Alexander V. Priezzhev
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View article: Hybrid decorrelation optical coherence tomography for quantification of wide-dynamic-range blood perfusion
Hybrid decorrelation optical coherence tomography for quantification of wide-dynamic-range blood perfusion Open
Accurate quantification of blood perfusion is critical for understanding vascular pathophysiology. Although optical coherence tomography (OCT) can offer an insight into the blood perfusion by measuring three-dimensional blood flow velocity…
View article: Optical measurements of microrheological parameters of blood and analysis of their relationship with its viscosity in cardiovascular diseases
Optical measurements of microrheological parameters of blood and analysis of their relationship with its viscosity in cardiovascular diseases Open
Background and Objectives: Blood plays a key role in supplying oxygen to the body tissues and transporting various substances throughout the body. Thus, the parameters characterizing blood flow reflect the quality of blood functionality. C…
View article: Laser Aggregometry Assessment of Blood Microrheology in a Slit Fluidic Channel Covered With Endothelial Cells
Laser Aggregometry Assessment of Blood Microrheology in a Slit Fluidic Channel Covered With Endothelial Cells Open
The blood rheology in vitro in glass or plastic microfluidic chips is different from that in vivo in blood vessels with similar geometry. Absence of vascular endothelium is suggested to cause these discrepancies. This work aims to perform …
View article: Interrelation of Blood Microrheological Parameters Measured by Optical Methods and Whole Blood Viscosity in Patients Suffering from Blood Disorders: a Pilot Study
Interrelation of Blood Microrheological Parameters Measured by Optical Methods and Whole Blood Viscosity in Patients Suffering from Blood Disorders: a Pilot Study Open
The perfusion of tissues and blood flux strongly depend on several interdependent parameters, such as viscosity of blood, red blood cell aggregation and red blood cell deformation. In case of many blood disorders these parameters are alter…
View article: RBC aggregation, deformation and adhesion to endothelium: Role of nitric oxide derived from L-Arginine and sodium nitroprusside
RBC aggregation, deformation and adhesion to endothelium: Role of nitric oxide derived from L-Arginine and sodium nitroprusside Open
Red blood cells (RBCs) are the most abundant human blood cells. RBC aggregation and deformation strongly determine blood viscosity which impacts hemorheology and microcirculation. In turn, RBC properties depend on different endogenous and …
View article: Effect of sodium nitroprusside on the microrheological properties of red blood cells in different media
Effect of sodium nitroprusside on the microrheological properties of red blood cells in different media Open
Red blood cell (RBC) aggregation as well as their deformation significantly affects blood microrheology. These processes depend on various factors, one of which is concentration of the nitric oxide, one of the main signaling molecule in th…
View article: Correlation between the Capillary Blood Flow Characteristics and Endothelium Function in Healthy Volunteers and Patients Suffering from Coronary Heart Disease and Atrial Fibrillation: A Pilot Study
Correlation between the Capillary Blood Flow Characteristics and Endothelium Function in Healthy Volunteers and Patients Suffering from Coronary Heart Disease and Atrial Fibrillation: A Pilot Study Open
Coronary heart disease (CHD) and atrial fibrillation (AF) pose significant health risks and require accurate diagnostic tools to assess the severity and progression of the diseases. Traditional diagnostic methods have limitations in provid…
View article: Problems of Red Blood Cell Aggregation and Deformation Assessed by Laser Tweezers, Diffuse Light Scattering and Laser Diffractometry
Problems of Red Blood Cell Aggregation and Deformation Assessed by Laser Tweezers, Diffuse Light Scattering and Laser Diffractometry Open
This study aims to highlight the problems with implementing optical techniques (laser tweezers, diffuse light scattering and laser diffractometry) in clinical hemorheological practice. We provide the feasibility of these techniques to asse…
View article: A review of career devoted to Biophotonics – In memoriam to Ekaterina Borisova (1978–2021)
A review of career devoted to Biophotonics – In memoriam to Ekaterina Borisova (1978–2021) Open
started in 2004, when significant efforts were spent to find suitable method for automated classification of skin diseases using spectra and extracting some etalon distributions.The first result was presented at IX national conference of "…
View article: Raman Spectroscopic Study of TiO2 Nanoparticles’ Effects on the Hemoglobin State in Individual Red Blood Cells
Raman Spectroscopic Study of TiO2 Nanoparticles’ Effects on the Hemoglobin State in Individual Red Blood Cells Open
Titanium dioxide (TiO2) is considered to be a nontoxic material and is widely used in a number of everyday products, such as sunscreen. TiO2 nanoparticles (NP) are also considered as prospective agents for photodynamic therapy and drug del…
View article: Use of biomedical photonics for in vivo and in vitro assessment of haemostasis and microcirculation in patients on antithrombotic therapy
Use of biomedical photonics for in vivo and in vitro assessment of haemostasis and microcirculation in patients on antithrombotic therapy Open
Background Antithrombotic therapy in patients with cardiovascular disease requires rapid translation of laboratory assessment of haemorrheological parameters in clinical cardiology practice. Both antiplatelet and anticoagulant agents, espe…
View article: Forces of RBC interaction with single endothelial cells in stationary conditions: Measurements with laser tweezers
Forces of RBC interaction with single endothelial cells in stationary conditions: Measurements with laser tweezers Open
Red blood cells (RBCs) are able to interact and communicate with endothelial cells (ECs). Under some pathological or even normal conditions, the adhesion of RBCs to the endothelium can be observed. Presently, the mechanisms and many aspect…
View article: Assessment of the forces of pair interaction of erythrocytes during their aggregation by the optical tweezers in Type 1 and Type 2 diabetes mellitus
Assessment of the forces of pair interaction of erythrocytes during their aggregation by the optical tweezers in Type 1 and Type 2 diabetes mellitus Open
Objective . Measurement and comparison of the aggregation and disaggregation forces of individual erythrocytes during the formation or breakdown of a paired aggregate in vitro in the blood of patients with type 1 diabetes mellitus (T1DM) a…
View article: Relationship between capillary blood flow parameters measured in vivo and microrheologic parameters of blood measured in vitro in arterial hypertension and coronary heart disease
Relationship between capillary blood flow parameters measured in vivo and microrheologic parameters of blood measured in vitro in arterial hypertension and coronary heart disease Open
Introduction . Blood microcirculation and its microrheologic properties are impaired in cardiovascular diseases. Microrheologic properties are characterized by the red blood cells (RBC) ability to aggregate and disaggregate. Therefore, the…
View article: Multimodal Diagnostics of Microrheologic Alterations in Blood of Coronary Heart Disease and Diabetic Patients
Multimodal Diagnostics of Microrheologic Alterations in Blood of Coronary Heart Disease and Diabetic Patients Open
Coronary heart disease (CHD) has serious implications for human health and needs to be diagnosed as early as possible. In this article in vivo and in vitro optical methods are used to study blood properties related to the aggregation of re…
View article: Pericapillary Edema Assessment by Means of the Nailfold Capillaroscopy and Laser Scanning Microscopy
Pericapillary Edema Assessment by Means of the Nailfold Capillaroscopy and Laser Scanning Microscopy Open
Edema, i.e., fluid accumulation in the interstitial space, accompanies numerous pathological states of the human organism, including heart failure (HF), inflammatory response, and lymphedema. Nevertheless, techniques for quantitative asses…
View article: Effect of Red Blood Cell Aging In Vivo on Their Aggregation Properties In Vitro: Measurements with Laser Tweezers
Effect of Red Blood Cell Aging In Vivo on Their Aggregation Properties In Vitro: Measurements with Laser Tweezers Open
Red blood cell (RBC) aggregation highly influences hemorheology and blood microcirculation in the human body. The aggregation properties of RBCs can vary due to numerous factors, including RBC age. The aim of this work was to estimate in v…
View article: Assessment of Fibrinogen Macromolecules Interaction with Red Blood Cells Membrane by Means of Laser Aggregometry, Flow Cytometry, and Optical Tweezers Combined with Microfluidics
Assessment of Fibrinogen Macromolecules Interaction with Red Blood Cells Membrane by Means of Laser Aggregometry, Flow Cytometry, and Optical Tweezers Combined with Microfluidics Open
An elevated concentration of fibrinogen in blood is a significant risk factor during many pathological diseases, as it leads to an increase in red blood cells (RBC) aggregation, resulting in hemorheological disorders. Despite the biomedica…
View article: Fluorescence Lifetime and Intensity of Thioflavin T as Reporters of Different Fibrillation Stages: Insights Obtained from Fluorescence Up-Conversion and Particle Size Distribution Measurements
Fluorescence Lifetime and Intensity of Thioflavin T as Reporters of Different Fibrillation Stages: Insights Obtained from Fluorescence Up-Conversion and Particle Size Distribution Measurements Open
Thioflavin T (ThT) assay is extensively used for studying fibrillation kinetics in vitro. However, the differences in the time course of ThT fluorescence intensity and lifetime and other physical parameters of the system, such as particle …
View article: Temperature Dependencies of the Aggregation Properties of RBC in Dextran Solutions In Vitro
Temperature Dependencies of the Aggregation Properties of RBC in Dextran Solutions In Vitro Open
The process of reversible spontaneous aggregation of red blood cells (RBC), as well as the process of their shear stress induced disaggregation, both affect hemorheology and blood microcirculation in the human body. The aim of this work is…
View article: Hyperspectral Holography and Laser Diffractometry of Erythrocytes
Hyperspectral Holography and Laser Diffractometry of Erythrocytes Open
Geometrical 3D models of human red blood cells in dry smear were obtained experimentally using hyperspectral holography technique. Corresponding diffraction patterns in the far field diffraction zone were calculated. Visibility values of t…
View article: Microrheologic properties of blood and capillary blood flow in case of arterial hypertension and type 2 diabetes mellitus: <i>iin vitro</i> and <i>in vivo</i> optical assessment
Microrheologic properties of blood and capillary blood flow in case of arterial hypertension and type 2 diabetes mellitus: <i>iin vitro</i> and <i>in vivo</i> optical assessment Open
Aim . To study microrheological properties of RBCs and capillary blood flow parameters using optical methods in patients with arterial hypertension (AH) and type 2 diabetes mellitus (DM2). Methods . RBCs aggregation properties were evaluat…
View article: Study by optical techniques of the dependence of aggregation parameters of human red blood cells on their deformability
Study by optical techniques of the dependence of aggregation parameters of human red blood cells on their deformability Open
Blood microcirculation in human body is greatly dependent on the microrheologic properties of red blood cells. The aim of this work is to identify the relationship between the deformability of these cells and their aggregation properties, …
View article: The Oxidation-Induced Autofluorescence Hypothesis: Red Edge Excitation and Implications for Metabolic Imaging
The Oxidation-Induced Autofluorescence Hypothesis: Red Edge Excitation and Implications for Metabolic Imaging Open
Endogenous autofluorescence of biological tissues is an important source of information for biomedical diagnostics. Despite the molecular complexity of biological tissues, the list of commonly known fluorophores is strictly limited. Still,…