Alexandra J. Poret
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View article: Parallel but distinct adaptive routes in the budding and fission yeasts after 10,000 generations of experimental evolution
Parallel but distinct adaptive routes in the budding and fission yeasts after 10,000 generations of experimental evolution Open
Quantitative genetics approaches designed to understand the evolution of traits have helped improve our understanding of the genetic basis of adaptation. However, they often overlook crucial aspects of adaptation, including the long-term t…
View article: De novo mutations mediate phenotypic switching in an opportunistic human lung pathogen
De novo mutations mediate phenotypic switching in an opportunistic human lung pathogen Open
Bacteria evolving within human hosts encounter selective tradeoffs that render mutations adaptive in one context and deleterious in another. Here, we report that the cystic fibrosis-associated pathogen Burkholderia dolosa overcomes in-huma…
View article: <i>De novo</i>mutations mediate phenotypic switching in an opportunistic human lung pathogen
<i>De novo</i>mutations mediate phenotypic switching in an opportunistic human lung pathogen Open
Bacteria evolving within human hosts encounter selective tradeoffs that render mutations adaptive in one context and deleterious in another. Here, we report that the cystic fibrosis-associated pathogen Burkholderia dolosa overcomes in-huma…
View article: Cutaneous Surgical Wounds Have Distinct Microbiomes from Intact Skin
Cutaneous Surgical Wounds Have Distinct Microbiomes from Intact Skin Open
Commensal bacteria on skin may limit the ability of pathogenic bacteria to cause clinically significant infections. The bacteria on healing acute wounds, which might provide such a protective effect, have not been described using culture-i…
View article: Cutaneous surgical wounds have distinct microbiomes from intact skin
Cutaneous surgical wounds have distinct microbiomes from intact skin Open
Infections are relatively rare following cutaneous surgical procedures, despite the potential for wound exposure to pathogens both during surgery and throughout the healing process. Although gut commensals are believed to reduce the risk o…
View article: Anatomy promotes neutral coexistence of strains in the human skin microbiome
Anatomy promotes neutral coexistence of strains in the human skin microbiome Open
What enables strains of the same species to coexist in a microbiome? Here, we investigate if host anatomy can explain strain co-residence of Cutibacterium acnes , the most abundant species on human skin. We reconstruct on-person evolution …