Alexander S. Pym
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View article: The role of cytochrome bc1 inhibitors in future tuberculosis treatment regimens
The role of cytochrome bc1 inhibitors in future tuberculosis treatment regimens Open
View article: Targeting de novo purine biosynthesis for tuberculosis treatment
Targeting de novo purine biosynthesis for tuberculosis treatment Open
View article: Corrigendum: Longitudinal mitochondrial bioenergetic signatures of blood monocytes and lymphocytes improve during treatment of drug-susceptible pulmonary tuberculosis patients
Corrigendum: Longitudinal mitochondrial bioenergetic signatures of blood monocytes and lymphocytes improve during treatment of drug-susceptible pulmonary tuberculosis patients Open
[This corrects the article DOI: 10.3389/fimmu.2024.1465448.].
View article: Longitudinal mitochondrial bioenergetic signatures of blood monocytes and lymphocytes improve during treatment of drug-susceptible pulmonary tuberculosis patients
Longitudinal mitochondrial bioenergetic signatures of blood monocytes and lymphocytes improve during treatment of drug-susceptible pulmonary tuberculosis patients Open
The impact of human pulmonary tuberculosis (TB) on the bioenergetic metabolism of circulating immune cells remains elusive, as does the resolution of these effects with TB treatment. In this study, the rates of oxidative phosphorylation (O…
View article: Insights into the use of cytochrome bc1 inhibitors for future therapeutic strategies for tuberculosis
Insights into the use of cytochrome bc1 inhibitors for future therapeutic strategies for tuberculosis Open
Recent efforts to improve tuberculosis (TB) treatment options have focused on developing molecules with novel mechanisms of action and identifying optimal treatment regimens. Inhibition of Mycobacterium tuberculosis cytochrome bc1 oxidase …
View article: Targeting de novo purine biosynthesis for tuberculosis treatment
Targeting de novo purine biosynthesis for tuberculosis treatment Open
Tuberculosis remains the leading cause of death from an infectious disease, responsible for 1.3 million deaths annually. Here, we report the discovery of a first-in-class small molecule inhibitor targeting PurF, the first enzyme in the myc…
View article: Detection of a historic reservoir of bedaquiline/clofazimine resistance-associated variants in Mycobacterium tuberculosis
Detection of a historic reservoir of bedaquiline/clofazimine resistance-associated variants in Mycobacterium tuberculosis Open
View article: Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis
Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis Open
Current methods for tuberculosis treatment monitoring are suboptimal. We evaluated plasma matrix metalloproteinase (MMP) and procollagen III N-terminal propeptide concentrations before and during tuberculosis treatment as biomarkers. Plasm…
View article: Elevated Plasma Matrix Metalloproteinase-8 associates with Sputum Culture Positivity in Pulmonary Tuberculosis
Elevated Plasma Matrix Metalloproteinase-8 associates with Sputum Culture Positivity in Pulmonary Tuberculosis Open
Current methods for tuberculosis (TB) treatment monitoring are suboptimal. We evaluated plasma matrix metalloproteinase (MMP) and procollagen III N-terminal propeptide concentrations before and during TB treatment as biomarkers. Plasma MMP…
View article: The Tuberculosis Drug Accelerator at year 10: what have we learned?
The Tuberculosis Drug Accelerator at year 10: what have we learned? Open
View article: Detection of a historic reservoir of bedaquiline / clofazimine resistance associated variants in<i>Mycobacterium tuberculosis</i>
Detection of a historic reservoir of bedaquiline / clofazimine resistance associated variants in<i>Mycobacterium tuberculosis</i> Open
Drug resistance in tuberculosis (TB) poses a major ongoing challenge to public health. The recent inclusion of bedaquiline into TB drug regimens has improved treatment outcomes, but this advance is threatened by the emergence of strains of…
View article: Increased Neutrophil Count and Decreased Neutrophil CD15 Expression Correlate With TB Disease Severity and Treatment Response Irrespective of HIV Co-infection
Increased Neutrophil Count and Decreased Neutrophil CD15 Expression Correlate With TB Disease Severity and Treatment Response Irrespective of HIV Co-infection Open
Tuberculosis remains a leading cause of death globally despite curative treatment, partly due to the difficulty of identifying patients who will not respond to therapy. Simple host biomarkers that correlate with response to drug treatment …
View article: Population-level emergence of bedaquiline and clofazimine resistance-associated variants among patients with drug-resistant tuberculosis in southern Africa: a phenotypic and phylogenetic analysis
Population-level emergence of bedaquiline and clofazimine resistance-associated variants among patients with drug-resistant tuberculosis in southern Africa: a phenotypic and phylogenetic analysis Open
Wellcome Trust, National Institute of Allergy and Infectious Diseases and National Center for Advancing Translational Sciences of the National Institutes of Health.
View article: Evidence for Expanding the Role of Streptomycin in the Management of Drug-Resistant Mycobacterium tuberculosis
Evidence for Expanding the Role of Streptomycin in the Management of Drug-Resistant Mycobacterium tuberculosis Open
In 2019, the WHO tuberculosis (TB) treatment guidelines were updated to recommend only limited use of streptomycin, in favor of newer agents or amikacin as the preferred aminoglycoside for drug-resistant Mycobacterium tuberculosis . Howeve…
View article: Baseline and Emergent Bedaquiline Resistance Associated with Poor Outcomes in Drug-Resistant Tuberculosis
Baseline and Emergent Bedaquiline Resistance Associated with Poor Outcomes in Drug-Resistant Tuberculosis Open
View article: Dynamics of within-host Mycobacterium tuberculosis diversity and heteroresistance during treatment
Dynamics of within-host Mycobacterium tuberculosis diversity and heteroresistance during treatment Open
View article: Bedaquiline resistance in drug-resistant tuberculosis HIV co-infected patients
Bedaquiline resistance in drug-resistant tuberculosis HIV co-infected patients Open
Genetic mutations linked to bedaquiline resistance were found before starting treatment and acquired during treatment in patients with drug-resistant TB and HIV in KwaZulu-Natal, South Africa. Routine bedaquiline resistance testing needs t…
View article: Dynamics of within-host<i>Mycobacterium tuberculosis</i>diversity and heteroresistance during treatment
Dynamics of within-host<i>Mycobacterium tuberculosis</i>diversity and heteroresistance during treatment Open
Background Studying within-host genetic diversity of Mycobacterium tuberculosis ( Mtb ) in patients during treatment may identify adaptations to antibiotic and immune pressure. Understanding the significance of genetic heteroresistance, an…
View article: <i>N</i> -Acetyltransferase 2 Genotypes among Zulu-Speaking South Africans and Isoniazid and <i>N</i> -Acetyl-Isoniazid Pharmacokinetics during Antituberculosis Treatment
<i>N</i> -Acetyltransferase 2 Genotypes among Zulu-Speaking South Africans and Isoniazid and <i>N</i> -Acetyl-Isoniazid Pharmacokinetics during Antituberculosis Treatment Open
The distribution of N -acetyltransferase 2 gene ( NAT2 ) polymorphisms varies considerably among different ethnic groups. Information on NAT2 single-nucleotide polymorphisms in the South African population is limited. We investigated NAT2 …
View article: N-acetyltransferase 2 genotypes amongst Zulu Speaking South Africans and isoniazid /<i>N</i>-acetyl-isoniazid pharmacokinetics during anti-tuberculosis treatment
N-acetyltransferase 2 genotypes amongst Zulu Speaking South Africans and isoniazid /<i>N</i>-acetyl-isoniazid pharmacokinetics during anti-tuberculosis treatment Open
Background Distribution of N-acetyltransferase2 ( NAT2 ) polymorphisms varies considerably among different ethnic groups. Information on NAT2 single-nucleotide polymorphisms in South African population is limited. We investigated NAT2 poly…
View article: Space-time clustering of recently-diagnosed tuberculosis and impact of ART scale-up: Evidence from an HIV hyper-endemic rural South African population
Space-time clustering of recently-diagnosed tuberculosis and impact of ART scale-up: Evidence from an HIV hyper-endemic rural South African population Open
View article: Publisher Correction: Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis
Publisher Correction: Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis Open
View article: Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis
Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis Open
View article: Correction to: Whole genome sequencing Mycobacterium tuberculosis directly from sputum identifies more genetic diversity than sequencing from culture
Correction to: Whole genome sequencing Mycobacterium tuberculosis directly from sputum identifies more genetic diversity than sequencing from culture Open
He authors reported that one of the authors’ names was typeset incorrectly in the authorship list.
View article: Erratum for O’Donnell et al., “Early Detection of Emergent Extensively Drug-Resistant Tuberculosis by Flow Cytometry-Based Phenotyping and Whole-Genome Sequencing”
Erratum for O’Donnell et al., “Early Detection of Emergent Extensively Drug-Resistant Tuberculosis by Flow Cytometry-Based Phenotyping and Whole-Genome Sequencing” Open
Volume 63, no. 4, e01834-18, 2019, [https://doi.org/10.1128/AAC.01834-18][1]. Figure 3: panel B was missing from the figure. The complete [Fig. 3][2] is shown below.
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[2]: #F1
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View article: Whole genome sequencing Mycobacterium tuberculosis directly from sputum identifies more genetic diversity than sequencing from culture
Whole genome sequencing Mycobacterium tuberculosis directly from sputum identifies more genetic diversity than sequencing from culture Open
He authors reported that one of the authors' names was typeset incorrectly in the authorship list.
View article: Point of care Xpert MTB/RIF versus smear microscopy for tuberculosis diagnosis in southern African primary care clinics: a multicentre economic evaluation
Point of care Xpert MTB/RIF versus smear microscopy for tuberculosis diagnosis in southern African primary care clinics: a multicentre economic evaluation Open
View article: Effect of Xpert MTB/RIF on clinical outcomes in routine care settings: individual patient data meta-analysis
Effect of Xpert MTB/RIF on clinical outcomes in routine care settings: individual patient data meta-analysis Open
View article: Early Detection of Emergent Extensively Drug-Resistant Tuberculosis by Flow Cytometry-Based Phenotyping and Whole-Genome Sequencing
Early Detection of Emergent Extensively Drug-Resistant Tuberculosis by Flow Cytometry-Based Phenotyping and Whole-Genome Sequencing Open
A critical gap in tuberculosis (TB) treatment is detection of emergent drug resistance. We hypothesized that advanced phenotyping with whole-genome sequencing (WGS) will detect low-frequency Mycobacterium tuberculosis drug resistance.
View article: Neutrophil-specific biomarkers as proxy for Mycobacterium tuberculosis (Mtb) burden, lung damage and treatment response kinetics
Neutrophil-specific biomarkers as proxy for Mycobacterium tuberculosis (Mtb) burden, lung damage and treatment response kinetics Open