Christian Schaefer
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View article: Landscape structure, climate variability, and soil quality shape crop biomass patterns in agricultural ecosystems of Bavaria
Landscape structure, climate variability, and soil quality shape crop biomass patterns in agricultural ecosystems of Bavaria Open
Understanding how environmental variability shapes crop biomass is essential for improving yield stability and guiding climate-resilient agriculture. To address this, we compared biomass estimates from a semi-empirical light use efficiency…
View article: (Pre-) atherosclerotic vessel changes in patients with chronic obstructive pulmonary disease and eosinophilia
(Pre-) atherosclerotic vessel changes in patients with chronic obstructive pulmonary disease and eosinophilia Open
Background Chronic obstructive pulmonary disease (COPD) is accompanied by systemic inflammation and an increased risk of cardiovascular diseases, including atherosclerosis and abdominal aortic aneurysms. Eosinophilic inflammation is common…
View article: Blood Eosinophil Count in Asthma Is Associated With Increased Abdominal Aortic Diameter and Increased Vascular Stiffness
Blood Eosinophil Count in Asthma Is Associated With Increased Abdominal Aortic Diameter and Increased Vascular Stiffness Open
In patients with asthma, blood eosinophil count (BEC) is correlated with a wider aortic diameter and heightened vascular stiffness in the abdominal aorta. Hence, they may be at an elevated risk of developing an AAA.
View article: Blood eosinophil count is associated with early atherosclerotic artery changes in asthma
Blood eosinophil count is associated with early atherosclerotic artery changes in asthma Open
Objective Asthma is linked to atherosclerosis, yet the underlying mediators remain elusive. Eosinophils may contribute to both asthmatic and atherosclerotic inflammation. Hence, this study aimed to explore the potential associations of eos…
View article: A RAND/UCLA-Modified VAS Study on Telemedicine, Telehealth, and Virtual Care in Daily Clinical Practice of Vascular Medicine
A RAND/UCLA-Modified VAS Study on Telemedicine, Telehealth, and Virtual Care in Daily Clinical Practice of Vascular Medicine Open
Background: Telemedicine is increasingly used in several fields of healthcare, including vascular medicine. This study aimed to investigate the views of experts and propose clinical practice recommendations on the possible applications of …
View article: Impact of interstitial lung disease on left ventricular myocardial function
Impact of interstitial lung disease on left ventricular myocardial function Open
Background Interstitial lung disease (ILD) comprises a wide variety of pulmonary parenchymal disorders within which progressive fibrosing ILD (PF-ILD) constitutes a phenotypic subset. By use of speckle tracking-based strain analysis we aim…
View article: Pseudoxanthoma elasticum is associated with cardiocirculatory inefficiency
Pseudoxanthoma elasticum is associated with cardiocirculatory inefficiency Open
Pseudoxanthoma elasticum (PXE) is a rare, genetic, metabolic disease characterized by dystrophic calcification of elastic fibres in the skin, retina and vascular wall. Data on cardiac involvement are inconsistent. Hence, we aimed to evalua…
View article: MR Enterography in Crohnʼs Disease: Comparison of Contrast Imaging with Diffusion-weighted Imaging and a special Form of Color Coding
MR Enterography in Crohnʼs Disease: Comparison of Contrast Imaging with Diffusion-weighted Imaging and a special Form of Color Coding Open
We compared contrast-enhanced MR enterography with diffusion-weighted sequences to evaluate the validity of diffusion-weighted sequences for activity assessment in Crohnʼs disease compared to endoscopy. In addition, we investigated a new c…
View article: Skeletal Status in Patients Scheduled for Elective Lumbar Spine Surgery: Comparison of Discectomy, Decompression, Fusion, and Revision
Skeletal Status in Patients Scheduled for Elective Lumbar Spine Surgery: Comparison of Discectomy, Decompression, Fusion, and Revision Open
Study Design Retrospective Cohort Study Objectives To investigate and compare the prevalence of low bone mineral density (BMD) and abnormal laboratory bone metabolism parameters in patients undergoing elective primary discectomy, decompres…
View article: Pulmonary affection of patients with Pseudoxanthoma elasticum: Long-term development and genotype-phenotype-correlation
Pulmonary affection of patients with Pseudoxanthoma elasticum: Long-term development and genotype-phenotype-correlation Open
Pseudoxanthoma elasticum (PXE) is a rare, heritable disease caused by various, mainly recessively transmitted mutations in the ABCC6 gene. Due to calcification of soft connective tissue phenotypic hallmarks are progressive loss of vision, …
View article: Multiple instance learning detects peripheral arterial disease from high-resolution color fundus photography
Multiple instance learning detects peripheral arterial disease from high-resolution color fundus photography Open
Peripheral arterial disease (PAD) is caused by atherosclerosis and is a common disease of the elderly leading to excess morbidity and mortality. Early PAD diagnosis is important, as the only available causal therapy is addressing risk fact…
View article: Therapy of Pseudoxanthoma Elasticum: Current Knowledge and Future Perspectives
Therapy of Pseudoxanthoma Elasticum: Current Knowledge and Future Perspectives Open
Pseudoxanthoma elasticum (PXE) is a rare, genetic, metabolic disease with an estimated prevalence of between 1 per 25,000 and 56,000. Its main hallmarks are characteristic skin lesions, development of choroidal neovascularization, and earl…
View article: Retinal and choriocapillaris perfusion are associated with ankle-brachial-pressure-index and Fontaine stage in peripheral arterial disease
Retinal and choriocapillaris perfusion are associated with ankle-brachial-pressure-index and Fontaine stage in peripheral arterial disease Open
The purpose of this prospective case–control study was to assess whether parameters of retinal and choriocapillaris perfusion are altered in patients with peripheral arterial disease (PAD). Patients with PAD and healthy controls were image…
View article: Long‐term incidence of upper extremity venous obstruction in implantable cardioverter defibrillator patients
Long‐term incidence of upper extremity venous obstruction in implantable cardioverter defibrillator patients Open
Background Very little is known about the long‐term prevalence of severe venous obstruction and occlusion in patients with transvenous implantable cardioverter‐defibrillator leads. The objective of the current investigation was to elucidat…
View article: Long‐term clinical outcome and mortality risks after paclitaxel‐coated balloon angioplasty in patients with peripheral artery disease: An observational clinical study
Long‐term clinical outcome and mortality risks after paclitaxel‐coated balloon angioplasty in patients with peripheral artery disease: An observational clinical study Open
Background and aims Drug‐eluting devices (DEDs) are usually used as a standard therapy for revascularization in femoropopliteal artery disease. Randomized controlled trails have found that DEDs with paclitaxel result in superior patency ra…
View article: Hyaluronic Acid-based Filler Injection: Late-onset Thrombosis of the Frontal Vein
Hyaluronic Acid-based Filler Injection: Late-onset Thrombosis of the Frontal Vein Open
Summary Thrombosis is a serious complication of a hyaluronic acid-based filler injection. Little is known about the late-onset complications of fillers; therefore, an optimal complication management is necessary. In this case report, we de…
View article: Radial artery occlusion after cardiac catheterization and impact of medical treatment
Radial artery occlusion after cardiac catheterization and impact of medical treatment Open
Summary: Background: The transradial artery approach is the preferred access for cardiac catheterization according to current guidelines. However, the most common complication is radial artery occlusion (RAO). Despite the rare indication f…
View article: Endovascular management of femoral access-site and access-related vascular complications following percutaneous coronary interventions (PCI)
Endovascular management of femoral access-site and access-related vascular complications following percutaneous coronary interventions (PCI) Open
For patients who cannot tolerate vascular surgery due to advanced cardiovascular disease or are in a bailout situation, endovascular management of VCs following PCIs seems to be a feasible and safe treatment option, and represents an alter…
View article: Three-dimensional bioprinting using a coaxial needle with viscous inks in bone tissue engineering - An In vitro study
Three-dimensional bioprinting using a coaxial needle with viscous inks in bone tissue engineering - An In vitro study Open
Using a coaxial needle enables printing of a stable scaffold with viable stem cells. Furthermore, cell viability is maintained after the bioprinting process.
View article: A Novel Gene Signature-Based Model Predicts Biochemical Recurrence-Free Survival in Prostate Cancer Patients after Radical Prostatectomy
A Novel Gene Signature-Based Model Predicts Biochemical Recurrence-Free Survival in Prostate Cancer Patients after Radical Prostatectomy Open
Currently, decision-making regarding biochemical recurrence (BCR) following prostatectomy relies solely on clinical parameters. We therefore attempted to develop an integrated prediction model based on a molecular signature and clinicopath…
View article: Comparative study of pressure (ankle-brachial pressure index) and flow (strain gauge plethysmography and reactive hyperaemia) measurements in diagnosis of peripheral arterial disease in patients with severe aortic stenosis
Comparative study of pressure (ankle-brachial pressure index) and flow (strain gauge plethysmography and reactive hyperaemia) measurements in diagnosis of peripheral arterial disease in patients with severe aortic stenosis Open
Peak flow at 5 seconds is one of flow value that correlated well with ankle-brachial pressure index in detecting peripheral arterial disease in patients with and without aortic stenosis. Detection of peripheral arterial disease in patients…
View article: Brief report – Telomere length is a poor biomarker to predict 1-year mortality or cardiovascular comorbidity in patients with transcatheter aortic valve replacement
Brief report – Telomere length is a poor biomarker to predict 1-year mortality or cardiovascular comorbidity in patients with transcatheter aortic valve replacement Open
In elderly patients with severe aortic valve stenosis, leucocyte telomere length did not predict post-procedural survival. The correlation between long telomere length and reduced LVEF in these patients deserves further attention.
View article: Impact of <sup>68</sup>Ga-PSMA PET/CT on the Radiotherapeutic Approach to Prostate Cancer in Comparison to CT: A Retrospective Analysis
Impact of <sup>68</sup>Ga-PSMA PET/CT on the Radiotherapeutic Approach to Prostate Cancer in Comparison to CT: A Retrospective Analysis Open
68Ga-prostate-specific membrane antigen PET/CT (68Ga-PSMA PET/CT) offers unprecedented accuracy for staging of primary, persistent, or recurrent prostate cancer. Thus, we hypothesized that 68Ga-PSMA PET/CT before radiotherapy significantly…
View article: Impairment of vascular strain in patients with obstructive sleep apnea
Impairment of vascular strain in patients with obstructive sleep apnea Open
BackgroundObstructive sleep apnea (OSA) is an independent risk factor for the development of cardiovascular diseases. Aim of this present study was to evaluate and extend recent research on the influence of obstructive sleep apnea on vascu…