Alexandra Gouveia
YOU?
Author Swipe
View article: Impact of Obesity and Ageing on the Expression of Key Mediators of SARS-CoV-2 Infection in Human Adipose Tissue
Impact of Obesity and Ageing on the Expression of Key Mediators of SARS-CoV-2 Infection in Human Adipose Tissue Open
Increased body mass index (BMI) and age are associated with COVID-19 severity. SARS-CoV-2 infection occurs through ACE2 binding, with TMPRSS2, ADAM17, and NRP1 facilitating this process. This study describes how adipose tissue (AT) locatio…
View article: Metformin reverses infertility in a mouse model of endometriosis: unveiling disease pathways and implications for future clinical approaches
Metformin reverses infertility in a mouse model of endometriosis: unveiling disease pathways and implications for future clinical approaches Open
These results indicate that application of metformin can alleviate oxidative stress and mitigate fibrosis in endometriosis lesions in a murine model of endometriosis, which highlights metformin's potential as a pharmacological intervention…
View article: Evidence of Browning and Inflammation Features in Visceral Adipose Tissue of Women with Endometriosis
Evidence of Browning and Inflammation Features in Visceral Adipose Tissue of Women with Endometriosis Open
Our findings support an endometriosis' role as a pro-catabolic state along with local signals of VAT browning and inflammation.
View article: High copper levels induce premature senescence in 3T3-L1 preadipocytes
High copper levels induce premature senescence in 3T3-L1 preadipocytes Open
Copper (Cu) dyshomeostasis has been linked to obesity and related morbidities and also to aging. Cu levels are higher in older or obese individuals, and adipose tissue (AT) Cu levels correlate with body mass index. Aging and obesity induce…
View article: A hint for the obesity paradox and the link between obesity, perirenal adipose tissue and Renal Cell Carcinoma progression
A hint for the obesity paradox and the link between obesity, perirenal adipose tissue and Renal Cell Carcinoma progression Open
Increasing evidence supports a role for local fat depots in cancer outcomes. Despite the robust positive association of obesity with renal cell carcinoma (RCCa) diagnosis, increased adiposity is inversely related to RCCa oncological outcom…
View article: Metformin Prevents Endothelial Dysfunction in Endometriosis through Downregulation of ET-1 and Upregulation of eNOS
Metformin Prevents Endothelial Dysfunction in Endometriosis through Downregulation of ET-1 and Upregulation of eNOS Open
This study aimed to evaluate if the treatment with metformin affects the morphologic structure, endothelial function, angiogenesis, inflammation and oxidation-responsive pathways in the heart of mice with surgically induced endometriosis. …
View article: P-343 Metformin reduces endometrial implants and improves fertility in a mouse model of endometriosis
P-343 Metformin reduces endometrial implants and improves fertility in a mouse model of endometriosis Open
Study question Could endometriosis-associated infertility be mitigated by metformin? Summary answer Metformin treatment restored fertility to control rates in endometriosis-induced mice that present lower fertility. Endometrial implants pr…
View article: Cumulative Effect of Cardiovascular Risk Factors on Regulation of AMPK/SIRT1-PGC-1<i>α</i>-SIRT3 Pathway in the Human Erectile Tissue
Cumulative Effect of Cardiovascular Risk Factors on Regulation of AMPK/SIRT1-PGC-1<i>α</i>-SIRT3 Pathway in the Human Erectile Tissue Open
Cardiovascular disease risk factors (CVDRF), especially diabetes mellitus (DM), disrupt oxidative stress response. This condition underlies endothelial dysfunction, early manifested in men as erectile dysfunction. The current study is aime…
View article: Browning effect of the melanocortins among mice different adipose tissue depots
Browning effect of the melanocortins among mice different adipose tissue depots Open
View article: Energy restriction, exercise and atorvastatin treatment improve endothelial dysfunction and inhibit miRNA-155 in the erectile tissue of the aged rat.
Energy restriction, exercise and atorvastatin treatment improve endothelial dysfunction and inhibit miRNA-155 in the erectile tissue of the aged rat. Open
View article: MicroRNAs in lung cancer
MicroRNAs in lung cancer Open
Lung cancer (LC) is a serious public health problem responsible for the majority of cancer deaths and comorbidities in developed countries. Tobacco smoking is considered the main risk factor for LC; however, only a few smokers will be affe…
View article: Intervention of diabetes mellitus and metabolic risk factors in AMPK-PGC1α-SIRT3 pathway in the human corpus cavernosum
Intervention of diabetes mellitus and metabolic risk factors in AMPK-PGC1α-SIRT3 pathway in the human corpus cavernosum Open
Aim:The aim of our retrospective study was to determine the influence of demographic and clinical characteristics of patients, initial stage of disease and tumor size on symptom period in children with malignant tumors.Introduction: One of…
View article: Age-related expression of TGF beta family receptors in human cumulus oophorus cells
Age-related expression of TGF beta family receptors in human cumulus oophorus cells Open
View article: Erratum to “Resveratrol Attenuates Copper‐Induced Senescence by Improving Cellular Proteostasis”
Erratum to “Resveratrol Attenuates Copper‐Induced Senescence by Improving Cellular Proteostasis” Open
[This corrects the article DOI: 10.1155/2017/3793817.].
View article: Resveratrol Attenuates Copper‐Induced Senescence by Improving Cellular Proteostasis
Resveratrol Attenuates Copper‐Induced Senescence by Improving Cellular Proteostasis Open
Copper sulfate‐induced premature senescence (CuSO 4 ‐SIPS) consistently mimetized molecular mechanisms of replicative senescence, particularly at the endoplasmic reticulum proteostasis level. In fact, disruption of protein homeostasis has …
View article: Akt/Smad3 signaling increases with adiposity and correlates to transforming growth factor b (TGF-b) levels in human adipose tissue
Akt/Smad3 signaling increases with adiposity and correlates to transforming growth factor b (TGF-b) levels in human adipose tissue Open
View article: Expression of TGF-beta in different adipose tissue depots is singularly regulated by a high-fat diet and energy restriction
Expression of TGF-beta in different adipose tissue depots is singularly regulated by a high-fat diet and energy restriction Open
View article: Browning of white adipocytes: melanocortins as essential players
Browning of white adipocytes: melanocortins as essential players Open