Alexander W. Blocker
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View article: Decision letter: A statistical framework for assessing pharmacological responses and biomarkers using uncertainty estimates
Decision letter: A statistical framework for assessing pharmacological responses and biomarkers using uncertainty estimates Open
View article: Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA
Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA Open
View article: Quantifying neurologic disease using biosensor measurements in-clinic and in free-living settings in multiple sclerosis
Quantifying neurologic disease using biosensor measurements in-clinic and in free-living settings in multiple sclerosis Open
Technological advances in passive digital phenotyping present the opportunity to quantify neurological diseases using new approaches that may complement clinical assessments. Here, we studied multiple sclerosis (MS) as a model neurological…
View article: High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants
High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants Open
View article: Ultra-deep next-generation sequencing of plasma cell-free DNA in patients with advanced lung cancers: results from the Actionable Genome Consortium
Ultra-deep next-generation sequencing of plasma cell-free DNA in patients with advanced lung cancers: results from the Actionable Genome Consortium Open
View article: A computational approach to map nucleosome positions and alternative chromatin states with base pair resolution
A computational approach to map nucleosome positions and alternative chromatin states with base pair resolution Open
Understanding chromatin function requires knowing the precise location of nucleosomes. MNase-seq methods have been widely applied to characterize nucleosome organization in vivo, but generally lack the accuracy to determine the precise nuc…
View article: Author response: A computational approach to map nucleosome positions and alternative chromatin states with base pair resolution
Author response: A computational approach to map nucleosome positions and alternative chromatin states with base pair resolution Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Understanding chromatin funct…
View article: Template-Based Models for Genome-Wide Analysis of Next-Generation Sequencing Data at Base-Pair Resolution
Template-Based Models for Genome-Wide Analysis of Next-Generation Sequencing Data at Base-Pair Resolution Open
We consider the problem of estimating the genome-wide distribution of nucleosome positions from paired-end sequencing data. We develop a modeling approach based on nonparametric templates to control for the variability along the sequence o…
View article: Template-based models for genome-wide analysis of next-generation sequencing data at base-pair resolution
Template-based models for genome-wide analysis of next-generation sequencing data at base-pair resolution Open
We consider the problem of estimating the genome-wide distribution of nucleosome positions from paired-end sequencing data. We develop a modeling approach based on nonparametric templates to control for the variability along the sequence o…
View article: Two pages (scan) from Galilei's <i>Sidereus Nuncius</i> (“The Starry Messenger” or “The Herald of the Stars”), Venice, 1610.
Two pages (scan) from Galilei's <i>Sidereus Nuncius</i> (“The Starry Messenger” or “The Herald of the Stars”), Venice, 1610. Open
On these pages, Galilei combines data (drawings of Jupiter and its moons), key metadata (timing of each observation, weather, and telescope properties), and text (descriptions of methods, analysis, and conclusions).