Alexandra R. Harris
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View article: Supplementary Table S8 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages
Supplementary Table S8 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages Open
Supplementary Table S8: Adjusted regression model results for BRCA2 sensitivity analysis - BRCA2 only carriers
View article: Supplementary Figure S4 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages
Supplementary Figure S4 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages Open
Supplementary Figure S4: A forest plot showing the adjusted beta coefficients for carrier status and IHC markers.
View article: Supplementary Table S5 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages
Supplementary Table S5 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages Open
Supplementary Table S5: Association of carrier status and IHC markers in a subset of NHSII participants
View article: Data from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages
Data from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages Open
Background:Approximately 5% of patients with breast cancer have a rare pathogenic germline genetic variant that is associated with increased breast cancer risk. Mutations in more than 12 genes have been associated with hereditary breast ca…
View article: Supplementary Table S4 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages
Supplementary Table S4 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages Open
Supplementary Table S4: IHC subset participant and breast tumor characteristics
View article: Supplementary Figure S3 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages
Supplementary Figure S3 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages Open
Supplementary Figure S3: A forest plot showing the adjusted beta coefficient for carrier status and the TLS-related genes CXCL13 and LTB.
View article: Supplementary Table S3 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages
Supplementary Table S3 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages Open
Supplementary Table S3: Adjusted association of carrier status and TLS-related gene expression
View article: Supplementary Table S6 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages
Supplementary Table S6 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages Open
Supplementary Table S6: Participant and breast tumor characteristics for BRCA2 sensitivity analysis
View article: Supplementary Table S1 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages
Supplementary Table S1 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages Open
Supplementary Table S1: Unadjusted regression model results for carrier status association with immune features
View article: Supplementary Figure S2 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages
Supplementary Figure S2 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages Open
Supplementary Figure S2: A forest plot of unadjusted beta coefficients for DSB repair-related carrier status and 87 immune features.
View article: Supplementary Table S2 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages
Supplementary Table S2 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages Open
Supplementary Table S2: Adjusted regression model results for carrier status association with immune features
View article: Supplementary Figure S1 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages
Supplementary Figure S1 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages Open
Supplementary Figure S1: A heatmap of unsupervised clustering results of 87 immune features from the 559 individuals in the main analysis.
View article: Supplementary Figure S5 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages
Supplementary Figure S5 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages Open
Supplementary Figure S5: Forest plots showing the adjusted associations of carrier status and immune features for the BRCA2 sensitivity analyses.
View article: Supplementary Table S7 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages
Supplementary Table S7 from The Breast Tumor Immune Microenvironment of DNA Double-Strand Break Repair Pathogenic Variant Carriers Is Enriched with Tumor-Associated Macrophages Open
Supplementary Table S7: Adjusted regression model results for BRCA2 sensitivity analysis - non-BRCA2 Carriers
View article: Single-cell-guided identification of logic-gated antigen combinations for designing effective and safe CAR therapy
Single-cell-guided identification of logic-gated antigen combinations for designing effective and safe CAR therapy Open
Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of hematological malignancies. However, its application in solid tumors remains limited because single targets are unlikely to suffice due to tumor antigen het…
View article: Neighborhood Environment, DNA Methylation, and Presence of Crown-Like Structures of the Breast
Neighborhood Environment, DNA Methylation, and Presence of Crown-Like Structures of the Breast Open
Importance Inflammation impacts cancer risk and tumor biological processes, yet studies linking it to social and environmental risk factors are lacking. Objective To investigate the association of neighborhood deprivation and air pollution…
View article: Association of early menarche with breast tumor molecular features and recurrence
Association of early menarche with breast tumor molecular features and recurrence Open
Background Early menarche is an established risk factor for breast cancer but its molecular contribution to tumor biology and prognosis remains unclear. Methods We profiled transcriptome-wide gene expression in breast tumors (N = 846) and …
View article: FIGURE 1 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
FIGURE 1 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Mutational profiles in breast tumors according to ancestral background of the patients. A, Circos admixture plot showing proportions of West African, European, and Asian ancestry (outer circle) in self-identified AA (blue, inner cir…
View article: Supplementary Table 3 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Supplementary Table 3 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Differentially expressed genes and pathway enrichment analysis comparing the 3 patient groups, EA, AA and Kenyan.
View article: Supplementary Figure 2 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Supplementary Figure 2 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Supplementary Figure 2 shows the distribution of immune cell types in breast tumors.
View article: FIGURE 2 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
FIGURE 2 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Pattern of somatic mutations among AA and EA patients. A, Genes enriched with somatic mutations showing robust frequency differences or exclusivity in AA and EA patients with breast cancer. FOXA1 mutation frequency is shown a…
View article: Supplementary Table 2 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Supplementary Table 2 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Patient characteristics for Kenyan Cohort
View article: Data from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Data from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Women of African descent have the highest breast cancer mortality in the United States and are more likely than women from other population groups to develop an aggressive disease. It remains uncertain to what extent breast cancer in Afric…
View article: Supplementary Table 1 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Supplementary Table 1 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Patient characteristics for NCI-Maryland cohort.
View article: Supplementary Figure 2 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Supplementary Figure 2 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Supplementary Figure 2 shows the distribution of immune cell types in breast tumors.
View article: Supplementary Figure 1 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Supplementary Figure 1 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Supplementary Figure 1 shows the effect of acquired FOXA1 somatic mutations on breast cancer survival.
View article: Supplementary Figure 3 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Supplementary Figure 3 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Supplementary Figure 3 shows mutational signatures in breast tumors and their association with somatic mutations in driver genes and immune cell signatures.
View article: FIGURE 4 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
FIGURE 4 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Neighborhood deprivation and its association with mutational signatures. A, Relationship of the NDI with race/ethnicity, household income, BMI, age, disease stage, tumor ER status, and tumor TP53 and TBX3 mutational st…
View article: Supplementary Figure 4 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Supplementary Figure 4 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Supplementary Figure 4 shows neighborhood deprivation as a determinant of breast cancer survival in the NCI-Maryland cohort.
View article: Supplementary Figure 4 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients
Supplementary Figure 4 from Population-specific Mutation Patterns in Breast Tumors from African American, European American, and Kenyan Patients Open
Supplementary Figure 4 shows neighborhood deprivation as a determinant of breast cancer survival in the NCI-Maryland cohort.