Explanipedia

Placental and cord blood DNA methylation in preterm birth: exploring the epigenetic role of maternal dietary protein Open

Fatima Ahmad, Arun Prasath Lakshmanan, Shaikha Alabduljabbar, Salma Ahmed, ASM Nawshad Uddin Ahmed , et al. · 2025

Placental and Cord Blood DNA Methylation Changes Associated With Gestational Diabetes Mellitus in a Marginalized Population: The Untold Role of Saturated Fats Open

Fatima Ahmad, Sidra Aftab Uzair, Arun Prasath Lakshmanan, Shaikha Alabduljabbar, Salma H. Ahmed , et al. · 2025

The role of DNA methylation (DNAm) and its modulation by dietary factors in gestational diabetes mellitus (GDM) remains underexplored, particularly in marginalized populations. This study investigates DNAm alterations in GDM‐exposed cord b…

Exploring the composition of placental microbiome and its potential origin in preterm birth Open

Marwa Saadaoui, Mohamed Nadhir Djekidel, Selvasankar Murugesan, Manoj Kumar, Duaa Ahmed Elhag , et al. · 2025

Introduction For years, the placenta was believed to be sterile, but recent studies reveal it hosts a unique microbiome. Despite these findings, significant questions remain about the origins of the placental microbiome and its effects on …

Design of a targeted blood transcriptional panel for monitoring immunological changes accompanying pregnancy Open

Tobias Brummaier, Darawan Rinchai, Mohammed Toufiq, Mohammed Yousuf Karim, Tanwir Habib , et al. · 2024

Background Immunomodulatory processes exert steering functions throughout pregnancy. Detecting diversions from this physiologic immune clock may help identify pregnant women at risk for pregnancy-associated complications. We present result…

Vaginal Microbiota and Cytokine Levels Predict Preterm Delivery in Asian Women Open

Manoj Kumar, Selvasankar Murugesan, Parul Singh, Marwa Saadaoui, Duaa Ahmed Elhag , et al. · 2021

Preterm birth (PTB) is the most common cause of neonatal morbidity and mortality worldwide. Approximately half of PTBs is linked with microbial etiologies, including pathologic changes to the vaginal microbiota, which vary according to eth…

A Neutrophil-Driven Inflammatory Signature Characterizes the Blood Transcriptome Fingerprint of Psoriasis Open

Arun Rawat, Darawan Rinchai, Mohammed Toufiq, Alexandra K. Marr, Tomoshige Kino , et al. · 2020

Transcriptome profiling approaches have been widely used to investigate the mechanisms underlying psoriasis pathogenesis. Most researchers have measured changes in transcript abundance in skin biopsies; relatively few have examined transcr…

Cohort profile: molecular signature in pregnancy (MSP): longitudinal high-frequency sampling to characterise cross-omic trajectories in pregnancy in a resource-constrained setting Open

Tobias Brummaier, Basirudeen Syed Ahamed Kabeer, Pornpimon Wilaisrisak, Mupawjay Pimanpanarak, Aye Kyi Win , et al. · 2020

Purpose A successful pregnancy relies on the interplay of various biological systems. Deviations from the norm within a system or intersystemic interactions may result in pregnancy-associated complications and adverse pregnancy outcomes. S…

Vaginal microbiota and cytokine levels predict preterm delivery in Asian women Open

Manoj Kumar, Selvasankar Murugesan, Parul Singh, Marwa Saadaoui, Duaa Ahmed Elhag , et al. · 2020

Background: Preterm birth (PTB) is the most common cause of neonatal morbidity and mortality worldwide. Approximately half of PTBs are linked with microbial etiologies, including pathologic changes to the vaginal microbiota, which vary acc…

In silico analysis of imprinted gene expression in the mouse skin Open

Alexandra K. Marr, Sabri Boughorbel, Mohammed Toufiq, Mohammed El Anbari, Aouatef Ismail Chouchane , et al. · 2020

1. Abstract Imprinted genes help mediate embryonic cell proliferation and differentiation, but their roles after birth are far less well understood. A subset of 16 imprinted gene network (IGN) genes is expressed at higher levels in stem ce…

MON-718 Abundant Circulation of Functional Short Non-Coding RNAs Expressed from the Intergenic Area in Mouse Serum Open

Tanwir Habib, Abeer Fadda, Rafah Mackeh, Alexandra K. Marr, Tomoshige Kino · 2020

The human genome expresses numerous and different forms of non-protein-coding (nc) RNAs from over 80% of its sequence in addition to mRNAs. Although their overall functions and biological importance are still under intensive investigation,…

A neutrophil-driven inflammatory signature characterizes the blood cell transcriptome fingerprints of Psoriasis and Kawasaki Disease Open

Arun Rawat, Darawan Rinchai, Mohammed Toufiq, Alexandra K. Marr, Tomoshige Kino , et al. · 2020

Background Transcriptome profiling approaches have been widely used in the investigation of mechanisms underlying psoriasis pathogenesis. In most instances, changes in transcript abundance have been measured in skin biopsies. Fewer studies…

A prospective cohort for the investigation of alteration in temporal transcriptional and microbiome trajectories preceding preterm birth: a study protocol Open

Tobias Brummaier, Basirudeen Syed Ahamed Kabeer, Stephen W. Lindow, Justin C. Konje, Sasithon Pukrittayaamee , et al. · 2019

Introduction Preterm birth (PTB) results from heterogeneous influences and is a major contributor to neonatal mortality and morbidity that continues to have adverse effects on infants beyond the neonatal period. This protocol describes the…

C2H2-Type Zinc Finger Proteins: Evolutionarily Old and New Partners of the Nuclear Hormone Receptors Open

Rafah Mackeh, Alexandra K. Marr, Abeer Fadda, Tomoshige Kino · 2018

Nuclear hormone receptors (NRs) are evolutionarily conserved ligand-dependent transcription factors. They are essential for human life, mediating the actions of lipophilic molecules, such as steroid hormones and metabolites of fatty acid, …

Single-Nucleotide Variations of the Human Nuclear Hormone Receptor Genes in 60,000 Individuals Open

Rafah Mackeh, Alexandra K. Marr, Soha R. Dargham, Najeeb Syed, Khalid A. Fakhro , et al. · 2017

Nuclear hormone receptors (NRs) mediate biologic actions of lipophilic molecules to gene transcription and are phylogenetically and functionally categorized into seven subfamilies and three groups, respectively. Single-nucleotide variation…

A lovely leap toward the development of breast cancer therapy with long non-coding RNAs Open

Tomoshige Kino, Alexandra K. Marr · 2016

Breast cancer is among the most popular malignancies by affecting over 10% of women in Western countries (1). It is a highly heterogeneous cancer with various clinical and pathological phenotypes. Due to its popularity and significant thre…

A curated transcriptome dataset collection to investigate the development and differentiation of the human placenta and its associated pathologies Open

Alexandra K. Marr, Sabri Boughorbel, Scott Presnell, Charlie Quinn, Damien Chaussabel , et al. · 2016

Compendia of large-scale datasets made available in public repositories provide a precious opportunity to discover new biomedical phenomena and to fill gaps in our current knowledge. In order to foster novel insights it is necessary to ens…

A curated transcriptome dataset collection to investigate the development and differentiation of the human placenta and its associated pathologies Open

Alexandra K. Marr, Sabri Boughorbel, Scott Presnell, Charlie Quinn, Damien Chaussabel , et al. · 2016

Compendia of large-scale datasets made available in public repositories provide a precious opportunity to discover new biomedical phenomena and to fill gaps in our current knowledge. In order to foster novel insights it is necessary to ens…

Dataset annotation guide for the Gene Expression Browser (GXB) Open

Alexandra K. Marr, Jana Blažková, Mahbuba Rahman, David Furman, Nico Marr , et al. · 2016

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