Alexander R. Stainer
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View article: Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability
Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability Open
View article: 1,8-Cineole Affects Agonists-Induced Platelet Activation, Thrombus Formation and Haemostasis
1,8-Cineole Affects Agonists-Induced Platelet Activation, Thrombus Formation and Haemostasis Open
1,8-cineole, a monoterpenoid is a major component of eucalyptus oil and has been proven to possess numerous beneficial effects in humans. Notably, 1,8-cineole is the primary active ingredient of a clinically approved drug, Soledum® which i…
View article: Structural, functional, and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets
Structural, functional, and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets Open
Connexins oligomerise to form hexameric hemichannels in the plasma membrane that can further dock together on adjacent cells to form gap junctions and facilitate intercellular trafficking of molecules. In this study, we report the expressi…
View article: Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling
Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling Open
Pim kinases are upregulated in several forms of cancer, contributing to cell survival and tumour development, but their role in platelet function and thrombotic disease has not been explored. We report for the first time that Pim-1 is expr…
View article: Non-genomic effects of the Pregnane X Receptor negatively regulate GPVI-mediated platelet signalling
Non-genomic effects of the Pregnane X Receptor negatively regulate GPVI-mediated platelet signalling Open
The pregnane X receptor (PXR) is a nuclear receptor (NR), involved in the detoxification of xenobiotic compounds. Recently, its presence was reported in the human vasculature and its ligands were proposed to exhibit anti-atherosclerotic ef…
View article: Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasis
Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasis Open
View article: The Metabolites of the Dietary Flavonoid Quercetin Possess Potent Antithrombotic Activity, and Interact with Aspirin to Enhance Antiplatelet Effects
The Metabolites of the Dietary Flavonoid Quercetin Possess Potent Antithrombotic Activity, and Interact with Aspirin to Enhance Antiplatelet Effects Open
Quercetin, a dietary flavonoid, has been reported to possess antiplatelet activity. However, its extensive metabolism following ingestion has resulted in difficulty elucidating precise mechanisms of action. In this study, we aimed to chara…
View article: A humanized monoclonal antibody that inhibits platelet‐surface ERp72 reveals a role for ERp72 in thrombosis
A humanized monoclonal antibody that inhibits platelet‐surface ERp72 reveals a role for ERp72 in thrombosis Open
Background Within the endoplasmic reticulum, thiol isomerase enzymes modulate the formation and rearrangement of disulfide bonds in newly folded proteins entering the secretory pathway to ensure correct protein folding. In addition to thei…
View article: Role of flavonoids and nitrates in cardiovascular health
Role of flavonoids and nitrates in cardiovascular health Open
CVD remain the leading cause of death globally. Effective dietary strategies for their reduction are of high priority. Increasing evidence suggests that phytochemicals, particularly dietary flavonoids and nitrates, are key modulators of CV…
View article: Ibrutinib Inhibits Platelet Integrin α <sub>IIb</sub> β <sub>3</sub> Outside-In Signaling and Thrombus Stability But Not Adhesion to Collagen
Ibrutinib Inhibits Platelet Integrin α <sub>IIb</sub> β <sub>3</sub> Outside-In Signaling and Thrombus Stability But Not Adhesion to Collagen Open
Objective— Ibrutinib is an irreversible Bruton tyrosine kinase inhibitor approved for treatment of Waldenstrom macroglobulinemia, chronic lymphocytic leukemia, and mantle cell lymphoma that increases the risk of bleeding among patients. Pl…
View article: Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions
Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions Open
A well-known histopathological feature of diseased skin in Buruli ulcer (BU) is coagulative necrosis caused by the Mycobacterium ulcerans macrolide exotoxin mycolactone. Since the underlying mechanism is not known, we have investiga…
View article: Pharmacological actions of nobiletin in the modulation of platelet function
Pharmacological actions of nobiletin in the modulation of platelet function Open
Background and Purpose The discovery that flavonoids are capable of inhibiting platelet function has led to their investigation as potential antithrombotic agents. However, despite the range of studies on the antiplatelet properties of fla…