Alexandra Chovsepian
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View article: Recanalization and reperfusion in clinically-relevant porcine model of stroke
Recanalization and reperfusion in clinically-relevant porcine model of stroke Open
Introduction Stroke is a leading cause of death and long-term disability. Pigs have been considered an ideal large animal model in biomedicine; however, the complex vascular anatomy has posed challenges for stroke research. Nonetheless, we…
View article: Diabetes increases mortality in patients with pancreatic and colorectal cancer by promoting cachexia and its associated inflammatory status
Diabetes increases mortality in patients with pancreatic and colorectal cancer by promoting cachexia and its associated inflammatory status Open
We show for the first time that pre-existing diabetes aggravates cachexia development in patients with colorectal and pancreatic cancer. This is important when considering cachexia biomarkers and weight management in patients with co-exist…
View article: Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein
Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein Open
View article: Plasticity of callosal neurons in the contralesional cortex following traumatic brain injury
Plasticity of callosal neurons in the contralesional cortex following traumatic brain injury Open
Traumatic brain injury (TBI) represents a significant cause of disability worldwide. It creates a vast array of damaging macro- and microscopic changes in the affected brain area(s), ranging from neuronal cell death, changes in structural …
View article: Selective plasticity of callosal neurons in the adult contralesional cortex following murine traumatic brain injury
Selective plasticity of callosal neurons in the adult contralesional cortex following murine traumatic brain injury Open
View article: Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein
Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein Open
Parkinson′s disease (PD) pathology progresses throughout the nervous system affecting numerous neuronal structures. It has been postulated that the progression of the pathology is based on a prion-like disease mechanism partly due to the s…
View article: A Primeval Mechanism of Tolerance to Desiccation Based on Glycolic Acid Saves Neurons in Mammals from Ischemia by Reducing Intracellular Calcium‐Mediated Excitotoxicity
A Primeval Mechanism of Tolerance to Desiccation Based on Glycolic Acid Saves Neurons in Mammals from Ischemia by Reducing Intracellular Calcium‐Mediated Excitotoxicity Open
Stroke is the second leading cause of death and disability worldwide. Current treatments, such as pharmacological thrombolysis or mechanical thrombectomy, reopen occluded arteries but do not protect against ischemia‐induced damage that occ…
View article: Diffusion kurtosis imaging detects the time‐dependent progress of pathological changes in the oral rotenone mouse model of Parkinson's disease
Diffusion kurtosis imaging detects the time‐dependent progress of pathological changes in the oral rotenone mouse model of Parkinson's disease Open
Clinical diagnosis of Parkinson's disease (PD) occurs typically when a substantial proportion of dopaminergic neurons in the substantia nigra (SN) already died, and the first motor symptoms appear. Therefore, tools enabling the early diagn…
View article: A Primeval Mechanism of Tolerance to Desiccation Based on Glycolic Acid Saves Neurons from Ischemia in Mammals by Reducing Intracellular Calcium-Mediated Excitotoxicity
A Primeval Mechanism of Tolerance to Desiccation Based on Glycolic Acid Saves Neurons from Ischemia in Mammals by Reducing Intracellular Calcium-Mediated Excitotoxicity Open
Stroke is the second leading cause of death and disability worldwide. Current treatments, such as pharmacological thrombolysis or mechanical thrombectomy, re-open occluded arteries but do not protect against ischemia-induced damage that ha…
View article: PET Imaging of the Adenosine A2A Receptor in the Rotenone-Based Mouse Model of Parkinson’s Disease with [18F]FESCH Synthesized by a Simplified Two-Step One-Pot Radiolabeling Strategy
PET Imaging of the Adenosine A2A Receptor in the Rotenone-Based Mouse Model of Parkinson’s Disease with [18F]FESCH Synthesized by a Simplified Two-Step One-Pot Radiolabeling Strategy Open
The adenosine A2A receptor (A2AR) is regarded as a particularly appropriate target for non-dopaminergic treatment of Parkinson’s disease (PD). An increased A2AR availability has been found in the human striatum at early stages of PD and in…
View article: Reappraisal of transcallosal neuron organization in mice and evaluation of their dendritic remodeling and circuit integration following traumatic brain injury
Reappraisal of transcallosal neuron organization in mice and evaluation of their dendritic remodeling and circuit integration following traumatic brain injury Open
Traumatic Brain Injury (TBI) is an enormous global socio-economic burden since, apart from its high death rate, it is the primary cause of coma worldwide and a prevalent cause of long-term disability. Until today there is no established tr…
View article: Heterotopic Transcallosal Projections Are Present throughout the Mouse Cortex
Heterotopic Transcallosal Projections Are Present throughout the Mouse Cortex Open
Transcallosal projection neurons are a population of pyramidal excitatory neurons located in layers II/III and to a lesser extent layer V of the cortex. Their axons form the corpus callosum thereby providing an inter-hemispheric connection…