Alexandra Gellhaus
YOU?
Author Swipe
View article: ERV3-MLT1 provides cis-regulatory elements for human placental functioning and are commonly dysregulated in human-specific preeclampsia
ERV3-MLT1 provides cis-regulatory elements for human placental functioning and are commonly dysregulated in human-specific preeclampsia Open
Background Owing to their transcription factor binding sites, endogenous retroviruses (ERVs) can act as cis-regulatory-elements (CREs). By invading genomes in waves, ERVs offer a substrate for lineage-specific adaptations but also, when dy…
View article: Maternal body composition and the placental-fetal unit under maternal high-fat feeding partially improve by metformin treatment or lifestyle interventions during pregnancy in a mouse model
Maternal body composition and the placental-fetal unit under maternal high-fat feeding partially improve by metformin treatment or lifestyle interventions during pregnancy in a mouse model Open
Although all tested interventions had beneficial effects on the mother and the placental-fetal unit, NI seems to be most promising. Our findings highlight that preventive strategies for women with obesity should aim for pre-counseling advi…
View article: Retrotransposons are co-opted to activate hematopoietic stem cells and erythropoiesis
Retrotransposons are co-opted to activate hematopoietic stem cells and erythropoiesis Open
Hematopoietic stem cells (HSCs) and erythropoiesis are activated during pregnancy and after bleeding by the derepression of retrotransposons, including endogenous retroviruses and long interspersed nuclear elements. Retrotransposon transcr…
View article: Alteration in sB7-H4 Serum Levels and Placental Biomarker Expression after Therapeutic Plasma Exchange in Early-Onset Preeclampsia Patients
Alteration in sB7-H4 Serum Levels and Placental Biomarker Expression after Therapeutic Plasma Exchange in Early-Onset Preeclampsia Patients Open
Therapeutic plasma exchange (TPE) is a widely used treatment for numerous diseases including pregnancy-related conditions. Our prior study on 20 early-onset preeclampsia patients undergoing TPE revealed a significant extension in pregnancy…
View article: Impact of the Immunomodulatory Factor Soluble B7-H4 in the Progress of Preeclampsia by Inhibiting Essential Functions of Extravillous Trophoblast Cells
Impact of the Immunomodulatory Factor Soluble B7-H4 in the Progress of Preeclampsia by Inhibiting Essential Functions of Extravillous Trophoblast Cells Open
A key aspect of preeclampsia pathophysiology is the reduced invasiveness of trophoblasts and the impairment of spiral artery remodelling. Understanding the causes of altered trophoblast function is critical to understand the development of…
View article: Placental glycosylation senses the anti-angiogenic milieu induced by human sFLT1 during pregnancy
Placental glycosylation senses the anti-angiogenic milieu induced by human sFLT1 during pregnancy Open
Abnormal placental angiogenesis during gestation resulting from high levels of anti-angiogenic factors, soluble fms-like tyrosine kinase-1 (sFLT1) and soluble endoglin, has been implicated in the progression of preeclampsia (PE). This hete…
View article: CCN1-Mediated Signaling in Placental Villous Tissues after SARS-CoV-2 Infection in Term Pregnant Women: Implications for Dysregulated Angiogenesis
CCN1-Mediated Signaling in Placental Villous Tissues after SARS-CoV-2 Infection in Term Pregnant Women: Implications for Dysregulated Angiogenesis Open
The global spread of SARS-CoV-2 has increased infections among pregnant women. This study aimed to explore placental pathology alterations and angiogenic factor levels in term pregnant women after SARS-CoV-2 infection in a retrospective si…
View article: The Importance of Vaccination, Variants and Time Point of SARS-CoV-2 Infection in Pregnancy for Stillbirth and Preterm Birth Risk: An Analysis of the CRONOS Register Study
The Importance of Vaccination, Variants and Time Point of SARS-CoV-2 Infection in Pregnancy for Stillbirth and Preterm Birth Risk: An Analysis of the CRONOS Register Study Open
Background: The risk of preterm birth (PTB) and stillbirth increases after a SARS-CoV-2 infection during gestation. We aimed to estimate the risk depending on gestational age at infection (early <28 + 0 and late ≥28 weeks of gestation, WoG…
View article: Overexpression of Human sFLT1 in the Spongiotrophoblast Is Sufficient to Induce Placental Dysfunction and Fetal Growth Restriction in Transgenic Mice
Overexpression of Human sFLT1 in the Spongiotrophoblast Is Sufficient to Induce Placental Dysfunction and Fetal Growth Restriction in Transgenic Mice Open
Preeclampsia (PE) is characterized by maternal hypertension and placental dysfunction, often leading to fetal growth restriction (FGR). It is associated with an overexpression of the anti-angiogenic sFLT1 protein, which originates from the…
View article: Impact of 2 years of <scp>COVID</scp>‐19 pandemic on preterm birth: Experience from a tertiary center of obstetrics in western Germany
Impact of 2 years of <span>COVID</span>‐19 pandemic on preterm birth: Experience from a tertiary center of obstetrics in western Germany Open
Objective To compare preterm birth rates and reasons before and during the COVID‐19‐pandemic using a monocentric, retrospective study. Methods Univariate analysis identified differences in rates and reasons for preterm birth and neonatal o…
View article: Therapeutic Plasma Exchange in Early-Onset Preeclampsia: A 7-Year Monocentric Experience
Therapeutic Plasma Exchange in Early-Onset Preeclampsia: A 7-Year Monocentric Experience Open
Different therapeutic apheresis techniques have been clinically tested to delay preterm delivery in the case of eoPE (early-onset preeclampsia). Our study evaluated the feasibility of TPE (therapeutic plasma exchange) compared to standard-…
View article: Three-Dimensional Histological Characterization of the Placental Vasculature Using Light Sheet Microscopy
Three-Dimensional Histological Characterization of the Placental Vasculature Using Light Sheet Microscopy Open
The placenta is the first embryonic organ, representing the connection between the embryo and the mother, and is therefore necessary for the embryo’s growth and survival. To meet the ever-growing need for nutrient and gas exchange, the mat…
View article: Guidelines to Analyze Preclinical Studies Using Perinatal Derivatives
Guidelines to Analyze Preclinical Studies Using Perinatal Derivatives Open
The last 18 years have brought an increasing interest in the therapeutic use of perinatal derivatives (PnD). Preclinical studies used to assess the potential of PnD therapy include a broad range of study designs. The COST SPRINT Action (CA…
View article: Growth-Restricted Fetuses and Offspring Reveal Adverse Sex-Specific Metabolic Responses in Preeclamptic Mice Expressing Human sFLT1
Growth-Restricted Fetuses and Offspring Reveal Adverse Sex-Specific Metabolic Responses in Preeclamptic Mice Expressing Human sFLT1 Open
Fetal adaptations to harmful intrauterine environments due to pregnancy disorders such as preeclampsia (PE) can negatively program the offspring’s metabolism, resulting in long-term metabolic changes. PE is characterized by increased circu…
View article: Identification of altered miRNAs and their targets in placenta accreta
Identification of altered miRNAs and their targets in placenta accreta Open
Placenta accreta spectrum (PAS) is one of the major causes of maternal morbidity and mortality worldwide with increasing incidence. PAS refers to a group of pathological conditions ranging from the abnormal attachment of the placenta to th…
View article: The immunological role of B7‐H4 in pregnant women with Sars‐Cov2 infection
The immunological role of B7‐H4 in pregnant women with Sars‐Cov2 infection Open
Problem T‐cells are key players in fighting the coronavirus disease 2019 (COVID‐19). The checkpoint molecule B7‐H4, a member of the B7 family, can inhibit T‐cell activation and proliferation by inhibiting NF‐kb expression. We aimed to eluc…
View article: The Impact of Increased Maternal sFlt-1/PlGF Ratio on Motor Outcome of Preterm Infants
The Impact of Increased Maternal sFlt-1/PlGF Ratio on Motor Outcome of Preterm Infants Open
Background The sFlt-1 (soluble fms-like tyrosine kinase-1)/PlGF (placental growth factor) ratio serves as a clinical biomarker to predict the hypertensive, placenta-derived pregnancy disorder pre-eclampsia which is often associated with pl…
View article: Metformin Prevents Key Mechanisms of Obesity-Related Complications in Visceral White Adipose Tissue of Obese Pregnant Mice
Metformin Prevents Key Mechanisms of Obesity-Related Complications in Visceral White Adipose Tissue of Obese Pregnant Mice Open
With the gaining prevalence of obesity, related risks during pregnancy are rising. Inflammation and oxidative stress are considered key mechanisms arising in white adipose tissue (WAT) sparking obesity-associated complications and diseases…
View article: Guidelines to analyse preclinical studies using perinatal derivatives
Guidelines to analyse preclinical studies using perinatal derivatives Open
The last 18 years have brought an increasing interest in the therapeutic use of perinatal derivatives (PnD). Preclinical studies used to assess the potential of PnD therapy include a broad range of study designs. The COST SPRINT Action (CA…
View article: Soluble PD‐L1 and B7‐H4 serum levels during the course of physiological pregnancy
Soluble PD‐L1 and B7‐H4 serum levels during the course of physiological pregnancy Open
Problem The aim of this study was to evaluate the soluble programmed death‐ligand (sPD‐L1) and soluble B7‐H4 (sB7‐H4) serum concentration levels longitudinal throughout the three trimesters of uncomplicated pregnancies. Method of the study…
View article: Systemic Maternal Human sFLT1 Overexpression Leads to an Impaired Foetal Brain Development of Growth‐Restricted Foetuses upon Experimental Preeclampsia
Systemic Maternal Human sFLT1 Overexpression Leads to an Impaired Foetal Brain Development of Growth‐Restricted Foetuses upon Experimental Preeclampsia Open
The pregnancy disorder preeclampsia (PE) is characterized by maternal hypertension, increased level of circulating antiangiogenic soluble fms‐like tyrosine kinase‐1 (sFLT1), and reduced placental perfusion, leading to foetal growth restric…
View article: Circulating Maternal sFLT1 (Soluble fms-Like Tyrosine Kinase-1) Is Sufficient to Impair Spiral Arterial Remodeling in a Preeclampsia Mouse Model
Circulating Maternal sFLT1 (Soluble fms-Like Tyrosine Kinase-1) Is Sufficient to Impair Spiral Arterial Remodeling in a Preeclampsia Mouse Model Open
One driving factor for developing preeclampsia—a pregnancy disorder, often associated with poor spiral artery (SpA)-remodeling and fetal growth restriction—is the anti-angiogenic sFLT1 (soluble fms-like tyrosine kinase-1), which is found t…
View article: Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors
Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors Open
Circadian rhythm is heritable, and paternal circadian disruption affects offspring health via stress hormones in the seminal fluid.
View article: Abnormal expression of the costimulatory molecule B7‐H4 in placental chorionic villous and decidual basalis tissues of patients with preeclampsia and HELLP syndrome
Abnormal expression of the costimulatory molecule B7‐H4 in placental chorionic villous and decidual basalis tissues of patients with preeclampsia and HELLP syndrome Open
Background B7‐H4, a checkpoint molecule of the B7 family, regulates a broad spectrum such as T‐cell activation, cytokine secretion, tumour progression, and invasion capacities. Our previous data revealed that soluble B7‐H4 (sB7‐H4) blood s…
View article: Perinatal Derivatives: Where Do We Stand? A Roadmap of the Human Placenta and Consensus for Tissue and Cell Nomenclature
Perinatal Derivatives: Where Do We Stand? A Roadmap of the Human Placenta and Consensus for Tissue and Cell Nomenclature Open
Progress in the understanding of the biology of perinatal tissues has contributed to the breakthrough revelation of the therapeutic effects of perinatal derivatives (PnD), namely birth-associated tissues, cells, and secreted factors. The s…
View article: CCN3 Signaling Is Differently Regulated in Placental Diseases Preeclampsia and Abnormally Invasive Placenta
CCN3 Signaling Is Differently Regulated in Placental Diseases Preeclampsia and Abnormally Invasive Placenta Open
CCN3 expression levels are correlated to markers of cell cycle arrest oppositely in PE and AIP by activating the FAK/AKT pathway in AIP or down-regulating in PE. This may be one mechanism to explain the different pathological features of p…
View article: RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models
RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models Open
The RUPP procedure is a well-established model for studying the link between placental ischemia and hypertension in the pregnant rat and has been described in detail previously.( 1) First timed pregnant Sprague-Dawley rats purchased from H…
View article: Afamin predicts gestational diabetes in polycystic ovary syndrome patients preconceptionally
Afamin predicts gestational diabetes in polycystic ovary syndrome patients preconceptionally Open
Background Patients suffering from polycystic ovary syndrome (PCOS) are often insulin resistant and at elevated risk for developing gestational diabetes mellitus (GDM). The aim of this study was to explore afamin, which can be determined p…