Alexander R. Moise
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View article: A secreted Tapasin isoform impairs cytotoxic T lymphocyte recognition by disrupting exogenous MHC class I antigen presentation
A secreted Tapasin isoform impairs cytotoxic T lymphocyte recognition by disrupting exogenous MHC class I antigen presentation Open
Endogenous and exogenous antigen processing and presentation through the MHC class I peptide-loading complex (PLC) are essential for initiating cytotoxic T lymphocyte responses against pathogens and tumors. Tapasin, a key component of the …
View article: Identification and characterization of short-chain dehydrogenase/reductase 3 (DHRS3) deficiency, a retinoic acid embryopathy of humans
Identification and characterization of short-chain dehydrogenase/reductase 3 (DHRS3) deficiency, a retinoic acid embryopathy of humans Open
View article: Feedback regulation of retinaldehyde reductase <scp>DHRS3</scp> , a critical determinant of retinoic acid homeostasis
Feedback regulation of retinaldehyde reductase <span>DHRS3</span> , a critical determinant of retinoic acid homeostasis Open
Retinoic acid is crucial for vertebrate embryogenesis, influencing anterior‐posterior patterning and organogenesis through its interaction with nuclear hormone receptors comprising heterodimers of retinoic acid receptors (RARα, β, or γ) an…
View article: Regenerating Skeletal Muscle Compensates for the Impaired Macrophage Functions Leading to Normal Muscle Repair in Retinol Saturase Null Mice
Regenerating Skeletal Muscle Compensates for the Impaired Macrophage Functions Leading to Normal Muscle Repair in Retinol Saturase Null Mice Open
Skeletal muscle repair is initiated by local inflammation and involves the engulfment of dead cells (efferocytosis) by infiltrating macrophages at the injury site. Macrophages orchestrate the whole repair program, and efferocytosis is a ke…
View article: Mechanisms of Feedback Regulation of Vitamin A Metabolism
Mechanisms of Feedback Regulation of Vitamin A Metabolism Open
Vitamin A is an essential nutrient required throughout life. Through its various metabolites, vitamin A sustains fetal development, immunity, vision, and the maintenance, regulation, and repair of adult tissues. Abnormal tissue levels of t…
View article: Role of cellular retinol‐binding protein, type 1 and retinoid homeostasis in the adult mouse heart: A multi‐omic approach
Role of cellular retinol‐binding protein, type 1 and retinoid homeostasis in the adult mouse heart: A multi‐omic approach Open
The main active metabolite of Vitamin A, all ‐ trans retinoic acid (RA), is required for proper cellular function and tissue organization. Heart development has a well‐defined requirement for RA, but there is limited research on the role o…
View article: Carotenoid modifying enzymes in metazoans
Carotenoid modifying enzymes in metazoans Open
View article: Expression and biochemical analyses of proteins involved in the transport of carotenoids and retinoids
Expression and biochemical analyses of proteins involved in the transport of carotenoids and retinoids Open
View article: Multi-omic Analysis of Non-human Primate Heart after Partial-body Radiation with Minimal Bone Marrow Sparing
Multi-omic Analysis of Non-human Primate Heart after Partial-body Radiation with Minimal Bone Marrow Sparing Open
High-dose radiation exposure results in hematopoietic and gastrointestinal acute radiation syndromes followed by delayed effects of acute radiation exposure, which encompasses multiple organs, including heart, kidney, and lung. Here we sou…
View article: A retrospective cohort study evaluating correlates of deep tissue infections among patients enrolled in opioid agonist treatment using administrative data in Ontario, Canada
A retrospective cohort study evaluating correlates of deep tissue infections among patients enrolled in opioid agonist treatment using administrative data in Ontario, Canada Open
The study indicates factors that are associated with deep tissue infections in the opioid use disorder population and can be used to identify opportunities to reduce the incidence of new infections.
View article: Role of carotenoids and retinoids during heart development
Role of carotenoids and retinoids during heart development Open
View article: Identifying vitamin A signaling by visualizing gene and protein activity, and by quantification of vitamin A metabolites
Identifying vitamin A signaling by visualizing gene and protein activity, and by quantification of vitamin A metabolites Open
View article: Retinol Saturase Knock-Out Mice are Characterized by Impaired Clearance of Apoptotic Cells and Develop Mild Autoimmunity
Retinol Saturase Knock-Out Mice are Characterized by Impaired Clearance of Apoptotic Cells and Develop Mild Autoimmunity Open
Apoptosis and the proper clearance of apoptotic cells play a central role in maintaining tissue homeostasis. Previous work in our laboratory has shown that when a high number of cells enters apoptosis in a tissue, the macrophages that engu…
View article: Modulation of retinoid signaling: therapeutic opportunities in organ fibrosis and repair
Modulation of retinoid signaling: therapeutic opportunities in organ fibrosis and repair Open
View article: Recent insights on the role and regulation of retinoic acid signaling during epicardial development
Recent insights on the role and regulation of retinoic acid signaling during epicardial development Open
The vitamin A metabolite, retinoic acid, carries out essential and conserved roles in vertebrate heart development. Retinoic acid signals via retinoic acid receptors (RAR)/retinoid X receptors (RXRs) heterodimers to induce the expression o…
View article: Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development
Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development Open
View article: Retinol saturase modulates lipid metabolism and the production of reactive oxygen species
Retinol saturase modulates lipid metabolism and the production of reactive oxygen species Open
View article: New insights and changing paradigms in the regulation of vitamin A metabolism in development
New insights and changing paradigms in the regulation of vitamin A metabolism in development Open
Vitamin A and its active metabolite retinoic acid are essential for embryonic development and adult homeostasis. Surprisingly, excess or deficiency of vitamin A and retinoic acid can cause similar developmental defects. Therefore, strict f…