Alexander Wentzel
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View article: Application of vibrational spectroscopies as process analytical techniques for monitoring fermentation and the conversion of lignocellulosic biomass by oleaginous filamentous fungi
Application of vibrational spectroscopies as process analytical techniques for monitoring fermentation and the conversion of lignocellulosic biomass by oleaginous filamentous fungi Open
Background Oleaginous filamentous fungi, such as Mucor circinelloides , are capable of accumulating high levels of single cell oil (SCO), making them attractive candidates for the production of biodiesel and other oleochemicals. Lignocellu…
View article: Discovery of MBL-AB01: a novel antibacterial xanthone antibiotic with high activity against methicillin-resistant <i>Staphylococcus aureus</i>
Discovery of MBL-AB01: a novel antibacterial xanthone antibiotic with high activity against methicillin-resistant <i>Staphylococcus aureus</i> Open
A novel compound denoted MBL-AB01 was isolated from a marine Actinoalloteichus , which belongs to a rare and underexplored class of Actinobacteria . This work demonstrates that the novel compound MBL-AB01 shows very high activity in vitro …
View article: Reprogramming <i>Yarrowia lipolytica</i> metabolism for efficient synthesis of itaconic acid from flask to semipilot scale
Reprogramming <i>Yarrowia lipolytica</i> metabolism for efficient synthesis of itaconic acid from flask to semipilot scale Open
Itaconic acid is an emerging platform chemical with extensive applications. Itaconic acid is currently produced by Aspergillus terreus through biological fermentation. However, A. terreus is a fungal pathogen that needs additional morpholo…
View article: Effect of model methanogens on the electrochemical activity, stability, and microbial community structure of Geobacter spp. dominated biofilm anodes
Effect of model methanogens on the electrochemical activity, stability, and microbial community structure of Geobacter spp. dominated biofilm anodes Open
Combining anaerobic digestion (AD) and microbial electrochemical technologies (MET) in AD-MET holds great potential. Methanogens have been identified as one cause of decreased electrochemical activity and deterioration of Geobacter spp. bi…
View article: New dienelactone hydrolase from microalgae bacterial community-Antibiofilm activity against fish pathogens and potential applications for aquaculture
New dienelactone hydrolase from microalgae bacterial community-Antibiofilm activity against fish pathogens and potential applications for aquaculture Open
Biofilms are resistant to many traditional antibiotics, which has led to search for new antimicrobials from different and unique sources. To harness the potential of aquatic microbial resources, we analyzed the meta-omics datasets of micro…
View article: Reprogramming<i>Yarrowia lipolytica</i>metabolism for efficient synthesis of itaconic acid from flask to semi-pilot scale
Reprogramming<i>Yarrowia lipolytica</i>metabolism for efficient synthesis of itaconic acid from flask to semi-pilot scale Open
Itaconic acid is an emerging platform chemical with extensive applications. It is currently produced by Aspergillus terreus through biological fermentation. However, A. terreus is a fungal pathogen and needs additional morphology controls,…
View article: A unified and simple medium for growing model methanogens
A unified and simple medium for growing model methanogens Open
Apart from their archetypic use in anaerobic digestion (AD) methanogenic archaea are targeted for a wide range of applications. Using different methanogenic archaea for one specific application requires the optimization of culture media to…
View article: Health benefits of microalgae and their microbiomes
Health benefits of microalgae and their microbiomes Open
Summary Microalgae comprise a phylogenetically very diverse group of photosynthetic unicellular pro‐ and eukaryotic organisms growing in marine and other aquatic environments. While they are well explored for the generation of biofuels, th…
View article: Increased Butyrate Production in Clostridium saccharoperbutylacetonicum from Lignocellulose-Derived Sugars
Increased Butyrate Production in Clostridium saccharoperbutylacetonicum from Lignocellulose-Derived Sugars Open
Platform chemicals such as butyrate are usually produced chemically from crude oil, resulting in the carry-over of harmful compounds. The selective production of butyrate using sustainable resources or waste without harmful by-products can…
View article: Effect of Elevated Hydrogen Partial Pressure on Mixed Culture Homoacetogenesis
Effect of Elevated Hydrogen Partial Pressure on Mixed Culture Homoacetogenesis Open
This study aimed to systematically investigate the effect of elevated hydrogen partial pressure on mixed culture homoacetogenesis in the range of 1–25 bar. Seven batch experiments were performed at different initial headspace pressures, i.…
View article: Streptomyces tardus sp. nov.: A Slow-Growing Actinobacterium Producing Candicidin, Isolated From Sediments of the Trondheim Fjord
Streptomyces tardus sp. nov.: A Slow-Growing Actinobacterium Producing Candicidin, Isolated From Sediments of the Trondheim Fjord Open
Marine environments are home to an extensive number of microorganisms, many of which remain unexplored for taxonomic novelty and functional capabilities. In this study, a slow-growing Streptomyces strain expressing unique genomic and pheno…
View article: Additional file of Automatic reconstruction of metabolic pathways from identified biosynthetic gene clusters
Additional file of Automatic reconstruction of metabolic pathways from identified biosynthetic gene clusters Open
Additional file of Automatic reconstruction of metabolic pathways from identified biosynthetic gene clusters
View article: Additional file 1 of Automatic reconstruction of metabolic pathways from identified biosynthetic gene clusters
Additional file 1 of Automatic reconstruction of metabolic pathways from identified biosynthetic gene clusters Open
Additional file 1. Details on tailoring reactions and synthesis of the rare extender unit methoxymalonyl-ACP, as well as a description of the analysis used to develop the heuristics that indicate the presence of these reactions from smCOG …
View article: Additional file 2 of Automatic reconstruction of metabolic pathways from identified biosynthetic gene clusters
Additional file 2 of Automatic reconstruction of metabolic pathways from identified biosynthetic gene clusters Open
Additional file 2. Detailed comparison of 8 BGCs for evaluation the accuracy of the BiGMeC pipeline.
View article: Automatic reconstruction of metabolic pathways from identified biosynthetic gene clusters
Automatic reconstruction of metabolic pathways from identified biosynthetic gene clusters Open
Background A wide range of bioactive compounds are produced by enzymes and enzymatic complexes encoded in biosynthetic gene clusters (BGCs). These BGCs can be identified and functionally annotated based on their DNA sequence. Candidates fo…
View article: Microbial-induced calcium carbonate precipitation: An experimental toolbox for in situ and real-time investigation of micro-scale pH evolution
Microbial-induced calcium carbonate precipitation: An experimental toolbox for in situ and real-time investigation of micro-scale pH evolution Open
Concrete is the second most consumed product by humans, after water. However, the production of cement, which is used as a binding material in concrete, causes more than 5% of anthropogenic CO 2 emissions and has therefore a significant co…
View article: Butanol Production from Lignocellulosic Sugars by Clostridium beijerinckii in Microbioreactors
Butanol Production from Lignocellulosic Sugars by Clostridium beijerinckii in Microbioreactors Open
Background: Butanol ( n- butanol) has been gaining attention as a renewable energy carrier and an alternative biofuel with superior properties to the most widely used ethanol. We performed 48 anaerobic fermentations simultaneously with glu…
View article: Microbial-induced calcium carbonate precipitation: an experimental toolbox for <i>in situ</i> and real time investigation of micro-scale pH evolution
Microbial-induced calcium carbonate precipitation: an experimental toolbox for <i>in situ</i> and real time investigation of micro-scale pH evolution Open
We present two novel experimental methods to follow global and local pH changes on a microscale in bio-cementation processes.
View article: Enzyme-constrained models and omics analysis of Streptomyces coelicolor reveal metabolic changes that enhance heterologous production
Enzyme-constrained models and omics analysis of Streptomyces coelicolor reveal metabolic changes that enhance heterologous production Open
Many biosynthetic gene clusters (BGCs) require heterologous expression to realize their genetic potential, including silent and metagenomic BGCs. Although the engineered Streptomyces coelicolor M1152 is a widely used host for heterologous …