Alexandra King
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View article: Associations of CD36 rs1761667 with Fat and Umami Food Perception, Diet Quality, and BMI in Two European Studies
Associations of CD36 rs1761667 with Fat and Umami Food Perception, Diet Quality, and BMI in Two European Studies Open
Background/Objectives: Fat, a newly researched taste, has been associated with the cluster of differentiation 36 (CD36) gene, which codes for the CD36 receptor protein. The rs1761667 variant has been associated with fat taste sensitivity. …
View article: TAS1R2 rs35874116 Associations with Taste, Diet, and Health in an Italian Population
TAS1R2 rs35874116 Associations with Taste, Diet, and Health in an Italian Population Open
Background/Objectives: The TAS1R2 SNP rs35874116 has previously been associated with sweet taste, diet, and health status, although never comprehensively in a single study. Also, associations between TAS1R2 and sweet taste might be body ma…
View article: A randomised controlled trial to determine the effect of genotype‐based personalised diet and physical activity advice for <i>FTO</i> genotype (rs9939609) delivered via email on healthy eating motivation in young adults
A randomised controlled trial to determine the effect of genotype‐based personalised diet and physical activity advice for <i>FTO</i> genotype (rs9939609) delivered via email on healthy eating motivation in young adults Open
The prevalence of obesity continues to rise, and public health dietary recommendations are not being adhered to. The transition to higher education is a period of risk for weight gain in young adults and has been demonstrated as a good tim…
View article: Investigating the Role of Genetics in Fatty Acids Oral Perception and Related Traits in Two European Cohorts
Investigating the Role of Genetics in Fatty Acids Oral Perception and Related Traits in Two European Cohorts Open
Unsaturated fatty acids (FAs) can influence various aspects of human biology (e.g., the immune system), and an excess of saturated fatty acids is associated with non-communicable diseases. The orosensory perception of FAs has been demonstr…
View article: Factors influencing the intention of young adults to adopt genotype-based personalised advice on diet and physical activity according to perceived weight status
Factors influencing the intention of young adults to adopt genotype-based personalised advice on diet and physical activity according to perceived weight status Open
Genotype-based dietary and physical activity advice can be delivered to young adults before unhealthy lifestyle behaviours or metabolic and physiological conditions have developed. The aim of the present study was to investigate the factor…
View article: Developing and Deploying a Sepsis Deterioration Machine Learning Algorithm
Developing and Deploying a Sepsis Deterioration Machine Learning Algorithm Open
A sepsis deterioration index is a numerical value predicting the chance of a patient become septic by a predictive model. This model usually has pre-specified input variables that have a high likelihood of predicting the output variable of…
View article: Summary of an environmental scan of HIV and Hepatitis C programs, projects and initiatives in Saskatchewan
Summary of an environmental scan of HIV and Hepatitis C programs, projects and initiatives in Saskatchewan Open
BACKGROUND: In 2019, the human immunodeficiency virus (HIV) and hepatitis C (HCV) diagnosis rates in Saskatchewan (SK) were approximately twice the national rate. To address these high levels, Saskatchewan Stories, a community-based digita…
View article: POS-544 Atrasentan in Patients with Proteinuric Glomerular Diseases (The AFFINITY Study)
POS-544 Atrasentan in Patients with Proteinuric Glomerular Diseases (The AFFINITY Study) Open
Glomerular diseases are a leading cause of morbidity and mortality worldwide and are characterized by proteinuria, a strong predictor of disease progression and end-stage kidney disease. Currently, there are limited therapies and despite t…
View article: Biomedical Machine Maintenance Scheduling
Biomedical Machine Maintenance Scheduling Open
Tissue banks procure approximately 45,000 tissue donations per year, providing nearly 9,000,000 individuals (about half the population of New York) with life-enhancing and life-saving medical procedures. Proper biobank machine maintenance …
View article: Does personalised nutrition advice based on apolipoprotein E and methylenetetrahydrofolate reductase genotype affect dietary behaviour?
Does personalised nutrition advice based on apolipoprotein E and methylenetetrahydrofolate reductase genotype affect dietary behaviour? Open
Background: Dietary intake is linked to numerous modifiable risk factors of cardiovascular disease. Current dietary recommendations in the UK to reduce the risk of cardiovascular disease are not being met. A genotype-based personalised app…
View article: Quantitative Perfusion Measurements in a Novel Large Animal Stroke Model
Quantitative Perfusion Measurements in a Novel Large Animal Stroke Model Open
Stroke is a leading cause of death worldwide [1], and is the third leading cause of death and the leading cause of serious adult disability in New Zealand[2]. The aim of this project was to quantify perfusion changes in the brains of 20 sh…
View article: The Associations Between Bitter and Fat Taste Sensitivity, and Dietary Fat Intake: Are They Impacted by Genetic Predisposition?
The Associations Between Bitter and Fat Taste Sensitivity, and Dietary Fat Intake: Are They Impacted by Genetic Predisposition? Open
A relationship between bitter and fat taste sensitivity, CD36 rs1761667 and TAS2R38 has been demonstrated. However, research is scarce and does not take diet into account. This study aimed to explore associations between genetics, fat and …
View article: Dietary Intake and TCF7L2 rs7903146 T Allele Are Associated with Elevated Blood Glucose Levels in Healthy Individuals
Dietary Intake and TCF7L2 rs7903146 T Allele Are Associated with Elevated Blood Glucose Levels in Healthy Individuals Open
Introduction: Type 2 diabetes (T2D) is a leading cause of global mortality with diet and genetics being considered amongst the most significant risk factors. Recently, studies have identified a single polymorphism of the TCF7L2 gene (rs790…
View article: <i>Notes from the Field</i>: Counterfeit Percocet–Related Overdose Cluster — Georgia, June 2017
<i>Notes from the Field</i>: Counterfeit Percocet–Related Overdose Cluster — Georgia, June 2017 Open
multiagency press conferences on June 6 to notify the public about the presence of the dangerous counterfeit pills.A counterfeit Percocet cluster case was defined as 1) an opioid toxidrome (i.e., with central nervous system depression, res…
View article: Does case management for patients with heart failure based in the community reduce unplanned hospital admissions? A systematic review and meta-analysis
Does case management for patients with heart failure based in the community reduce unplanned hospital admissions? A systematic review and meta-analysis Open
Objectives The aim of this systematic review of randomised controlled trials (RCTs) and controlled trials (non-RCTs, NRCTs) is to investigate the effectiveness and related costs of case management (CM) for patients with heart failure (HF) …