Alexander Shaffer
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View article: P-2158. A Single Center's Utilization of Cell Free Microbial DNA Testing
P-2158. A Single Center's Utilization of Cell Free Microbial DNA Testing Open
Background Metagenomic next generation sequencing techniques, either through targeted (tMGS) or shotgun sequencing (sMGS), have been shown to improve the odds of identifying a causative pathogen in a variety of disease states compared to c…
View article: Metformin Attenuates Inflammatory Responses and Enhances Antibody Production in an Acute Pneumonia Model of Streptococcus pneumoniae
Metformin Attenuates Inflammatory Responses and Enhances Antibody Production in an Acute Pneumonia Model of Streptococcus pneumoniae Open
Metformin may potentially reverse various age-related conditions; however, it is unclear whether metformin can also mitigate or delay the deterioration of immunological resilience that occurs in the context of infections that are commonly …
View article: OCTREOTIDE FOR CONTROL OF PAIN IN HYPERTROPHIC PULMONARY OSTEOARTHROPATHY
OCTREOTIDE FOR CONTROL OF PAIN IN HYPERTROPHIC PULMONARY OSTEOARTHROPATHY Open
View article: 2019 ATS/IDSA CRITERIA TO IDENTIFY P. AERUGINOSA AND MRSA PROMOTE OVERUTILIZATION OF MRSA THERAPY IN NON-SEVERE CAP
2019 ATS/IDSA CRITERIA TO IDENTIFY P. AERUGINOSA AND MRSA PROMOTE OVERUTILIZATION OF MRSA THERAPY IN NON-SEVERE CAP Open
View article: MULTI-DRUG RESISTANT PATHOGEN SCORES PROMOTE THE OVERUSE OF ANTI-PSEUDOMONAS ANTIBIOTICS
MULTI-DRUG RESISTANT PATHOGEN SCORES PROMOTE THE OVERUSE OF ANTI-PSEUDOMONAS ANTIBIOTICS Open
View article: Transcriptional Profiling of Synovial Macrophages Using Minimally Invasive Ultrasound‐Guided Synovial Biopsies in Rheumatoid Arthritis
Transcriptional Profiling of Synovial Macrophages Using Minimally Invasive Ultrasound‐Guided Synovial Biopsies in Rheumatoid Arthritis Open
Objective Currently, there are no reliable biomarkers for predicting therapeutic response in patients with rheumatoid arthritis ( RA ). The synovium may unlock critical information for determining efficacy, since a reduction in the numbers…
View article: TGF-β–induced intracellular PAI-1 is responsible for retaining hematopoietic stem cells in the niche
TGF-β–induced intracellular PAI-1 is responsible for retaining hematopoietic stem cells in the niche Open
Key Points TGF-β–induced intracellular PAI-1 regulates the balance of HSPCs localization between BM and periphery. Intracellular PAI-1 inhibits Furin-dependent maturation of MT1-MMP in HSPCs, resulting in the suppression of HSPC motility.
View article: Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span
Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span Open
Little is known about the relative importance of monocyte and tissue-resident macrophages in the development of lung fibrosis. We show that specific genetic deletion of monocyte-derived alveolar macrophages after their recruitment to the l…
View article: ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model
ApoE deficiency exacerbates the development and sustainment of a semi-chronic K/BxN serum transfer-induced arthritis model Open