Alexander Rühle
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View article: Patterns of lymphatic spread in hypopharyngeal squamous cell carcinoma – Findings from a multicenter study
Patterns of lymphatic spread in hypopharyngeal squamous cell carcinoma – Findings from a multicenter study Open
We provide detailed information about lymphatic spread patterns of hypopharyngeal SCC, where subgroups of patients may be identified in whom the ENI may be reduced. For lateralized tumors, contralateral irradiation may be limited to LNL II…
View article: Impact of target volume and dose concepts on the outcomes of prostate cancer patients treated with stereotactic body radiotherapy for spinal metastases − a European multicenter cohort study
Impact of target volume and dose concepts on the outcomes of prostate cancer patients treated with stereotactic body radiotherapy for spinal metastases − a European multicenter cohort study Open
This multicenter cohort analysis showed that SBRT of spine BoM from prostate cancer is an effective and well-tolerated treatment. Both BED and usage of a SIB concept were associated with improved PFS and BRFS. Prospective studies are neede…
View article: Challenges in recurrent head and neck squamous cell cancer treatment: systematic review and meta-analysis comparing efficacy and toxicity between post-operative and definitive IMRT-based reirradiation
Challenges in recurrent head and neck squamous cell cancer treatment: systematic review and meta-analysis comparing efficacy and toxicity between post-operative and definitive IMRT-based reirradiation Open
View article: Quality of life following total neoadjuvant therapy for rectal cancer
Quality of life following total neoadjuvant therapy for rectal cancer Open
Purpose This study aimed to assess the health-related quality of life (HRQoL) in patients with locally advanced rectal cancer (LARC) undergoing total neoadjuvant therapy (TNT), comparing outcomes with the German general population and colo…
View article: A multi-institutional dataset on patient-individual lymph node involvement in hypopharyngeal and laryngeal squamous cell carcinoma
A multi-institutional dataset on patient-individual lymph node involvement in hypopharyngeal and laryngeal squamous cell carcinoma Open
View article: Fear of cancer recurrence in adults with p16-positive head and neck cancer after radiotherapy – Results from a multicenter cross-sectional observational study
Fear of cancer recurrence in adults with p16-positive head and neck cancer after radiotherapy – Results from a multicenter cross-sectional observational study Open
Strong FCR affected about one-fifth of p16-positive head and neck cancer survivors and was associated with lower quality of life as well as higher distress, depression, and anxiety.
View article: Dosisreduktion der elektiven Lymphabflussbestrahlung bei Kopf-Hals-Karzinomen: bereit für die klinische Routine?
Dosisreduktion der elektiven Lymphabflussbestrahlung bei Kopf-Hals-Karzinomen: bereit für die klinische Routine? Open
View article: Short-course radiotherapy versus long-course chemoradiotherapy in total neoadjuvant therapy of rectal cancer – A multicenter analysis of early outcomes and toxicity
Short-course radiotherapy versus long-course chemoradiotherapy in total neoadjuvant therapy of rectal cancer – A multicenter analysis of early outcomes and toxicity Open
LCRT was associated with higher CR and NOM rates. Whether it might be preferred over SCRT for intended NOM remains a relevant question to be answered by ongoing randomized trials.
View article: Abscopal effects in patients with malignant melanoma treated with radiotherapy and immune checkpoint inhibition: analysis of a large observational multicenter study
Abscopal effects in patients with malignant melanoma treated with radiotherapy and immune checkpoint inhibition: analysis of a large observational multicenter study Open
Background Abscopal effect (AbE), the regression of non-irradiated metastatic lesions (NILs) following radiotherapy (RT), is relevant in patients with malignant melanoma (MM) with progressive disease (PD) under immune checkpoint inhibition…
View article: Stereotactic body radiotherapy for spine and non-spine bone metastases in prostate carcinoma – a multicenter cohort analysis
Stereotactic body radiotherapy for spine and non-spine bone metastases in prostate carcinoma – a multicenter cohort analysis Open
Bone SBRT for OMPC is an effective treatment with low toxicity and particularly low fracture rates for both spine and non-spine BoM with no difference in outcome based on the localization. Prospective trials will help to identify the patie…
View article: Quality of life in cancer patients at the end of radiotherapy compared to a general population sample in Germany
Quality of life in cancer patients at the end of radiotherapy compared to a general population sample in Germany Open
Germany has one of the highest cancer incidence rates in Europe. Radiotherapy is essential for patients with cancer as 50% have an evidence‐based indication for radiotherapy. However, it is unknown how health‐related quality of life (HRQoL…
View article: Decision regret in patients with head-and-neck cancer undergoing radiotherapy
Decision regret in patients with head-and-neck cancer undergoing radiotherapy Open
View article: Tenth anniversary of the Young DEGRO Team Trial—reflecting on the past, shaping the future
Tenth anniversary of the Young DEGRO Team Trial—reflecting on the past, shaping the future Open
View article: Comparison of survival and progression after focal- or whole brain radiotherapy in patients with primary CNS lymphoma – Results from a large multicenter analysis of the German Society of Radiation Oncology’s Neuro-Radio-Oncology Working Group (DEGRO AG-NRO)
Comparison of survival and progression after focal- or whole brain radiotherapy in patients with primary CNS lymphoma – Results from a large multicenter analysis of the German Society of Radiation Oncology’s Neuro-Radio-Oncology Working Group (DEGRO AG-NRO) Open
fRT may be a beneficial treatment option for patients with PCNSL and needs to be studied further in prospective clinical trials.
View article: Balancing barriers: Family, career, and gender equality in radiation oncology and radiation research—An interdisciplinary prospective survey among the young workforce
Balancing barriers: Family, career, and gender equality in radiation oncology and radiation research—An interdisciplinary prospective survey among the young workforce Open
Purpose There is an urgent need to recruit and retain young professionals in radiation oncology and radiation research as the healthcare system faces major challenges. Our study investigated the experiences and needs of young professionals…
View article: Radiotherapy outcomes and risk factors for young patients with head-and-neck squamous cell carcinomas: a matched-pair analysis
Radiotherapy outcomes and risk factors for young patients with head-and-neck squamous cell carcinomas: a matched-pair analysis Open
Background Head-and-neck squamous cell carcinomas (HNSCC) exhibit significant variations in incidence and outcomes across age groups. There is conflicting data on the oncological outcomes of younger HNSCC patients ≤ 45 years. This study an…
View article: Stereotactic radiotherapy for spinal and non-spinal bone metastases: a patterns-of-care analysis in German-speaking countries as part of a project of the interdisciplinary Radiosurgery and Stereotactic Radiotherapy Working Group of the DEGRO/DGMP
Stereotactic radiotherapy for spinal and non-spinal bone metastases: a patterns-of-care analysis in German-speaking countries as part of a project of the interdisciplinary Radiosurgery and Stereotactic Radiotherapy Working Group of the DEGRO/DGMP Open
Background and purpose Bone metastases constitute a common indication for both conventional radiotherapy (RT) and stereotactic body radiotherapy (SBRT). Although in recent years guidelines have been proposed for SBRT of spinal and non-spin…
View article: Definitive Radiotherapie mit Cetuximab oder Durvalumab bei Patienten mit einem lokoregionär fortgeschrittenen Kopf-Hals-Karzinom und einer Cisplatinkontraindikation (NRG-HN004)
Definitive Radiotherapie mit Cetuximab oder Durvalumab bei Patienten mit einem lokoregionär fortgeschrittenen Kopf-Hals-Karzinom und einer Cisplatinkontraindikation (NRG-HN004) Open
View article: Pulmonary Stereotactic Body Radiation Therapy of Oligometastatic Head-and-Neck Squamous Cell Carcinoma: A Multicenter Retrospective Study
Pulmonary Stereotactic Body Radiation Therapy of Oligometastatic Head-and-Neck Squamous Cell Carcinoma: A Multicenter Retrospective Study Open
SBRT for pulmonary metastases achieves excellent local control with minimal toxicity in patients with oligometastatic HNSCC. Prospective trials are needed to determine the optimal timing for integrating SBRT with systemic treatment.
View article: Short-Course Radiotherapy Versus Long-Course Chemoradiotherapy in Total Neoadjuvant Therapy of Rectal Cancer – a Multicenter Analysis of Early Outcomes and Toxicity
Short-Course Radiotherapy Versus Long-Course Chemoradiotherapy in Total Neoadjuvant Therapy of Rectal Cancer – a Multicenter Analysis of Early Outcomes and Toxicity Open
View article: Impact of Target Volume and Dose Concepts on the Outcomes of Prostate Cancer Patients Treated with Stereotactic Body Radiotherapy for Spinal Metastases - A European Multicenter Cohort Study
Impact of Target Volume and Dose Concepts on the Outcomes of Prostate Cancer Patients Treated with Stereotactic Body Radiotherapy for Spinal Metastases - A European Multicenter Cohort Study Open
View article: Predicting cisplatin tolerability in older adults with head and neck cancer – Insights for improved chemoradiation outcomes
Predicting cisplatin tolerability in older adults with head and neck cancer – Insights for improved chemoradiation outcomes Open
We developed predictive models to support clinicians in identifying older adults with HNSCC capable of tolerating ≥ 200 mg/m2 cumulative cisplatin during chemoradiation. Once validated, these models could improve personalized tr…
View article: German radiation oncology’s next generation: a web-based survey of young biologists, medical physicists, and physicians—from problems to solutions
German radiation oncology’s next generation: a web-based survey of young biologists, medical physicists, and physicians—from problems to solutions Open
View article: Induktionstherapie mit Nivolumab und Chemotherapie bei HPV-positiven Oropharynxkarzinomen
Induktionstherapie mit Nivolumab und Chemotherapie bei HPV-positiven Oropharynxkarzinomen Open
Hintergrund und Ziel der Arbeit Eine generelle Therapie-Deeskalation von mit dem humanen Papillomavirus (HPV) assoziierten Oropharynxkarzinomen ohne Selektion dafür geeigneter Patienten hat in den bisherigen Studien keine Gleichwertigkeit …
View article: Dose prescription for stereotactic body radiotherapy: general and organ-specific consensus statement from the DEGRO/DGMP Working Group Stereotactic Radiotherapy and Radiosurgery
Dose prescription for stereotactic body radiotherapy: general and organ-specific consensus statement from the DEGRO/DGMP Working Group Stereotactic Radiotherapy and Radiosurgery Open
Purpose and objective To develop expert consensus statements on multiparametric dose prescriptions for stereotactic body radiotherapy (SBRT) aligning with ICRU report 91. These statements serve as a foundational step towards harmonizing cu…
View article: Effects of tumor treating fields (TTFields) on human mesenchymal stromal cells
Effects of tumor treating fields (TTFields) on human mesenchymal stromal cells Open
Purpose Mesenchymal stromal cells (MSCs) within the glioblastoma microenvironment have been shown to promote tumor progression. Tumor Treating Fields (TTFields) are alternating electric fields with low intensity and intermediate frequency …
View article: Radiochirurgie beim Nierenzellkarzinom: Daten der multizentrischen prospektiven FASTRACK II-Studie
Radiochirurgie beim Nierenzellkarzinom: Daten der multizentrischen prospektiven FASTRACK II-Studie Open
Hintergrund Die stereotaktische Körperstrahlentherapie (SBRT) wird als eine nicht-invasive Therapieoption zur Behandlung des primären Nierenzellkarzinoms (RCC) bei Patienten, die aus internistischen Gründen für eine Operation nicht geeigne…
View article: Evaluating the impact of a rigid and a deformable registration method of pre-treatment images for hypoxia-based dose painting
Evaluating the impact of a rigid and a deformable registration method of pre-treatment images for hypoxia-based dose painting Open
Although the choice of the CTplan-to-PET registration method pre-treatment impacts the HTV localisation and morphology and the corresponding dose distribution, it negligibly affects the TCP in the proposed dose escalation strate…
View article: Improving prediction models by incorporating external data with weights based on similarity
Improving prediction models by incorporating external data with weights based on similarity Open
In clinical settings, we often face the challenge of building prediction models based on small observational data sets. For example, such a data set might be from a medical center in a multi-center study. Differences between centers might …
View article: The significance of partial volume effect on the estimation of hypoxic tumour volume with [18F]FMISO PET/CT
The significance of partial volume effect on the estimation of hypoxic tumour volume with [18F]FMISO PET/CT Open
Background The purpose of this study was to evaluate how a retrospective correction of the partial volume effect (PVE) in [ 18 F]fluoromisonidazole (FMISO) PET imaging, affects the hypoxia discoverability within a gross tumour volume (GTV)…