Alexander T. Sack
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View article: Cardiac, respiratory, and gastric rhythms independently modulate motor corticospinal excitability in humans
Cardiac, respiratory, and gastric rhythms independently modulate motor corticospinal excitability in humans Open
Interoception refers to the brain’s sensing of internal body state and encompasses various bodily systems, notably the cardiac, respiratory, and gastric rhythms. Beyond their roles in physiological regulation and emotional states, each of …
View article: EEG-Based Prediction of rTMS Treatment Response in Depression: Nonlinear Features and Machine Learning with Minimal Electrode
EEG-Based Prediction of rTMS Treatment Response in Depression: Nonlinear Features and Machine Learning with Minimal Electrode Open
Background Repetitive transcranial magnetic stimulation (rTMS) is an established intervention for treatment-resistant depression, but response rates remain highly variable and reliable predictors of outcome are lacking. Resting-state elect…
View article: Rethinking Migraine Prevention: A Systematic Review Comparing Noninvasive Brain Stimulation and Pharmacological Treatments
Rethinking Migraine Prevention: A Systematic Review Comparing Noninvasive Brain Stimulation and Pharmacological Treatments Open
View article: TMS-induced heart-brain coupling associated with early clinical response in depression
TMS-induced heart-brain coupling associated with early clinical response in depression Open
View article: Defining individualized theta frequency for memory modulation: A machine learning approach across brain states and regions
Defining individualized theta frequency for memory modulation: A machine learning approach across brain states and regions Open
Recent transcranial alternating current stimulation (tACS) studies suggest that theta-frequency stimulation can modulate memory performance, with evidence highlighting individual variability in optimal stimulation frequency. However, it re…
View article: Clinical effectiveness of switching to right lateral orbitofrontal cortex-TMS after failure of sequential bilateral dorsolateral prefrontal-TMS in major depression
Clinical effectiveness of switching to right lateral orbitofrontal cortex-TMS after failure of sequential bilateral dorsolateral prefrontal-TMS in major depression Open
View article: From Rhythm to Relief: Heart Rate Variability as a Window into Anhedonia Response During Agomelatine Treatment in Major Depressive Disorder
From Rhythm to Relief: Heart Rate Variability as a Window into Anhedonia Response During Agomelatine Treatment in Major Depressive Disorder Open
Background and Objectives: Anhedonia, a core symptom of major depressive disorder (MDD), is a known predictor of treatment response. It has been linked to heart rate variability (HRV), a physiological marker implicated in both MDD and card…
View article: Enhancing cognitive performance with fronto-parietal transcranial alternating current stimulation
Enhancing cognitive performance with fronto-parietal transcranial alternating current stimulation Open
Executive cognitive functions are essential for human life, and their age- or disease-related decline significantly impacts quality of life. Non-invasive brain stimulation (NIBS) targeting the multiple-demand or fronto-parietal network (FP…
View article: Heart Rate Variability as an Early Biomarker of Anhedonia Improvement During Agomelatine Treatment in Depression
Heart Rate Variability as an Early Biomarker of Anhedonia Improvement During Agomelatine Treatment in Depression Open
Background and Objectives: Anhedonia, a core symptom of major depressive disorder (MDD), is a known predictor of treatment response. It has been linked to heart rate variability (HRV), a physiological marker implicated in both MDD and card…
View article: Transcranial magnetic stimulation to treat 101 patients with depression and comorbid personality disorders in a real-world naturalistic clinical setting: feasibility, tolerability and effectiveness
Transcranial magnetic stimulation to treat 101 patients with depression and comorbid personality disorders in a real-world naturalistic clinical setting: feasibility, tolerability and effectiveness Open
View article: Optimizing rTMS Localization for Hippocampal Modulation: Individualized Connectivity-Based Targeting versus Scalp-Based Heuristics
Optimizing rTMS Localization for Hippocampal Modulation: Individualized Connectivity-Based Targeting versus Scalp-Based Heuristics Open
View article: Motor Imagery-Based Individualized Alpha Transcranial Alternating Current Stimulation: Effects on Brain Oscillations and Motor Function
Motor Imagery-Based Individualized Alpha Transcranial Alternating Current Stimulation: Effects on Brain Oscillations and Motor Function Open
View article: Top-down attentional control resilience reveals time-sensitive transcranial magnetic stimulation effects
Top-down attentional control resilience reveals time-sensitive transcranial magnetic stimulation effects Open
The frontal eye fields (FEFs) are critically involved in voluntary shifts of attention by sending top-down signals to posterior cortices to modulate local alpha-band activity. However, the exact temporo-spatial dynamics of this process are…
View article: Consensus guidelines for the use of concurrent TMS-fMRI in cognitive and clinical neuroscience
Consensus guidelines for the use of concurrent TMS-fMRI in cognitive and clinical neuroscience Open
Concurrent transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (TMS-fMRI) provides a step-change in the toolkit of neuroscience research. TMS enables the noninvasive perturbation of ongoing human brain activit…
View article: Comparison of 5-Day Multidaily Neuronavigated Theta-Burst Sessions With 6-Week Standard Repetitive Transcranial Magnetic Stimulation (the Dutch Depression Outcome Trial): Protocol for a Randomized Controlled Trial
Comparison of 5-Day Multidaily Neuronavigated Theta-Burst Sessions With 6-Week Standard Repetitive Transcranial Magnetic Stimulation (the Dutch Depression Outcome Trial): Protocol for a Randomized Controlled Trial Open
Background Novel therapies are crucial for patients with major depressive disorder, as more than 33% of patients do not respond to first-line treatments. A promising novel treatment strategy is an intensive 5-day course of personalized, fu…
View article: Generalizing animal movement predictions across landscapes: a scalable framework grounded in empirical telemetry data
Generalizing animal movement predictions across landscapes: a scalable framework grounded in empirical telemetry data Open
Background Accurately predicting animal movement across broad ecological contexts is vital for effective wildlife management, yet most models are developed for specific locations and fail to generalize across diverse landscapes. New approa…
View article: Cognitive and Psychological Symptoms in Post-COVID-19 Condition: A Systematic Review of Structural and Functional Neuroimaging, Neurophysiology, and Intervention Studies
Cognitive and Psychological Symptoms in Post-COVID-19 Condition: A Systematic Review of Structural and Functional Neuroimaging, Neurophysiology, and Intervention Studies Open
This review highlights the complex neurologic underpinnings of PCC and the potential of NIBS and cognitive rehabilitation as interventions. Further research is essential to refine these interventions and establish evidence-based strategies…
View article: Comparison of effectiveness of common targeting heuristics in repetitive transcranial magnetic stimulation treatment of depression
Comparison of effectiveness of common targeting heuristics in repetitive transcranial magnetic stimulation treatment of depression Open
Background Repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) is an effective non-pharmacological, non-invasive intervention for depression. However, the optimal strategy for localising t…
View article: In-phase and anti-phase dual-site beta tACS differentially influence functional connectivity and motor inhibition
In-phase and anti-phase dual-site beta tACS differentially influence functional connectivity and motor inhibition Open
Inhibitory control relies on coordinated beta-band activity within a fronto-basal ganglia network, which implements inhibition via downstream effects on (pre)motor areas. In this study, we employed dual-site transcranial alternating curren…
View article: Affective state-dependent effects of prefrontal rTMS on the cognitive control of negative stimuli in healthy and depressed individuals
Affective state-dependent effects of prefrontal rTMS on the cognitive control of negative stimuli in healthy and depressed individuals Open
View article: 153. Treatment Selection for Antidepressants or rTMS Using Raw EEG and CNN Transfer Learning
153. Treatment Selection for Antidepressants or rTMS Using Raw EEG and CNN Transfer Learning Open
View article: Evaluating Right Lateral Orbitofrontal Cortex (R-LOFC) TMS: A Rescue Option for DLPFC-TMS Non-Responders and Insights Into its Role in Initial Combination Protocols
Evaluating Right Lateral Orbitofrontal Cortex (R-LOFC) TMS: A Rescue Option for DLPFC-TMS Non-Responders and Insights Into its Role in Initial Combination Protocols Open
View article: Sequential bilateral dorsolateral prefrontal versus right lateral orbitofrontal/left dorsolateral prefrontal TMS for major depression: A large naturalistic case series
Sequential bilateral dorsolateral prefrontal versus right lateral orbitofrontal/left dorsolateral prefrontal TMS for major depression: A large naturalistic case series Open
View article: Simultaneous tACS-fMRI reveals state- and frequency-specific modulation of hippocampal-cortical functional connectivity
Simultaneous tACS-fMRI reveals state- and frequency-specific modulation of hippocampal-cortical functional connectivity Open
Non-invasive indirect hippocampal-targeted stimulation is of broad scientific and clinical interest. Transcranial alternating current stimulation (tACS) is appealing because it allows oscillatory stimulation to study hippocampal theta (3-8…
View article: Note of concern regarding the sources of scientific evidence used to justify the Reclassification of Non-Invasive Brain Stimulation (NIBS) Devices without an intended medical purpose into Class III
Note of concern regarding the sources of scientific evidence used to justify the Reclassification of Non-Invasive Brain Stimulation (NIBS) Devices without an intended medical purpose into Class III Open
View article: A comparison of clinical outcomes using sequential right lateral orbitofrontal cortex/left DLPFC-TMS, versus conventional sequential bilateral DLPFC-TMS for major depressive disorder, in a large naturalistic patient sample
A comparison of clinical outcomes using sequential right lateral orbitofrontal cortex/left DLPFC-TMS, versus conventional sequential bilateral DLPFC-TMS for major depressive disorder, in a large naturalistic patient sample Open
View article: Affective State-Dependent Effects of Prefrontal Rtms on the Cognitive Control of Negative Stimuli in Healthy and Depressed Individuals
Affective State-Dependent Effects of Prefrontal Rtms on the Cognitive Control of Negative Stimuli in Healthy and Depressed Individuals Open
View article: Clinical outcomes for right orbitofrontal 1 Hz TMS in nonresponders to conventional high-frequency left dorsolateral prefrontal TMS among patients with major depression
Clinical outcomes for right orbitofrontal 1 Hz TMS in nonresponders to conventional high-frequency left dorsolateral prefrontal TMS among patients with major depression Open
View article: The effect of in- and anti-phase beta tACS on motor inhibition: a concurrent dual-site tACS-EEG and tACS-fMRI study
The effect of in- and anti-phase beta tACS on motor inhibition: a concurrent dual-site tACS-EEG and tACS-fMRI study Open
View article: Optimizing rTMS Localization for Hippocampal Modulation: Individualized Connectivity-Based Targeting versus Scalp-Based Heuristics
Optimizing rTMS Localization for Hippocampal Modulation: Individualized Connectivity-Based Targeting versus Scalp-Based Heuristics Open