Alexandra L. Bey
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View article: Sleep-Wake States Are Encoded across Emotion Regulation Regions of the Mouse Brain
Sleep-Wake States Are Encoded across Emotion Regulation Regions of the Mouse Brain Open
Emotional dysregulation is highly comorbid with sleep disturbances. Sleep is composed of unique physiological states that are reflected by conserved brain oscillations. Though the role of these state-dependent oscillations in cognitive fun…
View article: Sleep-wake states are encoded across emotion-regulation regions of the mouse brain
Sleep-wake states are encoded across emotion-regulation regions of the mouse brain Open
Emotional dysregulation is highly comorbid with sleep disturbances. Sleep is comprised of unique physiological states that are reflected by conserved brain oscillations. Though the role of these state-dependent oscillations in cognitive fu…
View article: The Role of AtMUS81 in Interference-Insensitive Crossovers in A. thaliana
The Role of AtMUS81 in Interference-Insensitive Crossovers in A. thaliana Open
MUS81 is conserved among plants, animals, and fungi and is known to be involved in mitotic DNA damage repair and meiotic recombination. Here we present a functional characterization of the Arabidopsis thaliana homolog AtMUS81, which has a …
View article: Brain-wide electrical dynamics encode an appetitive socioemotional state
Brain-wide electrical dynamics encode an appetitive socioemotional state Open
Many cortical and subcortical regions contribute to complex social behavior; nevertheless, the network level architecture whereby the brain integrates this information to encode appetitive socioemotional behavior remains unknown. Here we m…
View article: Postnatal inactivation of Shank3 expression is insufficient to produce behavioral phenotypes associated with germline deficiency
Postnatal inactivation of Shank3 expression is insufficient to produce behavioral phenotypes associated with germline deficiency Open
Background: The developmental origins of Autism Spectrum Disorder (ASD) remain largely unknown. To begin to answer this question, a few studies have implemented conditional gene expression technology to induce or rescue ASD-causing mutatio…
View article: Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism
Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism Open
Human neuroimaging studies suggest that aberrant neural connectivity underlies behavioural deficits in autism spectrum disorders (ASDs), but the molecular and neural circuit mechanisms underlying ASDs remain elusive. Here, we describe a co…
View article: Subacute Neuropsychiatric Syndrome in Girls With<i>SHANK3</i>Mutations Responds to Immunomodulation
Subacute Neuropsychiatric Syndrome in Girls With<i>SHANK3</i>Mutations Responds to Immunomodulation Open
Phenotypic and biological characterization of rare monogenic disorders represents 1 of the most important avenues toward understanding the mechanisms of human disease. Among patients with SH3 and multiple ankyrin repeat domains 3 (SHANK3) …
View article: Epigenetic dysregulation of Oxtr in Tet1-deficient mice has implications for neuropsychiatric disorders
Epigenetic dysregulation of Oxtr in Tet1-deficient mice has implications for neuropsychiatric disorders Open
OXTR modulates a variety of behaviors in mammals, including social memory and recognition. Genetic and epigenetic dysregulation of OXTR has been suggested to be implicated in neuropsychiatric disorders, including autism spectrum disorder (…
View article: Environmental enrichment has minimal effects on behavior in the Shank3 complete knockout model of autism spectrum disorder
Environmental enrichment has minimal effects on behavior in the Shank3 complete knockout model of autism spectrum disorder Open
Introduction Several studies have supported the use of enriched environments to prevent the manifestation of ASD‐like phenotypes in laboratory rodents. While the translational value of such experiments is unknown, the findings have been re…
View article: Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers
Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers Open
Genetic defects in the synaptic scaffolding protein gene, SHANK2, are linked to a variety of neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, intellectual disability, and bipolar disorder, but the molecular m…
View article: Using Shank3 Model Mice to Probe the Neuroanatomic Basis of Autism
Using Shank3 Model Mice to Probe the Neuroanatomic Basis of Autism Open
Autism spectrum disorders (ASDs) are increasingly prevalent, and the costs associated with caring for affected patients across the lifespan are immense. However, the pathophysiology and brain regions involved in characteristic behavioral i…
View article: Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism
Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism Open
Human neuroimaging studies suggest that aberrant neural connectivity underlies behavioural deficits in autism spectrum disorders (ASDs), but the molecular and neural circuit mechanisms underlying ASDs remain elusive. Here, we describe a co…