Alexandra Clément
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View article: Transaortic Flow Rate and Risk Stratification in Moderate Aortic Stenosis
Transaortic Flow Rate and Risk Stratification in Moderate Aortic Stenosis Open
Transaortic FRder < 218 mL/sec is independently associated with adverse outcomes in moderate AS. Further research is needed to determine whether patients with moderate AS and impaired transaortic FR would benefit from more inten…
View article: Mechanical Adaptation of the Right Ventricle to Secondary Tricuspid Regurgitation and Its Association With Patient Outcomes
Mechanical Adaptation of the Right Ventricle to Secondary Tricuspid Regurgitation and Its Association With Patient Outcomes Open
Patients with STR demonstrate significant functional RV remodeling. Patients with severe STR show a significant decrease in RV longitudinal shortening. Apart from STR severity, STR etiology also influences the RV contraction pattern, which…
View article: A novel staging system of cardiac damage in aortic stenosis based on multi-chamber myocardial deformation
A novel staging system of cardiac damage in aortic stenosis based on multi-chamber myocardial deformation Open
Aims This study evaluates whether multi-chamber myocardial deformation analysis using speckle tracking echocardiography (STE) can enhance validated current staging systems and improve risk stratification for patients with moderate-to-sever…
View article: Evaluating Long-Term Outcomes in STEMI Patients with New Left Bundle Branch Block: The Impact of Modifiable Risk Factors
Evaluating Long-Term Outcomes in STEMI Patients with New Left Bundle Branch Block: The Impact of Modifiable Risk Factors Open
Background/Objectives: Coronary artery disease, a leading global cause of death, highlights the essential need for early detection and management of modifiable cardiovascular risk factors to prevent further coronary events. Methods: This s…
View article: Cardiac and Renal Fibrosis, the Silent Killer in the Cardiovascular Continuum: An Up-to-Date
Cardiac and Renal Fibrosis, the Silent Killer in the Cardiovascular Continuum: An Up-to-Date Open
Cardiovascular disease (CVD) and chronic kidney disease (CKD) often coexist and have a major impact on patient prognosis. Organ fibrosis plays a significant role in the pathogenesis of cardio-renal syndrome (CRS), explaining the high incid…
View article: Patient-Related Factors Predicting Stent Thrombosis in Percutaneous Coronary Interventions
Patient-Related Factors Predicting Stent Thrombosis in Percutaneous Coronary Interventions Open
Over the past four decades, percutaneous coronary intervention (PCI) safety and efficacy have significantly improved, particularly with the advent of the drug-eluting stent (DES). First-generation DESs reduced in-stent restenosis rates and…
View article: No difference on angiographic features between women and men in patients with acute coronary syndrome: insights from the ADDICT-ICCU study
No difference on angiographic features between women and men in patients with acute coronary syndrome: insights from the ADDICT-ICCU study Open
Background Previous studies have observed poorer outcomes in women with acute coronary syndrome (ACS). Angiographic features and angioplasty techniques to explain this difference between women and men have rarely been analyzed in recent st…
View article: Multimodality Imaging-Based Therapeutic Decision in Ischemic Cardiomyopathy and Ventricular Tachycardia – a Case Report
Multimodality Imaging-Based Therapeutic Decision in Ischemic Cardiomyopathy and Ventricular Tachycardia – a Case Report Open
Introduction In patients with ischemic heart disease and coronary chronic total occlusion, it is extremely important to assess the presence of myocardial viability via different cardiac imaging techniques in order to predict a potential fu…
View article: Role of Diphosphonates Bone Scintigraphy in Correlation with Biomarkers for a Personalized Approach to ATTR Cardiac Amyloidosis in North-Eastern Romania
Role of Diphosphonates Bone Scintigraphy in Correlation with Biomarkers for a Personalized Approach to ATTR Cardiac Amyloidosis in North-Eastern Romania Open
Transthyretin cardiac amyloidosis (ATTR) is a rare cardiac protein deposition disease characterized by progressive thickening of both ventricles, the inter-atrial-ventricular septum and the atrioventricular valves. The gold standard method…
View article: Interventional Therapy in Refractory Hypertension: An Update
Interventional Therapy in Refractory Hypertension: An Update Open
Hypertension represents a major public health issue, affecting about 26% of the world's population. It is the most common cardiovascular risk factor worldwide, with a prevalence that continues to grow. Among this hypertensive population, a…
View article: Multi-tracer and multiparametric PET imaging to detect the IDH mutation in glioma: a preclinical translational in vitro, in vivo, and ex vivo study
Multi-tracer and multiparametric PET imaging to detect the IDH mutation in glioma: a preclinical translational in vitro, in vivo, and ex vivo study Open
Background This translational study explores multi-tracer PET imaging for the non-invasive detection of the IDH1 mutation which is a positive prognostic factor in glioma. Methods U87 human high-grade glioma (HGG) isogenic cell lines with o…
View article: New Perspectives in the Treatment of Acute and Chronic Heart Failure with Reduced Ejection Fraction
New Perspectives in the Treatment of Acute and Chronic Heart Failure with Reduced Ejection Fraction Open
Acute and chronic heart failure with reduced ejection fraction (HFrEF) is a major public health problem, studies showing a 25% survival rate at 5 years after hospitalization. If left untreated, it is a common and potentially fatal disease.…
View article: Triglyceride-Rich Lipoproteins and Their Remnants as Silent Promoters of Atherosclerotic Cardiovascular Disease and Other Metabolic Disorders: A Review
Triglyceride-Rich Lipoproteins and Their Remnants as Silent Promoters of Atherosclerotic Cardiovascular Disease and Other Metabolic Disorders: A Review Open
While targeting elevated serum levels of low-density lipoprotein cholesterol has been the mainstay of atherosclerosis prevention and treatment for decades, the evidence regarding the atherogenic role of hypertriglyceridemia is still contro…
View article: Consensus and Controversy in the Debate over the Biphasic Impact of Alcohol Consumption on the Cardiovascular System
Consensus and Controversy in the Debate over the Biphasic Impact of Alcohol Consumption on the Cardiovascular System Open
In the past few decades, research has focused on the importance of addressing modifiable risk factors as a means of lowering the risk of cardiovascular disease (CVD), which represents the worldwide leading cause of death. For quite a long …
View article: Multimodality imaging in arrhythmogenic cardiomyopathy
Multimodality imaging in arrhythmogenic cardiomyopathy Open
Arrhythmogenic cardiomyopathy, as it has been recently redefined, is characterized by progressive myocyte loss with fibrosis and fat infiltration of the myocardium, which finally leads to a broad clinical spectrum ranging from heart failur…
View article: Löeffler endocarditis due to idiopathic hypereosinophilic syndrome
Löeffler endocarditis due to idiopathic hypereosinophilic syndrome Open
Hypereosinophilic syndrome encompasses a heterogenous group of non-hematologic and hematologic disorders defined as peripheral blood eosinophilia >1500/mm 3 persisting more than 6 months and eosinophilic end organ complications 1,2 . Löeff…
View article: In vivo characterization of physiological and metabolic changes related to isocitrate dehydrogenase 1 mutation expcression by multiparametric MRI and MRS in a rat model with orthotopically grafted human‐derived glioblastoma cell lines
In vivo characterization of physiological and metabolic changes related to isocitrate dehydrogenase 1 mutation expcression by multiparametric MRI and MRS in a rat model with orthotopically grafted human‐derived glioblastoma cell lines Open
The physiological mechanism induced by the isocitrate dehydrogenase 1 ( IDH1 ) mutation, associated with better treatment response in gliomas, remains unknown. The aim of this preclinical study was to characterize the IDH1 mutation through…
View article: The Importance of Multimodality Imaging in the Diagnosis and Management of Patients with Infiltrative Cardiomyopathies: An Update
The Importance of Multimodality Imaging in the Diagnosis and Management of Patients with Infiltrative Cardiomyopathies: An Update Open
Infiltrative cardiomyopathies (ICMs) comprise a broad spectrum of inherited and acquired conditions (mainly amyloidosis, sarcoidosis, and hemochromatosis), where the progressive buildup of abnormal substances within the myocardium results …
View article: La caractérisation de la mutation IDH1R¹³²H dans un modèle de gliome humain de haut grade par imagerie multimodale, une étude translationnelle in vitro et in vivo
La caractérisation de la mutation IDH1R¹³²H dans un modèle de gliome humain de haut grade par imagerie multimodale, une étude translationnelle in vitro et in vivo Open
The integration of molecular parameters in the classification of gliomas by the WHO in 2016, particularly IDH1R¹³²H mutational status, has significant diagnostic impact. This mutation is associated with a better prognosis but the physiopat…
View article: The Advantages of New Multimodality Imaging in Choosing the Optimal Management Strategy for Patients with Hypertrophic Cardiomyopathy
The Advantages of New Multimodality Imaging in Choosing the Optimal Management Strategy for Patients with Hypertrophic Cardiomyopathy Open
In recent years, significant advances have been made in the diagnosis and therapeutic management of hypertrophic cardiomyopathy (HCM) patients, which has led to an important improvement in their longevity and quality of life. The use of mu…
View article: Left Ventricular Assist Device-Related Complications
Left Ventricular Assist Device-Related Complications Open
Left ventricular assist device (LVAD) has emerged as a safe, durable, and revolutionary therapy for end-stage heart failure patients. Despite the appearance of newer-generation devices that have improved patient outcomes, the burden of adv…
View article: What can hide behind an "idiopathic" dilated cardiomyopathy?
What can hide behind an "idiopathic" dilated cardiomyopathy? Open
Myocarditis is an infectious-inflammatory disease with viral infections being one of the most common infectious cause. When it is superimposed to an individual genetic background, myocarditis may progress into a chronic heart muscle disord…
View article: Trashcano: Developing a quantitative teaching tool to understand ballistics accelerated by explosive volcanic eruptions
Trashcano: Developing a quantitative teaching tool to understand ballistics accelerated by explosive volcanic eruptions Open
Accurate predictions of volcanological phenomena, such as the trajectory of blocks accelerated by volcanic explosions, require quantitative skills training. Large outdoor experiments can be useful to convey concepts of volcanic processes t…
View article: A 1-week extension of a ketogenic diet provides a further decrease in myocardial 18F-FDG uptake and a high detectability of myocarditis with FDG-PET
A 1-week extension of a ketogenic diet provides a further decrease in myocardial 18F-FDG uptake and a high detectability of myocarditis with FDG-PET Open
One-week extension of a ketogenic diet provides a further decrease in the 18F-FDG uptake of normal myocardium and a high detectability of inflammatory areas.
View article: PET imaging of 68Ga-NODAGA-RGD, as compared with 18F-fluorodeoxyglucose, in experimental rodent models of engrafted glioblastoma
PET imaging of 68Ga-NODAGA-RGD, as compared with 18F-fluorodeoxyglucose, in experimental rodent models of engrafted glioblastoma Open
View article: 9.4 EVOLUTION OF CARDIAC FUNCTION AND METABOLISM DURING AGING IN A MURINE ANIMAL MODEL OF OBESITY
9.4 EVOLUTION OF CARDIAC FUNCTION AND METABOLISM DURING AGING IN A MURINE ANIMAL MODEL OF OBESITY Open
Purpose/Background/Objectives: Obesity is a well-known risk factor of cardiovascular diseases and a potentially modifiable determinant of arterial ageing. The objectives of this experimental study were to assess the effects of a long-term …