Alexander Teumer
YOU?
Author Swipe
View article: DNA methylation of genes involved in lipid metabolism drives adiponectin levels and metabolic disease
DNA methylation of genes involved in lipid metabolism drives adiponectin levels and metabolic disease Open
Aims/hypothesis Despite playing critical roles in the pathophysiology of type 2 diabetes and other metabolic disorders, the molecular mechanisms underlying circulating adipokine levels remain poorly understood. By identifying genomic regio…
View article: A methylome-wide association study of major depression with out-of-sample case–control classification and trans-ancestry comparison
A methylome-wide association study of major depression with out-of-sample case–control classification and trans-ancestry comparison Open
Major depression (MD) is a leading cause of global disease burden, and both experimental and population-based studies suggest that differences in DNA methylation may be associated with the condition. However, previous DNA methylation studi…
View article: Using Two-Sample Mendelian Randomization to Identify Potential Drug Targets: The Case of Desmoplakin
Using Two-Sample Mendelian Randomization to Identify Potential Drug Targets: The Case of Desmoplakin Open
BACKGROUND Two-sample Mendelian randomization (2SMR) is a powerful tool for causal hypothesis testing. However, the simplicity of the statistical techniques combined with lack of causal inference reasoning has prompted an explosion of 2SMR…
View article: Novel and Known Genetic Players in Hypertension: From Gene Expression to Striking Insights
Novel and Known Genetic Players in Hypertension: From Gene Expression to Striking Insights Open
Cardiovascular diseases (CVDs) are the most common non-communicable diseases, responsible for 17.9 million deaths each year. Hypertension is a major risk factor for CVDs. Gene expression data obtained from RNA sequencing can help identify …
View article: Time to change the electrocardiography (ECG) indices of left ventricular hypertrophy: the Bialystok PLUS and SHIP-TREND population-based studies
Time to change the electrocardiography (ECG) indices of left ventricular hypertrophy: the Bialystok PLUS and SHIP-TREND population-based studies Open
Background Left ventricular hypertrophy (LVH) represents a significant risk factor for cardiovascular disease (CVD). Electrocardiography (ECG) is a commonly used diagnostic tool for LVH, however, its accuracy and sensitivity are limited. P…
View article: Cross-sectional and longitudinal association of seven DNAm-based predictors with metabolic syndrome and type 2 diabetes
Cross-sectional and longitudinal association of seven DNAm-based predictors with metabolic syndrome and type 2 diabetes Open
Background To date, various epigenetic clocks have been constructed to estimate biological age, most commonly using DNA methylation (DNAm). These include “first-generation” clocks such as DNAmAgeHorvath and “second-generation” clocks such …
View article: Genomic and molecular evidence that the lncRNA<i>DSP-AS1</i>modulates Desmoplakin expression
Genomic and molecular evidence that the lncRNA<i>DSP-AS1</i>modulates Desmoplakin expression Open
Cardiac desmosomes are specialized cell junctions responsible for cardiomyocytes mechanical coupling. Mutation in desmosomal genes cause autosomal dominant and recessive familial arrhythmogenic cardiomyopathy. Motivated by evidence that Me…
View article: Insights from a methylome-wide association study of antidepressant exposure
Insights from a methylome-wide association study of antidepressant exposure Open
This study tests the association of whole-blood DNA methylation and antidepressant exposure in 16,531 individuals from Generation Scotland (GS), using self-report and prescription-derived measures. We identify 8 associations and a high con…
View article: Genomics of diffusion-imaging integrating GWAS, exome data and single-cell sequencing unravels lifespan determinants of cerebral small vessel disease
Genomics of diffusion-imaging integrating GWAS, exome data and single-cell sequencing unravels lifespan determinants of cerebral small vessel disease Open
Peak width of skeletonized mean diffusivity (PSMD) is an emerging automated diffusion imaging marker showing clinically relevant changes in cerebral small vessel disease (cSVD), a leading cause of stroke and dementia with no mechanism-base…
View article: Associations between common genetic variants and income provide insights about the socio-economic health gradient
Associations between common genetic variants and income provide insights about the socio-economic health gradient Open
We conducted a genome-wide association study on income among individuals of European descent ( N = 668,288) to investigate the relationship between socio-economic status and health disparities. We identified 162 genomic loci associated wit…
View article: DNA Methylation Signatures of Cardiovascular Health Provide Insights into Diseases
DNA Methylation Signatures of Cardiovascular Health Provide Insights into Diseases Open
Background The association of overall cardiovascular health (CVH) with changes in DNA methylation (DNAm) has not been well characterized. Methods We calculated the American Heart Association’s Life’s Essential 8 (LE8) score to reflect CVH …
View article: Cardiovascular risk and preclinical atherosclerosis are associated with white matter hyperintensities in apparently healthy adults: the population-based cross-sectional study BIALYSTOK PLUS
Cardiovascular risk and preclinical atherosclerosis are associated with white matter hyperintensities in apparently healthy adults: the population-based cross-sectional study BIALYSTOK PLUS Open
The cardiovascular risk class, presence of carotid plaques, increased intima‑media complex thickness, and diabetes are the main risk factors for white matter hyperintensities in apparently healthy adults. People without hypertension or dia…
View article: A meta-analysis of genome-wide studies of resilience in the German population
A meta-analysis of genome-wide studies of resilience in the German population Open
View article: Integrating multiple kidney function markers to predict all-cause and cardiovascular disease mortality: prospective analysis of 366 758 UK Biobank participants
Integrating multiple kidney function markers to predict all-cause and cardiovascular disease mortality: prospective analysis of 366 758 UK Biobank participants Open
Background Reduced kidney function is a risk factor of cardiovascular and all-cause mortality. This association was demonstrated for several kidney function markers, but it is unclear whether integrating multiple measured markers may impro…
View article: Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling
Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling Open
The major anxiety disorders (ANX; including generalized anxiety disorder, panic disorder, and phobias ) are highly prevalent, often onset early, persist throughout life, and cause substantial global disability. Although distinct in their c…
View article: New insights into the hypothalamic–pituitary–thyroid axis: a transcriptome- and proteome-wide association study
New insights into the hypothalamic–pituitary–thyroid axis: a transcriptome- and proteome-wide association study Open
Introduction Thyroid hormones have systemic effects on the human body and play a key role in the development and function of virtually all tissues. They are regulated via the hypothalamic–pituitary–thyroid (HPT) axis and have a heritable c…
View article: Genetic variants for head size share genes and pathways with cancer
Genetic variants for head size share genes and pathways with cancer Open
The size of the human head is highly heritable, but genetic drivers of its variation within the general population remain unmapped. We perform a genome-wide association study on head size (N = 80,890) and identify 67 genetic loci, of which…
View article: Antidepressant Exposure and DNA Methylation: Insights from a Methylome-Wide Association Study
Antidepressant Exposure and DNA Methylation: Insights from a Methylome-Wide Association Study Open
Importance Understanding antidepressant mechanisms could help design more effective and tolerated treatments. Objective Identify DNA methylation (DNAm) changes associated with antidepressant exposure. Design Case-control methylome-wide ass…
View article: Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits Open
View article: Association analysis between an epigenetic alcohol risk score and blood pressure
Association analysis between an epigenetic alcohol risk score and blood pressure Open
Background Epigenome-wide association studies have revealed multiple DNA methylation sites (CpGs) associated with alcohol consumption, an important lifestyle risk factor for cardiovascular diseases. Results We generated an alcohol consumpt…
View article: Association analysis between an epigenetic alcohol risk score and blood pressure
Association analysis between an epigenetic alcohol risk score and blood pressure Open
Background Epigenome-wide association studies have revealed multiple DNA methylation sites (CpGs) associated with alcohol consumption, an important lifestyle risk factor for cardiovascular diseases. Results We generated an alcohol consumpt…
View article: The role of thyroid function in borderline personality disorder and schizophrenia: a Mendelian Randomisation study
The role of thyroid function in borderline personality disorder and schizophrenia: a Mendelian Randomisation study Open
Background Genome-wide association studies have reported a genetic overlap between borderline personality disorder (BPD) and schizophrenia (SCZ). Epidemiologically, the direction and causality of the association between thyroid function an…
View article: Methylation Patterns of the FKBP5 Gene in Association with Childhood Maltreatment and Depressive Disorders
Methylation Patterns of the FKBP5 Gene in Association with Childhood Maltreatment and Depressive Disorders Open
Childhood maltreatment is an important risk factor for adult depression and has been associated with changes in the hypothalamic pituitary adrenal (HPA) axis, including cortisol secretion and methylation of the FKBP5 gene. Furthermore, ass…
View article: Associations between common genetic variants and income provide insights about the socioeconomic health gradient
Associations between common genetic variants and income provide insights about the socioeconomic health gradient Open
We conducted a genome-wide association study (GWAS) on income among individuals of European descent and leveraged the results to investigate the socio-economic health gradient (N=668,288). We found 162 genomic loci associated with a common…
View article: Associations between common genetic variants and income provide insights about the socioeconomic health gradient
Associations between common genetic variants and income provide insights about the socioeconomic health gradient Open
We conducted a genome-wide association study (GWAS) on income among individuals of European descent and leveraged the results to investigate the socio-economic health gradient ( N =668,288). We found 162 genomic loci associated with a comm…
View article: Mendelian randomization indicates causal effects of estradiol levels on kidney function in males
Mendelian randomization indicates causal effects of estradiol levels on kidney function in males Open
Context Chronic kidney disease (CKD) is a public health burden worldwide. Epidemiological studies observed an association between sex hormones, including estradiol, and kidney function. Objective We conducted a Mendelian randomization (MR)…
View article: Correction: Analysis of epidemiological association patterns of serum thyrotropin by combining random forests and Bayesian networks
Correction: Analysis of epidemiological association patterns of serum thyrotropin by combining random forests and Bayesian networks Open
[This corrects the article DOI: 10.1371/journal.pone.0271610.].
View article: A methylome-wide association study of major depression with out-of-sample case-control classification and trans-ancestry comparison
A methylome-wide association study of major depression with out-of-sample case-control classification and trans-ancestry comparison Open
Major Depression (MD) is a leading cause of global disease burden, and both experimental and population-based studies suggest that differences in DNA methylation (DNAm) may be associated with the condition. However, previous DNAm studies h…
View article: Height, Autoimmune Thyroid Disease, and Thyroid Cancer: A Mendelian Randomization Study
Height, Autoimmune Thyroid Disease, and Thyroid Cancer: A Mendelian Randomization Study Open
Background: Increased height has been associated with increased risk of hypothyroidism or thyroid cancer in epidemiological studies. However, the potential causal association between height and hypothyroidism or thyroid cancer has not been…
View article: Alpha-1 Antitrypsin Augmentation and the Liver Phenotype of Adults With Alpha-1 Antitrypsin Deficiency (Genotype Pi∗ZZ)
Alpha-1 Antitrypsin Augmentation and the Liver Phenotype of Adults With Alpha-1 Antitrypsin Deficiency (Genotype Pi∗ZZ) Open