later in life. We investigated whether a lifestyle intervention in pregnant women with obesity is associated with epigenetic varia…
View article: Lifestyle Intervention in Pregnant Women With Obesity Impacts Cord Blood DNA Methylation Which Associates With Body Composition in the Offspring
Lifestyle Intervention in Pregnant Women With Obesity Impacts Cord Blood DNA Methylation Which Associates With Body Composition in the Offspring Open
Maternal obesity may lead to epigenetic alterations in the offspring and might thereby contribute to disease later in life. We investigated whether a lifestyle intervention in pregnant women with obesity is associated with epigenetic varia…
View article: Lifestyle Intervention in Pregnant Women With Obesity Impacts Cord Blood DNA Methylation, Which Associates With Body Composition in the Offspring
Lifestyle Intervention in Pregnant Women With Obesity Impacts Cord Blood DNA Methylation, Which Associates With Body Composition in the Offspring Open
Maternal obesity may lead to epigenetic alterations in the offspring and might thereby contribute to disease later in life. We investigated whether a lifestyle intervention in pregnant women with obesity is associated with epigenetic varia…
View article: Lifestyle Intervention in Pregnant Women With Obesity Impacts Cord Blood DNA Methylation Which Associates With Body Composition in the Offspring
Lifestyle Intervention in Pregnant Women With Obesity Impacts Cord Blood DNA Methylation Which Associates With Body Composition in the Offspring Open
Maternal obesity may lead to epigenetic alterations in the offspring and might thereby contribute to disease later in life. We investigated whether a lifestyle intervention in pregnant women with obesity is associated with epigenetic varia…
View article: Serum aromatic and branched‐chain amino acids associated with NASH demonstrate divergent associations with serum lipids
Serum aromatic and branched‐chain amino acids associated with NASH demonstrate divergent associations with serum lipids Open
Background & Aims Non‐alcoholic fatty liver disease (NAFLD) has been associated with multiple metabolic abnormalities. By applying a non‐targeted metabolomics approach, we aimed at investigating whether serum metabolite profile that associ…